2021
The Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States
Katz D, Bateman BT, Kjaer K, Turner DP, Spence NZ, Habib AS, George RB, Toledano RD, Grant G, Madden HE, Butwick AJ, Lynde G, Minehart RD, Beilin Y, Houle TT, Sharpe EE, Kodali B, Bharadwaj S, Farber MK, Palanisamy A, Prabhu M, Gonzales NY, Landau R, Leffert L. The Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States. Anesthesia & Analgesia 2021, 133: 462-473. PMID: 33830956, DOI: 10.1213/ane.0000000000005592.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesia, ObstetricalAnesthesia, GeneralAnesthesia, ObstetricalCase-Control StudiesCesarean SectionCOVID-19Delivery, ObstetricFemaleGestational AgeHumansInfant, PrematurePregnancyPregnancy Complications, InfectiousPremature BirthRegistriesRisk AssessmentRisk FactorsUnited StatesYoung AdultConceptsSARS-CoV-2 patientsSARS-CoV-2 infectionWeeks of gestationCesarean deliveryObstetric anesthesiaPositive SARS-CoV-2 polymerase chain reaction testSARS-CoV-2 polymerase chain reaction testAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSARS-CoV-2-infected patientsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreakSyndrome coronavirus 2 infectionMaternal respiratory failureAdverse pregnancy outcomesCoronavirus 2 infectionNeuraxial labor analgesiaUS cohort studyDays of deliveryUS medical centersPolymerase chain reaction testComposite outcome measureAnalysis of outcomesChain reaction testPeripartum outcomesAsymptomatic patients
2019
Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women
Bauer ME, Housey M, Bauer ST, Behrmann S, Chau A, Clancy C, Clark EAS, Einav S, Langen E, Leffert L, Lin S, Madapu M, Maile MD, McQuaid-Hanson E, Priessnitz K, Sela HY, Shah A, Sobolewski P, Toledo P, Tsen LC, Bateman BT. Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women. Anesthesia & Analgesia 2019, Publish Ahead of Print: &na;. PMID: 31743182, PMCID: PMC7543988, DOI: 10.1213/ane.0000000000003709.Peer-Reviewed Original ResearchConceptsSystemic inflammatory response syndromeQuick Sequential Organ Failure AssessmentRisk factorsDelivery hospitalizationsMaternal sepsisSepsis casesCommon causeMortality rateMaternal Early Warning CriteriaSequential Organ Failure AssessmentScreening toolHours of diagnosisTiming of antibioticsOrgan Failure AssessmentCohort of patientsInflammatory response syndromePotential risk factorsHalf of casesAcademic medical centerDate of deliveryQSOFA criteriaControl patientsAntibiotic therapyResponse syndromeSignificant morbidity
2018
The Role of the Anesthesiologist in Preventing Severe Maternal Morbidity and Mortality
McQUAID E, Leffert LR, Bateman BT. The Role of the Anesthesiologist in Preventing Severe Maternal Morbidity and Mortality. Clinical Obstetrics & Gynecology 2018, 61: 372-386. PMID: 29319586, DOI: 10.1097/grf.0000000000000350.Peer-Reviewed Original ResearchMeSH KeywordsAirway ManagementAnesthesia, EpiduralAnesthesia, GeneralAnesthesiologistsAnesthetics, LocalBlood TransfusionEchocardiographyEpidural AbscessFemaleHeadacheHematoma, Epidural, SpinalHumansIntubation, IntratrachealMaternal DeathMeningitisMonitoring, PhysiologicObstetric Labor ComplicationsPhysician's RolePregnancyPuerperal DisordersRespiratory AspirationRisk FactorsConceptsObstetric anesthesiologistSevere maternal morbidityLife-saving interventionsMaternal morbidityCesarean deliveryUnstable patientsGeneral anesthesiaObstetric suiteObstetric proceduresBedside managementClinical scenariosAnesthesiologistsIntensivistsAnesthesiaGreater experienceDeliveryAnalgesiaMorbidityPatientsUnique roleMortalityCliniciansRegional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy
