2021
The Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States
Katz D, Bateman BT, Kjaer K, Turner DP, Spence NZ, Habib AS, George RB, Toledano RD, Grant G, Madden HE, Butwick AJ, Lynde G, Minehart RD, Beilin Y, Houle TT, Sharpe EE, Kodali B, Bharadwaj S, Farber MK, Palanisamy A, Prabhu M, Gonzales NY, Landau R, Leffert L. The Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States. Anesthesia & Analgesia 2021, 133: 462-473. PMID: 33830956, DOI: 10.1213/ane.0000000000005592.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesia, ObstetricalAnesthesia, GeneralAnesthesia, ObstetricalCase-Control StudiesCesarean SectionCOVID-19Delivery, ObstetricFemaleGestational AgeHumansInfant, PrematurePregnancyPregnancy Complications, InfectiousPremature BirthRegistriesRisk AssessmentRisk FactorsUnited StatesYoung AdultConceptsSARS-CoV-2 patientsSARS-CoV-2 infectionWeeks of gestationCesarean deliveryObstetric anesthesiaPositive SARS-CoV-2 polymerase chain reaction testSARS-CoV-2 polymerase chain reaction testAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSARS-CoV-2-infected patientsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreakSyndrome coronavirus 2 infectionMaternal respiratory failureAdverse pregnancy outcomesCoronavirus 2 infectionNeuraxial labor analgesiaUS cohort studyDays of deliveryUS medical centersPolymerase chain reaction testComposite outcome measureAnalysis of outcomesChain reaction testPeripartum outcomesAsymptomatic patientsThe Society for Obstetric Anesthesia and Perinatology Interdisciplinary Consensus Statement on Neuraxial Procedures in Obstetric Patients With Thrombocytopenia
Bauer ME, Arendt K, Beilin Y, Gernsheimer T, Perez Botero J, James AH, Yaghmour E, Toledano RD, Turrentine M, Houle T, MacEachern M, Madden H, Rajasekhar A, Segal S, Wu C, Cooper JP, Landau R, Leffert L. The Society for Obstetric Anesthesia and Perinatology Interdisciplinary Consensus Statement on Neuraxial Procedures in Obstetric Patients With Thrombocytopenia. Anesthesia & Analgesia 2021, 132: 1531-1544. PMID: 33861047, DOI: 10.1213/ane.0000000000005355.Peer-Reviewed Original ResearchMeSH KeywordsAdvisory CommitteesAnesthesia, ObstetricalConsensusFemaleHumansPerinatologyPregnancySocieties, MedicalThrombocytopeniaConceptsSpinal epidural hematomaObstetric patientsNeuraxial proceduresImmune thrombocytopeniaEpidural hematomaGeneral anesthesiaRisk factorsObstetric risk factorsRisk-benefit discussionsDiagnosis of thrombocytopeniaRelevant professional societiesInterdisciplinary consensus statementGestational thrombocytopeniaThrombocytopenia etiologyHypertensive disordersPatient comorbiditiesCesarean deliveryProfessional societiesAirway examinationPotential morbidityPlatelet countPatient preferencesObstetric anesthesiaAirway equipmentAffected patients
2020
Pragmatic approach to neuraxial anesthesia in obstetric patients with disorders of the vertebral column, spinal cord and neuromuscular system
Walsh E, Zhang Y, Madden H, Lehrich J, Leffert L. Pragmatic approach to neuraxial anesthesia in obstetric patients with disorders of the vertebral column, spinal cord and neuromuscular system. Regional Anesthesia & Pain Medicine 2020, 46: 258-267. PMID: 33115718, DOI: 10.1136/rapm-2020-101792.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesia, ObstetricalAnesthesia, ObstetricalAnesthesia, SpinalCesarean SectionFemaleHumansPregnancyRetrospective StudiesSpinal CordSpineConceptsNeuraxial anesthesiaObstetric patientsSpinal cordCesarean delivery anesthesiaCesarean deliveryLabor analgesiaNeuraxial analgesiaVertebral columnCase seriesGeneral anesthesiaObstetrical patientsRetrospective studyDelivery anesthesiaPatient injuryAnesthesiaPatient harmPatientsNarrative reviewAvailable evidenceUnwarranted fearsNeuromuscular systemAdditional riskPresent unique challengesAnalgesiaCordGloving up for the fight against racial and ethnic disparities in obstetric anesthesia care
Lee A, Leffert L. Gloving up for the fight against racial and ethnic disparities in obstetric anesthesia care. Journal Of Clinical Anesthesia 2020, 67: 109988. PMID: 32711352, DOI: 10.1016/j.jclinane.2020.109988.Peer-Reviewed Original Research
2019
Acute Fatty Liver of Pregnancy: Pathophysiology, Anesthetic Implications, and Obstetrical Management.
