2018
The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants
Leffert L, Butwick A, Carvalho B, Arendt K, Bates SM, Friedman A, Horlocker T, Houle T, Landau R, Dubois H, Fernando R, Houle T, Kopp S, Montgomery D, Pellegrini J, Smiley R, Toledo P. The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants. Anesthesia & Analgesia 2018, 126: 928-944. PMID: 29099429, DOI: 10.1213/ane.0000000000002530.Peer-Reviewed Original ResearchConceptsHigh-dose anticoagulantsConsensus statementMaternal deathsObstetric anesthesiaNeuraxial proceduresPerinatology Consensus StatementPharmacodynamics of anticoagulantsUse of thromboprophylaxisRisk-benefit discussionsKey preventive measuresObstetric populationObstetric surgeryCesarean deliveryNeuraxial analgesiaVenous thromboembolismAnesthetic managementObstetric patientsDifficult airwayNeuraxial anesthesiaGeneral anesthesiaPostpartum womenPregnant womenFetal harmPostpartum periodLeading cause
2015
Treatment patterns and short-term outcomes in ischemic stroke in pregnancy or postpartum period
Leffert LR, Clancy CR, Bateman BT, Cox M, Schulte PJ, Smith EE, Fonarow GC, Kuklina EV, George MG, Schwamm LH. Treatment patterns and short-term outcomes in ischemic stroke in pregnancy or postpartum period. American Journal Of Obstetrics And Gynecology 2015, 214: 723.e1-723.e11. PMID: 26709084, DOI: 10.1016/j.ajog.2015.12.016.Peer-Reviewed Original ResearchConceptsAcute stroke reperfusion therapyStroke reperfusion therapyShort-term outcomesTissue plasminogen activatorGuidelines-Stroke registryPregnancy-related strokeReperfusion therapyIschemic stroke patientsIschemic strokeNonpregnant womenPostpartum womenStroke patientsPlasminogen activatorPostpartum periodIntravenous tissue plasminogen activator useIntravenous tissue plasminogen activatorFavorable short-term outcomesTissue plasminogen activator useAcute reperfusion therapyCatheter-based thrombolysisGreater stroke severityMajor systemic bleedingNonpregnant women 18Symptomatic intracranial hemorrhageHistory of hypertension
2013
Clinical care for opioid-using pregnant and postpartum women: the role of obstetric providers
Jones HE, Deppen K, Hudak ML, Leffert L, McClelland C, Sahin L, Starer J, Terplan M, Thorp JM, Walsh J, Creanga AA. Clinical care for opioid-using pregnant and postpartum women: the role of obstetric providers. American Journal Of Obstetrics And Gynecology 2013, 210: 302-310. PMID: 24120973, PMCID: PMC7213596, DOI: 10.1016/j.ajog.2013.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBuprenorphineConfidentialityDose-Response Relationship, DrugEmergency Service, HospitalFemaleHumansLabor PainLabor, ObstetricMental DisordersMethadoneNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersPain, PostoperativePhysician-Patient RelationsPostnatal CarePregnancyPregnancy ComplicationsPrenatal CareReferral and ConsultationTriageConceptsPregnant womenObstetric providersPostpartum periodPregnant patientsMixed opioid agonist/antagonistOpioid-dependent pregnant patientsOpioid-dependent pregnant womenOpioid agonist/antagonistHigh-quality obstetric careMedication-assisted withdrawalTherapeutic opioid useAcute pain managementHigh relapse rateDrug use disordersClinical care issuesIntense medical careBest possible outcomeOpioid withdrawalOpioid usePain managementRelapse rateObstetric carePostpartum womenComprehensive careClinical careEpidemiology of Obstetric-Related ICU Admissions in Maryland
Wanderer JP, Leffert LR, Mhyre JM, Kuklina EV, Callaghan WM, Bateman BT. Epidemiology of Obstetric-Related ICU Admissions in Maryland. Critical Care Medicine 2013, 41: 1844-1852. PMID: 23648568, PMCID: PMC3716838, DOI: 10.1097/ccm.0b013e31828a3e24.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, InducedAdolescentAdultAnesthesia, ObstetricalBlack PeopleCerebrovascular DisordersEmergency Service, HospitalFemaleHeart DiseasesHumansInfectionsIntensive Care UnitsLength of StayLiver FailureMarylandMaternal AgeMedicaidPatient AdmissionPatient TransferPregnancyPregnancy ComplicationsPregnancy, EctopicPuerperal DisordersPulmonary EmbolismRespiratory InsufficiencyUnited StatesWounds and InjuriesYoung AdultConceptsICU admissionPregnancy-related hypertensive diseaseRate of sepsisCritical care managementAppropriate International ClassificationClinical Modification codesTransfer of womenEctopic pregnancyAnesthetic complicationsHypertensive diseaseICU populationICU utilizationPostpartum patientsPulmonary embolismGenitourinary infectionsSevere morbidityCommon diagnosisCerebrovascular diseaseObstetric servicesPostpartum periodPostpartum conditionsCardiac diseaseInternational ClassificationAdmissionCare management