Horlocker TT, Vandermeuelen E, Kopp SL, Gogarten W, Leffert LR, Benzon HT. Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy. Regional Anesthesia & Pain Medicine 2018, 43: 263-309. PMID: 29561531, DOI: 10.1097/aap.0000000000000763.Peer-Reviewed Original Research
2017
Canadian stroke best practice consensus statement: Secondary stroke prevention during pregnancy
Swartz RH, Ladhani NNN, Foley N, Nerenberg K, Bal S, Barrett J, Bushnell C, Chan WS, Chari R, Dowlatshahi D, Amrani ME, Gandhi S, Gubitz G, Hill MD, James A, Jeerakathil T, Jin A, Kirton A, Lanthier S, Lausman A, Leffert LR, Mandzia J, Menon B, Pikula A, Poppe A, Potts J, Ray J, Saposnik G, Sharma M, Smith EE, Bhogal S, Smitko E, Lindsay MP. Canadian stroke best practice consensus statement: Secondary stroke prevention during pregnancy. International Journal Of Stroke 2017, 13: 406-419. PMID: 29171360, DOI: 10.1177/1747493017743801.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsAntihypertensive AgentsCanadaCounselingDiabetes, GestationalDiabetic AngiopathiesFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypertensionIschemic Attack, TransientPlatelet Aggregation InhibitorsPostnatal CarePreconception CarePregnancyPregnancy Complications, CardiovascularPregnancy in DiabeticsPrenatal CareProfessional PracticeRisk FactorsSecondary PreventionStrokeConceptsSecondary stroke preventionStroke preventionConsensus statementUse of antithromboticsTransient ischemic attackBlood pressure managementIschemic stroke etiologyAspects of pregnancyHealth care professionalsGeneral management considerationsBest available literatureIschemic attackRecurrent strokeLipid managementStroke etiologyStroke riskFetal healthMaternal healthPrior historyFetal wellbeingCare professionalsClinical considerationsPregnancyConsensus documentExpert consensusThe incidence of pregnancy-related stroke: A systematic review and meta-analysis
Swartz RH, Cayley ML, Foley N, Ladhani NNN, Leffert L, Bushnell C, McClure J, Lindsay MP. The incidence of pregnancy-related stroke: A systematic review and meta-analysis. International Journal Of Stroke 2017, 12: 687-697. PMID: 28884652, DOI: 10.1177/1747493017723271.Peer-Reviewed Original ResearchConceptsCerebral venous sinus thrombosisVenous sinus thrombosisPregnancy-related strokeSinus thrombosisStroke incidenceCrude rateSystematic reviewIncidence of strokeHigh-risk populationConclusions StrokePostpartum strokeNonhemorrhagic strokeIschemic strokePregnancy populationStroke riskPerinatal strokePooled analysisSubgroup analysisObstetrical careIncidence rateStroke typeOvid MEDLINEInclusion criteriaStroke ratePregnancyRisk Factors for Pregnancy-Associated Stroke in Women With Preeclampsia
Miller EC, Gatollari HJ, Too G, Boehme AK, Leffert L, Marshall RS, Elkind MSV, Willey JZ. Risk Factors for Pregnancy-Associated Stroke in Women With Preeclampsia. Stroke 2017, 48: 1752-1759. PMID: 28546324, PMCID: PMC5539968, DOI: 10.1161/strokeaha.117.017374.Peer-Reviewed Original ResearchConceptsPregnancy-associated strokeRisk factorsChronic hypertensionProthrombotic stateOdds ratioMultivariable conditional logistic regression modelsConditional logistic regression modelsNew York State hospitalsIndependent risk factorVascular risk factorsSeverity of preeclampsiaLogistic regression modelsRace/ethnicityPregnancy complicationsSevere preeclampsiaMultivariable analysisInpatient DatabaseProthrombotic conditionsPreeclampsiaHigh riskClose monitoringNew York State DepartmentState HospitalCoagulopathyBilling data
