2021
Ultrafast homomorphic encryption models enable secure outsourcing of genotype imputation
Kim M, Harmanci A, Bossuat J, Carpov S, Cheon J, Chillotti I, Cho W, Froelicher D, Gama N, Georgieva M, Hong S, Hubaux J, Kim D, Lauter K, Ma Y, Ohno-Machado L, Sofia H, Son Y, Song Y, Troncoso-Pastoriza J, Jiang X. Ultrafast homomorphic encryption models enable secure outsourcing of genotype imputation. Cell Systems 2021, 12: 1108-1120.e4. PMID: 34464590, PMCID: PMC9898842, DOI: 10.1016/j.cels.2021.07.010.Peer-Reviewed Original ResearchConceptsHomomorphic encryption techniqueResource-intensive computationsSecure outsourcingGenomic data analysisData securityEncryption modelEncryption techniquePrivacy concernsSource codeMemory requirementsGenetic data analysisData analysisComparable accuracyFundamental stepGenotype imputationImputationDownloadSecurityOutsourcingComputationCodeServicesRequirementsAccuracyMethod
2017
A community effort to protect genomic data sharing, collaboration and outsourcing
Wang S, Jiang X, Tang H, Wang X, Bu D, Carey K, Dyke S, Fox D, Jiang C, Lauter K, Malin B, Sofia H, Telenti A, Wang L, Wang W, Ohno-Machado L. A community effort to protect genomic data sharing, collaboration and outsourcing. Npj Genomic Medicine 2017, 2: 33. PMID: 29263842, PMCID: PMC5677972, DOI: 10.1038/s41525-017-0036-1.Peer-Reviewed Original ResearchGenomic data sharingData sharingSecure computation techniquesPrivacy-preserving techniquesPublic cloud servicesMagnitude performance improvementThird Critical AssessmentData outsourcingCloud servicesPrivacy challengesData privacyHuman genomic dataSecurity researchersPrivacy risksSensitive informationComputer privacyBeacon serviceBiomedical informaticistsSecurity concernsMemory requirementsCollaborative discoveryComputation techniquesComputational runtimePrivacyTrack 2
2013
Genome Sequence Compression with Distributed Source Coding
Wang S, Jiang X, Cui L, Dai W, Deligiannis N, Li P, Xiong H, Cheng S, Ohno-Machado L. Genome Sequence Compression with Distributed Source Coding. 2013, 525-525. DOI: 10.1109/dcc.2013.104.Peer-Reviewed Original ResearchEncoder sideSource codingFile sizeLow processing capabilitiesHigh computational complexityLimited communication bandwidthFile size reductionLow-density parity-check (LDPC) decodersCompression frameworkHash codingBandwidth usageCommunication bandwidthParity-check decoderSequence compressionCompression techniquesAdaptive code lengthComputational complexityProcessing capabilitiesSmall storageMemory requirementsGenome compressionFactor graphGenome dataCode lengthCoding