Metabolic regulation of the mitochondrial immune checkpoint
Montrose D, Saha S, Galluzzi L. Metabolic regulation of the mitochondrial immune checkpoint. OncoImmunology 2024, 13: 2394247. PMID: 39206097, PMCID: PMC11352702, DOI: 10.1080/2162402x.2024.2394247.Peer-Reviewed Original ResearchConceptsTumor-targeting immune responsesColorectal cancer cellsAnticancer immunityImmune checkpointsActivation of cGASMalignant cellsImmune responseCancer cellsDisrupt mitochondrial functionAccumulation of mitochondrial DNACytosolic accumulationMitochondrial dysfunctionMetabolic regulationMitochondrial DNAMitochondrial functionSerine resultsCellsDysfunction