2016
Integrating the New Thromboprophylaxis Guidelines Into Obstetric Anesthesia Practice
Leffert L, Landau R. Integrating the New Thromboprophylaxis Guidelines Into Obstetric Anesthesia Practice. Anesthesia & Analgesia 2016, 123: 809-811. PMID: 27636568, DOI: 10.1213/ane.0000000000001567.Peer-Reviewed Original Research
2015
Patient Characteristics and Outcomes After Hemorrhagic Stroke in Pregnancy
Leffert LR, Clancy CR, Bateman BT, Cox M, Schulte PJ, Smith EE, Fonarow GC, Schwamm LH, Kuklina EV, George MG. Patient Characteristics and Outcomes After Hemorrhagic Stroke in Pregnancy. Circulation Cardiovascular Quality And Outcomes 2015, 8: s170-s178. PMID: 26515206, DOI: 10.1161/circoutcomes.115.002242.Peer-Reviewed Original ResearchConceptsStroke risk factorsSubarachnoid hemorrhage patientsHemorrhagic strokeRisk factorsHS patientsHospital mortalityHemorrhage patientsDiseases-Ninth Revision codesBlood pressure criteriaGuidelines-Stroke registryPregnancy-related strokeAssociation of pregnancyNonpregnant female patientsConditional logistic regressionFisher's exact testWilcoxon rank sum testRank sum testGuidelines-StrokeSevere preeclampsiaHome dischargeIschemic strokeNonpregnant womenPatient characteristicsRisk patientsIndependent ambulationWhat’s New in Obstetric Anesthesia
Leffert L. What’s New in Obstetric Anesthesia. Anesthesia & Analgesia 2015, 120: 1065-1073. PMID: 25811260, DOI: 10.1213/ane.0000000000000686.Peer-Reviewed Original ResearchAnesthesia, ObstetricalDelivery, ObstetricFemaleHumansHypertension, Pregnancy-InducedInfantInfant, NewbornMaternal HealthMaternal Health ServicesMaternal MortalityNeonatologyPerinatal MortalityPerinatologyPostpartum HemorrhagePregnancyPregnancy ComplicationsPregnancy OutcomeRisk AssessmentRisk FactorsHypertensive Disorders and Pregnancy-Related Stroke
Leffert LR, Clancy CR, Bateman BT, Bryant AS, Kuklina EV. Hypertensive Disorders and Pregnancy-Related Stroke. Obstetrics And Gynecology 2015, 125: 124-131. PMID: 25560114, PMCID: PMC4445352, DOI: 10.1097/aog.0000000000000590.Peer-Reviewed Original ResearchConceptsTraditional stroke risk factorsPregnancy-associated strokeHypertensive disordersPregnancy hospitalizationsStroke risk factorsStroke-related complicationsStroke riskRisk factorsOdds ratioNationwide Inpatient SampleCongenital heart diseaseCross-sectional studyComplication rateStroke hospitalizationsInpatient SampleHeart diseaseNationwide rateHospitalizationPregnancyStrokeLogistic regressionCongenital coagulationDisordersConfidence intervalsComplications
2014
Cardiac Arrest during Hospitalization for Delivery in the United States, 1998–2011
Mhyre JM, Tsen LC, Einav S, Kuklina EV, Leffert LR, Bateman BT. Cardiac Arrest during Hospitalization for Delivery in the United States, 1998–2011. Anesthesiology 2014, 120: 810-818. PMID: 24694844, PMCID: PMC4445354, DOI: 10.1097/aln.0000000000000159.Peer-Reviewed Original ResearchConceptsAmniotic fluid embolismCardiac arrestPotential etiologiesHeart failureCommon potential etiologyMaternal cardiac arrestNationwide Inpatient SampleDemographic risk factorsMaternal cardiopulmonary arrestHospital dischargeCardiopulmonary arrestU.S. hospitalizationsUnderlying etiologyInpatient SampleMaternal arrestRisk factorsHospitalizationSurvival rateEtiologySepsisEmbolismHemorrhageArrestPatientsSurvival
