2021
Outcomes of Allogeneic Hematopoietic Cell Transplantation in Patients With Myelofibrosis—A Systematic Review and Meta-Analysis
Bewersdorf JP, Sheth AH, Vetsa S, Grimshaw A, Giri S, Podoltsev NA, Gowda L, Tamari R, Tallman MS, Rampal RK, Zeidan AM, Stahl M. Outcomes of Allogeneic Hematopoietic Cell Transplantation in Patients With Myelofibrosis—A Systematic Review and Meta-Analysis. Transplantation And Cellular Therapy 2021, 27: 873.e1-873.e13. PMID: 34052505, PMCID: PMC8478722, DOI: 10.1016/j.jtct.2021.05.016.Peer-Reviewed Original ResearchConceptsConditioning regimen intensityAllo-HCTRegimen intensityChronic graftTransplant characteristicsGraft failureOverall survivalPatient ageSubgroup analysisDynamic International Prognostic Scoring System scoresSystematic reviewAllogeneic hematopoietic cell transplantationInternational Prognostic Scoring System scoreCurative therapeutic modalityNon-relapse mortalityTransplant-related mortalityMedian patient ageOutcomes of patientsSecondary graft failureCo-primary outcomesHematopoietic cell transplantHematopoietic cell transplantationRandomized clinical trialsHeterogeneity of patientsRandom-effects modelBreaking the Age Barrier: Physicians’ Perceptions of Candidacy for Allogeneic Hematopoietic Cell Transplantation in Older Adults
Mishra A, Preussler JM, Bhatt VR, Bredeson C, Chhabra S, D'Souza A, Dahi PB, Hacker ED, Gowda L, Hashmi SK, Howard DS, Jakubowski A, Jayani R, Koll T, Lin RJ, Olin RL, Popat UR, Rodriguez C, Rosko A, Sabloff M, Sorror ML, Sung AD, Ustun C, Wood WA, Burns L, Artz A. Breaking the Age Barrier: Physicians’ Perceptions of Candidacy for Allogeneic Hematopoietic Cell Transplantation in Older Adults. Transplantation And Cellular Therapy 2021, 27: 617.e1-617.e7. PMID: 33836312, PMCID: PMC8254775, DOI: 10.1016/j.jtct.2021.03.028.Peer-Reviewed Original ResearchConceptsAllogeneic hematopoietic cell transplantationHematopoietic cell transplantationGeriatric assessmentOlder adultsPatient ageCell transplantationHCT physiciansHigh-volume teaching hospitalStandardized geriatric assessmentTransplantation-related morbidityAge 75 yearsSignificant unmet needOnline cross-sectional surveyHealth assessment toolClinical support staffCross-sectional surveyMyeloablative regimenRegimen intensityNonmyeloablative conditioningRisk stratificationTransplant physiciansTeaching hospitalAge 41Most physiciansUnmet need
2020
Allogeneic Hematopoietic Cell Transplantation (allo-HCT) in T-Cell Prolymphocytic Leukemia (T-PLL): An Analysis from the CIBMTR
Murthy H, Ahn K, Estrada-Merly N, Gowda L, Dholaria B, Bal S, Alkhateeb H, Jagadeesh D, Oran B, Nakamura R, Scott B, Sauter C, Foss F, kharfan-Dabaja M, Saber W. Allogeneic Hematopoietic Cell Transplantation (allo-HCT) in T-Cell Prolymphocytic Leukemia (T-PLL): An Analysis from the CIBMTR. Blood 2020, 136: 28-29. DOI: 10.1182/blood-2020-134793.Peer-Reviewed Original ResearchTreatment-related mortalityDisease-free survivalT-cell prolymphocytic leukemiaConditioning intensityLess treatment-related mortalityPoor long-term survivalNon-relapse mortalityPoor performance statusRetrospective multicenter studyHematopoietic cell transplantationOverall survival rateSmall retrospective seriesLimited treatment optionsMarrow Transplant ResearchAnalysis of patientsLong-term survivalRate of survivalAcute GVHDAllo-HCTChronic graftChronic GVHDNMA/Regimen intensityDurable remissionsHost diseaseTransplant Physicians’ Attitudes on Candidacy for Allogeneic Hematopoietic Cell Transplantation (HCT) in Older Patients: The Need for a Standardized Geriatric Assessment (GA) Tool
Mishra A, Preussler J, Al-Mansour Z, Bachanova V, Bhatt V, Bredeson C, Chhabra S, D'Souza A, Dahi P, DeFilipp Z, Gowda L, Hacker E, Hashmi S, Howard D, Jakubowski A, Jayani R, Johnston L, Koll T, Lin R, McCurdy S, Michaelis L, Muffly L, Nathwani N, Olin R, Popat U, Rodriguez C, Rosko A, Runaas L, Sabloff M, Shore T, Shune L, Sorror M, Sung A, Ustun C, Wood W, Burns L, Artz A. Transplant Physicians’ Attitudes on Candidacy for Allogeneic Hematopoietic Cell Transplantation (HCT) in Older Patients: The Need for a Standardized Geriatric Assessment (GA) Tool. Transplantation And Cellular Therapy 2020, 26: s45-s46. DOI: 10.1016/j.bbmt.2019.12.115.Peer-Reviewed Original ResearchHematopoietic cell transplantationKarnofsky performance scoreTransplant physiciansUpper age limitAllogeneic hematopoietic cell transplantationGeriatric assessment toolsNon-myeloablative conditioningMarrow Transplant ResearchOnline cross-sectional surveyHealth assessment toolMajority of centersClinical support staffCross-sectional surveyAssessment toolAdult physiciansMyeloablative regimenOlder ptsRegimen intensityConditioning regimensOlder patientsSupportive careInternational BloodRisk stratificationCell transplantationCurative potential