2024
Chapter 39 Role in reproductive biology and dysfunction in women
Pal L, Taylor H. Chapter 39 Role in reproductive biology and dysfunction in women. 2024, 873-888. DOI: 10.1016/b978-0-323-91386-7.00036-2.Peer-Reviewed Original ResearchVitamin DMaternal vitamin D statusVitamin D inadequacyVitamin D deficiencyVitamin D statusActive hormonal formReproductive physiologyBeneficial roleVitamin D signalingSpectrum of disordersFemale reproductive functionHuman reproductive physiologyD deficiencyD statusDihydroxyvitamin DFemale reproductive physiologyInsulin resistanceCardiovascular diseaseHormonal formMetabolic milieuD signalingReproductive functionPleotropic effectsPathological processesLimited data
2021
Analysis of pleiotropic genetic effects on cognitive decline and systemic inflammation in the Women’s Health Initiative Memory Study
Lutz M, Brown M, Kucgibhatla M, Plassman B, Saldana S, Snively B, Chen J, Henderson V, Manson J, Pal L, Shadyab A, Rapp S, Hayden K. Analysis of pleiotropic genetic effects on cognitive decline and systemic inflammation in the Women’s Health Initiative Memory Study. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.050784.Peer-Reviewed Original ResearchWomen's Health Initiative Memory StudyC-reactive proteinCognitive impairmentSystemic inflammationPlasma lipidsBaseline C-reactive proteinPlasma C-reactive proteinNon-Hispanic white womenAnti-inflammatory mechanismsPlasma lipid levelsGenetic pleiotropyAD risk predictionModerate effect sizeLipid levelsPleiotropic effectsAPOE ε2Immune responseΕ4 alleleTherapeutic approachesCognitive declineCase statusWhite womenLDLPolygenic overlapPathological processes