2012
The Association of Maternal Race and Ethnicity and the Risk of Postpartum Hemorrhage
Bryant A, Mhyre JM, Leffert LR, Hoban RA, Yakoob MY, Bateman BT. The Association of Maternal Race and Ethnicity and the Risk of Postpartum Hemorrhage. Anesthesia & Analgesia 2012, 115: 1127-1136. PMID: 22886840, DOI: 10.1213/ane.0b013e3182691e62.Peer-Reviewed Original ResearchOutcomes of hospitalization in pregnant women with CNS neoplasms: a population-based study
Terry AR, Barker FG, Leffert L, Bateman BT, Souter I, Plotkin SR. Outcomes of hospitalization in pregnant women with CNS neoplasms: a population-based study. Neuro-Oncology 2012, 14: 768-776. PMID: 22513749, PMCID: PMC3367848, DOI: 10.1093/neuonc/nos078.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBostonBrain NeoplasmsCesarean SectionChildDelivery, ObstetricFemaleFetal Growth RetardationFollow-Up StudiesHospitalizationHumansMaternal MortalityObstetric Labor, PrematurePregnancyPregnancy Complications, NeoplasticPregnancy OutcomeRetrospective StudiesRisk FactorsSpinal NeoplasmsSurvival RateYoung AdultConceptsBenign brain tumorsIntrauterine growth restrictionMalignant brain tumorsNationwide Inpatient SamplePopulation-based studyCNS neoplasmsBrain tumorsCaesarean deliveryPreterm laborSpine tumorsPregnancy outcomesMaternal mortalityPregnancy-related admissionsAdverse pregnancy outcomesRetrospective cohort studyOutcomes of hospitalizationLogistic regression modelsPregnancy complicationsCohort studyHyperemesis gravidarumSurgical patientsObstetric riskPregnant womenInpatient SampleGrowth restrictionPeripartum Subarachnoid Hemorrhage
Bateman B, Olbrecht V, Berman M, Minehart R, Schwamm L, Leffert L. Peripartum Subarachnoid Hemorrhage. Anesthesiology 2012, 116: 324-333. PMID: 22166951, DOI: 10.1097/aln.0b013e3182410b22.Peer-Reviewed Original ResearchConceptsSubarachnoid hemorrhageHypertensive disordersRisk factorsPregnancy-related admissionsIndependent risk factorIntracranial venous thrombosisNationwide Inpatient SampleAfrican American raceVariety of etiologiesRange of etiologiesSickle cell diseaseIdentified admissionsHospital deathMaternal morbidityNonpregnant patientsNonpregnant womenIndependent predictorsMalignant etiologySevere headacheVenous thrombosisNonpregnant controlsPregnancy resultsVenous bleedingInstitution experienceInpatient Sample
2010
The Epidemiology of Postpartum Hemorrhage in a Large, Nationwide Sample of Deliveries
Bateman BT, Berman MF, Riley LE, Leffert LR. The Epidemiology of Postpartum Hemorrhage in a Large, Nationwide Sample of Deliveries. Anesthesia & Analgesia 2010, 110: 1368-1373. PMID: 20237047, DOI: 10.1213/ane.0b013e3181d74898.Peer-Reviewed Original ResearchConceptsPostpartum hemorrhageUterine atonyRisk factorsCesarean deliveryRate of PPHCases of PPHIncidence of PPHSubstantial maternal morbidityIndependent risk factorClinical Modification codesNationwide Inpatient SampleLogistic regression modelingAntepartum haemorrhageDelivery complicationsHospital deathMaternal morbidityMaternal outcomesMultiple gestationsCommon complicationHospital admissionHypertensive diseaseCommon etiologyMaternal ageInpatient SampleContemporary epidemiology