Novel Pharmacologic Candidates for Treatment of Primary Open-Angle Glaucoma.
Lu LJ, Tsai JC, Liu J. Novel Pharmacologic Candidates for Treatment of Primary Open-Angle Glaucoma. The Yale Journal Of Biology And Medicine 2017, 90: 111-118. PMID: 28356898, PMCID: PMC5369028.Peer-Reviewed Original ResearchMeSH KeywordsGlaucoma, Open-AngleHumansIntraocular PressureIsoquinolinesOxepinsProstaglandins F, SyntheticRho-Associated KinasesSulfonamidesConceptsPrimary open-angle glaucomaOpen-angle glaucomaIntraocular pressureProstaglandin analoguesDrug-related side effectsCurrent medical treatment optionsLowering of IOPTarget intraocular pressureMedical treatment optionsVisual field lossAlpha-adrenergic agonistsNew pharmacologic optionsLower intraocular pressureMultiple daily administrationBeta-adrenergic antagonistsAdenosine receptor agonistsLow patient complianceAqueous humor outflowRho-kinase inhibitorTrabecular meshwork outflow pathwaysLatanoprostene bunodPharmacologic optionsPharmacologic treatmentTopical medicationsDaily administration