2023
Effects of anti‐tau immunotherapy on reactive microgliosis, cerebral endotheliopathy, and cognitive function in an experimental model of cerebral malaria
Ndunge O, Shikani H, Dai M, Freeman B, Desruisseaux M. Effects of anti‐tau immunotherapy on reactive microgliosis, cerebral endotheliopathy, and cognitive function in an experimental model of cerebral malaria. Journal Of Neurochemistry 2023, 167: 441-460. PMID: 37814468, PMCID: PMC10596299, DOI: 10.1111/jnc.15972.Peer-Reviewed Original ResearchConceptsNeural cell injuryCerebral malariaExperimental CMCell injuryUninfected micePHF-1Cell activationNeurodegenerative diseasesAbnormal regulationExperimental modelAnti-tau immunotherapyTau-targeting therapiesExperimental cerebral malariaGlial cell activationPlasmodium berghei ANKAPlasmodium berghei NK65Abnormal tau phosphorylationSubsequent neurocognitive impairmentSignificant memory impairmentNeural cell damageMicrovascular congestionPbA infectionInflammatory markersBerghei ANKANeurological deficits
2012
Cerebral Malaria We Have Come a Long Way
Shikani HJ, Freeman BD, Lisanti MP, Weiss LM, Tanowitz HB, Desruisseaux MS. Cerebral Malaria We Have Come a Long Way. American Journal Of Pathology 2012, 181: 1484-1492. PMID: 23021981, PMCID: PMC3483536, DOI: 10.1016/j.ajpath.2012.08.010.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCerebral malariaLong-term neurological sequelaeEffective antiparasitic treatmentNeurological sequelaeCerebral damageSerious complicationsPlasmodium infectionAntiparasitic treatmentSignificant burdenMalariaExperimental modelDevastating diseaseSub-Saharan AfricaComplicationsSequelaePathogenesisInfectionAmerican JournalDiseasePathologySurvivorsOriginal research