Naoum EE, Leffert LR, Chitilian HV, Gray KJ, Bateman BT. Acute Fatty Liver of Pregnancy: Pathophysiology, Anesthetic Implications, and Obstetrical Management. Anesthesiology 2019, 130: 446-461. PMID: 30707120, PMCID: PMC7037575, DOI: 10.1097/aln.0000000000002597.Peer-Reviewed Original ResearchMeSH KeywordsAnesthesia, ObstetricalDelivery, ObstetricDisease ManagementFatty LiverFemaleHumansPregnancyPregnancy Complications
2018
The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants
Leffert L, Butwick A, Carvalho B, Arendt K, Bates SM, Friedman A, Horlocker T, Houle T, Landau R, Dubois H, Fernando R, Houle T, Kopp S, Montgomery D, Pellegrini J, Smiley R, Toledo P. The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants. Anesthesia & Analgesia 2018, 126: 928-944. PMID: 29099429, DOI: 10.1213/ane.0000000000002530.Peer-Reviewed Original ResearchConceptsHigh-dose anticoagulantsConsensus statementMaternal deathsObstetric anesthesiaNeuraxial proceduresPerinatology Consensus StatementPharmacodynamics of anticoagulantsUse of thromboprophylaxisRisk-benefit discussionsKey preventive measuresObstetric populationObstetric surgeryCesarean deliveryNeuraxial analgesiaVenous thromboembolismAnesthetic managementObstetric patientsDifficult airwayNeuraxial anesthesiaGeneral anesthesiaPostpartum womenPregnant womenFetal harmPostpartum periodLeading cause
2017
Neuraxial Anesthesia in Obstetric Patients Receiving Thromboprophylaxis With Unfractionated or Low-Molecular-Weight Heparin
Leffert LR, Dubois HM, Butwick AJ, Carvalho B, Houle TT, Landau R. Neuraxial Anesthesia in Obstetric Patients Receiving Thromboprophylaxis With Unfractionated or Low-Molecular-Weight Heparin. Anesthesia & Analgesia 2017, 125: 223-231. PMID: 28628578, DOI: 10.1213/ane.0000000000002173.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnesthesia, ConductionAnesthesia, ObstetricalAnesthesiologyAnestheticsAnticoagulantsCesarean SectionDelivery, ObstetricFemaleHematoma, Epidural, SpinalHeparinHeparin, Low-Molecular-WeightHumansMiddle AgedNerve BlockPregnancyPregnancy Complications, CardiovascularThrombosisYoung AdultConceptsSpinal epidural hematomaCases of SEHNeuraxial anesthesiaObstetric patientsVenous thromboembolismWeight heparinAnesthesia Closed Claims Project databaseSystematic reviewPractice changePostpartum venous thromboembolismVaginal delivery hospitalizationsWeight heparin doseRisk of thromboembolismLarge-scale registriesMajority of womenEnglish-language studiesAnticoagulated womenDelivery hospitalizationsPharmacological thromboprophylaxisAnticoagulant doseCesarean deliveryEpidural hematomaHeparin doseVaginal deliveryGeneral anesthesia
2016
Integrating the New Thromboprophylaxis Guidelines Into Obstetric Anesthesia Practice
Leffert L, Landau R. Integrating the New Thromboprophylaxis Guidelines Into Obstetric Anesthesia Practice. Anesthesia & Analgesia 2016, 123: 809-811. PMID: 27636568, DOI: 10.1213/ane.0000000000001567.Peer-Reviewed Original Research
2015
What’s New in Obstetric Anesthesia
Leffert L. What’s New in Obstetric Anesthesia. Anesthesia & Analgesia 2015, 120: 1065-1073. PMID: 25811260, DOI: 10.1213/ane.0000000000000686.Peer-Reviewed Original ResearchAnesthesia, ObstetricalDelivery, ObstetricFemaleHumansHypertension, Pregnancy-InducedInfantInfant, NewbornMaternal HealthMaternal Health ServicesMaternal MortalityNeonatologyPerinatal MortalityPerinatologyPostpartum HemorrhagePregnancyPregnancy ComplicationsPregnancy OutcomeRisk AssessmentRisk FactorsWhat’s new in obstetric anesthesia? Focus on preeclampsia
