2018
Trypanosoma cruzi Produces the Specialized Proresolving Mediators Resolvin D1, Resolvin D5, and Resolvin E2
Colas RA, Ashton AW, Mukherjee S, Dalli J, Akide-Ndunge OB, Huang H, Desruisseaux MS, Guan F, Jelicks LA, dos Santos F, Nagajyothi J, Zingman MA, Reyes J, Weiss LM, Serhan CN, Tanowitz HB. Trypanosoma cruzi Produces the Specialized Proresolving Mediators Resolvin D1, Resolvin D5, and Resolvin E2. Infection And Immunity 2018, 86: 10.1128/iai.00688-17. PMID: 29358332, PMCID: PMC5865043, DOI: 10.1128/iai.00688-17.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayResolvin D1Chagas diseaseMediators of inflammationCD-1 miceRvD1 levelsChronic cardiomyopathyAcute myocarditisMyocardial inflammationProinflammatory eicosanoidsProresolving mediatorsChronic phasePathological featuresPlasma levelsLifelong infectionLipid mediatorsResolvin D5Host responseHuman infectionsBacterial infectionsRvD1InflammationInfectionImmunosorbent assayElevated levels
2015
The Brain Microvasculature in Cerebral Malaria
Dorovini-Zis K, Stins M, Desruisseaux M, Martins Y, van der Heyde H. The Brain Microvasculature in Cerebral Malaria. 2015, 68-117. DOI: 10.1201/b19299-4.Peer-Reviewed Original ResearchType of malariaInfection of erythrocytesFemale Anopheles mosquitoesCerebral malariaPeriod of feverGenus PlasmodiumClinical typesMalariaMolecular genetic studiesBrain microvasculatureEarly nineteenth centuryNineteenth centuryHuman bloodAreas of AfricaGenetic studiesPlasmodiumMorbidityFeverInfectionMicrovasculatureBloodMortality
2012
Imaging of Small-Animal Models of Infectious Diseases
Jelicks LA, Lisanti MP, Machado FS, Weiss LM, Tanowitz HB, Desruisseaux MS. Imaging of Small-Animal Models of Infectious Diseases. American Journal Of Pathology 2012, 182: 296-304. PMID: 23201133, PMCID: PMC3969504, DOI: 10.1016/j.ajpath.2012.09.026.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCerebral Malaria We Have Come a Long Way
Shikani HJ, Freeman BD, Lisanti MP, Weiss LM, Tanowitz HB, Desruisseaux MS. Cerebral Malaria We Have Come a Long Way. American Journal Of Pathology 2012, 181: 1484-1492. PMID: 23021981, PMCID: PMC3483536, DOI: 10.1016/j.ajpath.2012.08.010.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCerebral malariaLong-term neurological sequelaeEffective antiparasitic treatmentNeurological sequelaeCerebral damageSerious complicationsPlasmodium infectionAntiparasitic treatmentSignificant burdenMalariaExperimental modelDevastating diseaseSub-Saharan AfricaComplicationsSequelaePathogenesisInfectionAmerican JournalDiseasePathologySurvivorsOriginal researchResponse of Adipose Tissue to Early Infection With Trypanosoma cruzi (Brazil Strain)
Nagajyothi F, Desruisseaux MS, Machado FS, Upadhya R, Zhao D, Schwartz GJ, Teixeira MM, Albanese C, Lisanti MP, Chua SC, Weiss LM, Scherer PE, Tanowitz HB. Response of Adipose Tissue to Early Infection With Trypanosoma cruzi (Brazil Strain). The Journal Of Infectious Diseases 2012, 205: 830-840. PMID: 22293433, PMCID: PMC3274374, DOI: 10.1093/infdis/jir840.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdiponectinAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsChagas DiseaseChemokinesCytokinesI-kappa B KinaseMaleMiceMitogen-Activated Protein KinasesNF-kappa BPPAR gammaReceptors, ChemokineRNA, MessengerSignal TransductionToll-Like Receptor 4Toll-Like Receptor 9Trypanosoma cruziConceptsWhite adipose tissueBrown adipose tissueAdipose tissueCruzi infectionNuclear factor kappa B (NF-κB) levelsToll-like receptor 4Peroxisome proliferator-activated receptor γProliferator-activated receptor γMRNA levelsTrypanosoma cruzi infectionMessenger RNA levelsReceptor 4Adipocyte sizeFat massHigher parasite loadsReceptor γEarly infectionExpression of componentsInfectionB levelsLipid accumulationRNA levelsParasite loadEarly targetProtein kinase pathway