Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer
Kasikova L, Rakova J, Hensler M, Lanickova T, Tomankova J, Pasulka J, Drozenova J, Mojzisova K, Fialova A, Vosahlikova S, Laco J, Ryska A, Dundr P, Kocian R, Brtnicky T, Skapa P, Capkova L, Kovar M, Prochazka J, Praznovec I, Koblizek V, Taskova A, Tanaka H, Lischke R, Mendez F, Vachtenheim J, Heinzelmann-Schwarz V, Jacob F, McNeish I, Halaska M, Rob L, Cibula D, Orsulic S, Galluzzi L, Spisek R, Fucikova J. Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer. Nature Communications 2024, 15: 2528. PMID: 38514660, PMCID: PMC10957872, DOI: 10.1038/s41467-024-46873-w.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Non-Small-Cell LungCD8-Positive T-LymphocytesFemaleHumansLung NeoplasmsLymphocytes, Tumor-InfiltratingOvarian NeoplasmsPhenotypeTertiary Lymphoid StructuresTumor MicroenvironmentConceptsHigh-grade serous ovarian carcinomaNon-small cell lung carcinomaTertiary lymphoid structuresCD8+ T cellsT-cell phenotypeTumor mutational burdenT cellsLymphoid structuresB cellsCD8+ T cell compartmentCD8+ T cell phenotypesElevated tumor mutation burdenIntratumoral tertiary lymphoid structuresMature tertiary lymphoid structuresPD1+ T cellsFollicular helper T cellsImmunologically hot tumorB cell profileTumor-infiltrating lymphocytesT cell compartmentAssociated with improved outcomesSerous ovarian carcinomaCell lung carcinomaCohort of patientsHelper T cells