Leffert L. What’s new in obstetric anesthesia? Focus on preeclampsia. International Journal Of Obstetric Anesthesia 2015, 24: 264-271. PMID: 25936785, DOI: 10.1016/j.ijoa.2015.03.008.Peer-Reviewed Original ResearchMeSH KeywordsAnesthesia, ObstetricalComorbidityFemaleHumansHypertensionPractice Guidelines as TopicPre-EclampsiaPregnancyConceptsMulti-organ systemsHigh-risk patientsPrevalence of preeclampsiaDefinition of preeclampsiaObstetric care teamPregnant patientsFetal effectsObstetric anesthesiaClinical managementCare teamPreeclampsiaTherapeutic interventionsPatientsContemporary dataRecent updatesComorbiditiesMorbidityPregnancyAnesthesiaPathogenesisEtiologyFetusesPrevalenceDiagnosisCare
2014
In Reply
Leffert LR, Schwamm LH. In Reply. Anesthesiology 2014, 120: 1278. PMID: 24755789, DOI: 10.1097/aln.0000000000000164.Peer-Reviewed Original ResearchAnesthesia, EpiduralAnesthesia, ObstetricalEncephaloceleHumansIntracranial PressureRisk AssessmentSpinal Puncture
2013
Neuraxial Anesthesia in Parturients with Intracranial Pathology
Leffert LR, Schwamm LH. Neuraxial Anesthesia in Parturients with Intracranial Pathology. Anesthesiology 2013, 119: 703-718. PMID: 23584382, DOI: 10.1097/aln.0b013e31829374c2.Peer-Reviewed Original ResearchEpidemiology of Obstetric-Related ICU Admissions in Maryland
Wanderer JP, Leffert LR, Mhyre JM, Kuklina EV, Callaghan WM, Bateman BT. Epidemiology of Obstetric-Related ICU Admissions in Maryland. Critical Care Medicine 2013, 41: 1844-1852. PMID: 23648568, PMCID: PMC3716838, DOI: 10.1097/ccm.0b013e31828a3e24.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, InducedAdolescentAdultAnesthesia, ObstetricalBlack PeopleCerebrovascular DisordersEmergency Service, HospitalFemaleHeart DiseasesHumansInfectionsIntensive Care UnitsLength of StayLiver FailureMarylandMaternal AgeMedicaidPatient AdmissionPatient TransferPregnancyPregnancy ComplicationsPregnancy, EctopicPuerperal DisordersPulmonary EmbolismRespiratory InsufficiencyUnited StatesWounds and InjuriesYoung AdultConceptsICU admissionPregnancy-related hypertensive diseaseRate of sepsisCritical care managementAppropriate International ClassificationClinical Modification codesTransfer of womenEctopic pregnancyAnesthetic complicationsHypertensive diseaseICU populationICU utilizationPostpartum patientsPulmonary embolismGenitourinary infectionsSevere morbidityCommon diagnosisCerebrovascular diseaseObstetric servicesPostpartum periodPostpartum conditionsCardiac diseaseInternational ClassificationAdmissionCare managementSpinal Anesthesia in Severe Preeclampsia
Henke VG, Bateman BT, Leffert LR. Spinal Anesthesia in Severe Preeclampsia. Anesthesia & Analgesia 2013, 117: 686-693. PMID: 23868886, DOI: 10.1213/ane.0b013e31829eeef5.Peer-Reviewed Original ResearchConceptsSevere preeclampsiaSpinal anesthesiaIntraoperative hemodynamic managementSpinal-induced hypotensionHealthy parturientsAnesthetic optionsCesarean deliveryEpidural catheterHemodynamic managementNeuraxial anesthesiaEpidural anesthesiaHigh incidencePreeclampsiaAnesthesiaHypotensionSignificant differencesParturientsContraindicationsCatheterIncidence
2009
Clinical Implications of Neuraxial Anesthesia in the Parturient with Scoliosis
Ko JY, Leffert LR. Clinical Implications of Neuraxial Anesthesia in the Parturient with Scoliosis. Anesthesia & Analgesia 2009, 109: 1930-1934. PMID: 19923523, DOI: 10.1213/ane.0b013e3181bc3584.Peer-Reviewed Original Research