2024
Metabolic regulation of the mitochondrial immune checkpoint
Montrose D, Saha S, Galluzzi L. Metabolic regulation of the mitochondrial immune checkpoint. OncoImmunology 2024, 13: 2394247. PMID: 39206097, PMCID: PMC11352702, DOI: 10.1080/2162402x.2024.2394247.Peer-Reviewed Original ResearchConceptsTumor-targeting immune responsesColorectal cancer cellsAnticancer immunityImmune checkpointsActivation of cGASMalignant cellsImmune responseCancer cellsDisrupt mitochondrial functionAccumulation of mitochondrial DNACytosolic accumulationMitochondrial dysfunctionMetabolic regulationMitochondrial DNAMitochondrial functionSerine resultsCellsDysfunctionA mitochondrial checkpoint to NF-κB signaling
Guilbaud E, Galluzzi L. A mitochondrial checkpoint to NF-κB signaling. Cell Death & Disease 2024, 15: 477. PMID: 38961079, PMCID: PMC11222492, DOI: 10.1038/s41419-024-06868-3.Peer-Reviewed Original ResearchConceptsDownstream of mitochondrial permeabilizationUbiquitination of mitochondrial proteinsApoptotic caspasesPermeabilized mitochondriaMitochondrial permeabilizationMitochondrial proteinsMitochondrial dysfunctionAutophagic disposalNF-kB activationInflammatory programCaspaseUbiquitinMitochondriaPermeabilizationInflammatory pathwaysProteinPathwayInflammation and mitophagy are mitochondrial checkpoints to aging
Guilbaud E, Sarosiek K, Galluzzi L. Inflammation and mitophagy are mitochondrial checkpoints to aging. Nature Communications 2024, 15: 3375. PMID: 38643254, PMCID: PMC11032393, DOI: 10.1038/s41467-024-47840-1.Peer-Reviewed Original ResearchLive Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids.
Charpentier M, Bloy N, Formenti S, Galluzzi L, Demaria S. Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids. Journal Of Visualized Experiments 2024 PMID: 38647326, DOI: 10.3791/66680.Peer-Reviewed Original ResearchConceptsPatient-derived tumor organoidsClonogenic assayRadiation therapyTumor organoidsCancer cellsIrradiated cancer cellsMeasure of radiosensitivityClinical cancer managementNon-irradiated (controlDose-dependent mannerSingle-cell suspensionsMalignant cellsTumor modelCancer managementCellular radiosensitivitySensitive to irradiationComplex tumor modelsOxidative DNA damageRepair oxidative DNA damageCancer typesDelayed mannerIonizing raysSingle-cell dissociationFlow cytometry-RadiosensitivityTertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer
Kasikova L, Rakova J, Hensler M, Lanickova T, Tomankova J, Pasulka J, Drozenova J, Mojzisova K, Fialova A, Vosahlikova S, Laco J, Ryska A, Dundr P, Kocian R, Brtnicky T, Skapa P, Capkova L, Kovar M, Prochazka J, Praznovec I, Koblizek V, Taskova A, Tanaka H, Lischke R, Mendez F, Vachtenheim J, Heinzelmann-Schwarz V, Jacob F, McNeish I, Halaska M, Rob L, Cibula D, Orsulic S, Galluzzi L, Spisek R, Fucikova J. Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer. Nature Communications 2024, 15: 2528. PMID: 38514660, PMCID: PMC10957872, DOI: 10.1038/s41467-024-46873-w.Peer-Reviewed Original ResearchConceptsHigh-grade serous ovarian carcinomaNon-small cell lung carcinomaTertiary lymphoid structuresCD8+ T cellsT-cell phenotypeTumor mutational burdenT cellsLymphoid structuresB cellsCD8+ T cell compartmentCD8+ T cell phenotypesElevated tumor mutation burdenIntratumoral tertiary lymphoid structuresMature tertiary lymphoid structuresPD1+ T cellsFollicular helper T cellsImmunologically hot tumorB cell profileTumor-infiltrating lymphocytesT cell compartmentAssociated with improved outcomesSerous ovarian carcinomaCell lung carcinomaCohort of patientsHelper T cellsNon-mutational neoantigens in disease
Stern L, Clement C, Galluzzi L, Santambrogio L. Non-mutational neoantigens in disease. Nature Immunology 2024, 25: 29-40. PMID: 38168954, PMCID: PMC11075006, DOI: 10.1038/s41590-023-01664-1.Peer-Reviewed Original ResearchConceptsNon-canonical initiation codonsPost-translational protein modificationMature T cellsRibosomal RNA processingAlternative RNA splicingProtein-coding regionsNon-mutational mechanismsAbility of mammalsRNA processingRNA splicingInitiation codonProtein modificationHuman diseasesMature T cell repertoireAntigenic peptidesImmune recognitionAdaptive immune responsesT cellsAntigenic determinantsMHC class ICellsSplicingNovel antigenic determinantsMammalsCodonAnimal models of disease: Achievements and challenges
Bravo-San Pedro J, Aranda F, Buqué A, Galluzzi L. Animal models of disease: Achievements and challenges. Methods In Cell Biology 2024, 188: xv-xxi. PMID: 38880531, DOI: 10.1016/s0091-679x(24)00164-x.Peer-Reviewed Original ResearchCellular senescence and aging at the crossroad between immunity and cancer
Kepp O, Galluzzi L, Petroni G. Cellular senescence and aging at the crossroad between immunity and cancer. Methods In Cell Biology 2024, 181: xvii-xxiv. PMID: 38302247, DOI: 10.1016/s0091-679x(24)00009-8.Peer-Reviewed Original ResearchEpigenetic regulation of cancer
Spada S, Galluzzi L. Epigenetic regulation of cancer. International Review Of Cytology 2024, 387: xiii-xvii. PMID: 39179351, DOI: 10.1016/s1937-6448(24)00113-8.Peer-Reviewed Original Research
2023
Bacterial antigens unleash tumor-targeting immunity
Boeck N, Trajanoski Z, Galluzzi L. Bacterial antigens unleash tumor-targeting immunity. Cell Host & Microbe 2023, 31: 1945-1947. PMID: 38096784, PMCID: PMC11075005, DOI: 10.1016/j.chom.2023.11.001.Peer-Reviewed Original Research