2016
Chapter 14 Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System
Tanowitz H, Wen J, Machado F, Desruisseaux M, Robello C, Garg N. Chapter 14 Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System. 2016, 183-193. DOI: 10.1016/b978-0-12-801078-5.00014-5.ChaptersChagas diseaseThromboxane A2Innate immunityAnti-inflammatory factorsContribution of cytokinesTrypanosoma cruziSignificant morbidityVasoconstrictive actionEndothelin-1Nonendemic areasEndemic areasEicosanoid pathwayCardiovascular systemDiseaseNatural transmissionImmunityOxygen speciesCruziMorbidityChemokinesA2CytokinesPathogenesisLipoxinsMortality
2014
Endothelin-1 and its role in the pathogenesis of infectious diseases
Freeman BD, Machado FS, Tanowitz HB, Desruisseaux MS. Endothelin-1 and its role in the pathogenesis of infectious diseases. Life Sciences 2014, 118: 110-119. PMID: 24780317, PMCID: PMC4538933, DOI: 10.1016/j.lfs.2014.04.021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEndothelin-1Isoforms of endothelinRole of endothelinRickettsia conorii infectionPathogenesis of sepsisPro-inflammatory cytokinesVascular smooth muscle cellsLeukocyte adhesion moleculesSmooth muscle cellsSevere malariaVascular dysfunctionBacterial pneumoniaInflammatory mediatorsVascular tonePotent vasoconstrictorImmunomodulatory propertiesInfectious processAlveolar macrophagesPlatelet aggregationInfectious diseasesMuscle cellsEndothelinAdhesion moleculesPathogenesisChagas disease
2012
Cerebral Malaria We Have Come a Long Way
Shikani HJ, Freeman BD, Lisanti MP, Weiss LM, Tanowitz HB, Desruisseaux MS. Cerebral Malaria We Have Come a Long Way. American Journal Of Pathology 2012, 181: 1484-1492. PMID: 23021981, PMCID: PMC3483536, DOI: 10.1016/j.ajpath.2012.08.010.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCerebral malariaLong-term neurological sequelaeEffective antiparasitic treatmentNeurological sequelaeCerebral damageSerious complicationsPlasmodium infectionAntiparasitic treatmentSignificant burdenMalariaExperimental modelDevastating diseaseSub-Saharan AfricaComplicationsSequelaePathogenesisInfectionAmerican JournalDiseasePathologySurvivorsOriginal research