2023
Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation
Kara F, Tosakulwong N, Lesnick T, Fought A, Schwarz C, Senjem M, Fields J, Min P, Lowe V, Jack C, Bailey K, James T, Lobo R, Manson J, Pal L, Hammers D, Malek‐Ahmadi M, Cedars M, Naftolin F, Miller V, Harman S, Dowling M, Gleason C, Kantarci K. Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.073736.Peer-Reviewed Original ResearchGreater WMH volumeKronos Early Estrogen Prevention StudyHormone therapyPostmenopausal womenWMH volumeHigher SBPBlood pressureHT trialsMenopausal womenGreater white matter hyperintensity volumeWhite matter hyperintensity volumeGood CV healthHigher Blood PressureBlood pressure controlDiastolic blood pressureWhite matter injuryBetter cardiovascular healthAssociation of SBPAntihypertensive usersBaseline SBPPremenopausal womenCV healthHigher systolicCardiovascular healthPrevention StudyHigher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation
Kara F, Tosakulwong N, Lesnick T, Fought A, Schwarz C, Senjem M, Fields J, Min P, Lowe V, Jack C, Bailey K, James T, Lobo R, Manson J, Pal L, Hammers D, Malek‐Ahmadi M, Cedars M, Naftolin F, Miller V, Harman S, Dowling M, Gleason C, Kantarci K. Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.081628.Peer-Reviewed Original ResearchGreater WMH volumeKronos Early Estrogen Prevention StudyHormone therapyPostmenopausal womenWMH volumeHigher SBPBlood pressureHT trialsMenopausal womenGreater white matter hyperintensity volumeWhite matter hyperintensity volumeGood CV healthHigher Blood PressureBlood pressure controlDiastolic blood pressureWhite matter injuryBetter cardiovascular healthAssociation of SBPAntihypertensive usersBaseline SBPPremenopausal womenCV healthHigher systolicCardiovascular healthPrevention StudyCardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial
Kantarci K, Tosakulwong N, Lesnick T, Kara F, Kendall-Thomas J, Kapoor E, Fields J, James T, Lobo R, Manson J, Pal L, Hammers D, Malek-Ahmadi M, Cedars M, Naftolin F, Santoro N, Miller V, Harman S, Dowling N, Gleason C. Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial. Menopause The Journal Of The North American Menopause Society 2023, 31: 10-17. PMID: 37989141, PMCID: PMC10756493, DOI: 10.1097/gme.0000000000002278.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyOral conjugated equine estrogenConjugated equine estrogensBetter cardiovascular healthHormone therapyEquine estrogensInsulin resistanceMenopausal womenCardiovascular healthClinical trialsHormone therapy trialsPerson clinic visitsDiastolic blood pressureHomeostasis model assessmentSelf-reported diabetesYears of onsetMultisite clinical trialLevels of glucoseMicronized progesteroneDiabetes medicationsStudy of participantsCardiometabolic effectsCardiometabolic outcomesClinic visitsBlood pressure
2022
Associations between pituitary-ovarian hormones and cognition in recently menopausal women independent of type of hormone therapy
Kling J, Dowling N, Bimonte-Nelson H, Gleason C, Kantarci K, Stonnington C, Harman S, Naftolin F, Pal L, Cedars M, Manson J, James T, Brinton E, Miller V. Associations between pituitary-ovarian hormones and cognition in recently menopausal women independent of type of hormone therapy. Maturitas 2022, 167: 113-122. PMID: 36395695, PMCID: PMC10077876, DOI: 10.1016/j.maturitas.2022.10.002.Peer-Reviewed Original ResearchConceptsComplex attention tasksLatent growth curve modelsPoor cognitive performancePoorer global cognitionGrowth curve modelsAuditory attentionAttention taskCognitive factorsMental flexibilityVisual attentionExecutive functionCognitive domainsCognitive performanceCognitive trajectoriesGlobal cognitionPituitary-ovarian hormonesHormone therapyBaseline cognitionCognitionHormone levelsNeuropsychological testingMonth 18Menopausal womenEstrone levelsMonth 48