2020
Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs
Luo J, Qin L, Zhao L, Gui L, Ellis MW, Huang Y, Kural MH, Clark JA, Ono S, Wang J, Yuan Y, Zhang SM, Cong X, Li G, Riaz M, Lopez C, Hotta A, Campbell S, Tellides G, Dardik A, Niklason LE, Qyang Y. Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs. Cell Stem Cell 2020, 26: 251-261.e8. PMID: 31956039, PMCID: PMC7021512, DOI: 10.1016/j.stem.2019.12.012.Peer-Reviewed Original ResearchMeSH KeywordsBlood Vessel ProsthesisHumansInduced Pluripotent Stem CellsMyocytes, Smooth MuscleTissue Engineering
2016
Implantable tissue-engineered blood vessels from human induced pluripotent stem cells
Gui L, Dash BC, Luo J, Qin L, Zhao L, Yamamoto K, Hashimoto T, Wu H, Dardik A, Tellides G, Niklason LE, Qyang Y. Implantable tissue-engineered blood vessels from human induced pluripotent stem cells. Biomaterials 2016, 102: 120-129. PMID: 27336184, PMCID: PMC4939127, DOI: 10.1016/j.biomaterials.2016.06.010.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsVascular diseaseBlood vesselsAlpha-smooth muscle actinSmooth muscle myosin heavy chainActive vascular remodelingSmooth muscle cellsMuscle myosin heavy chainTissue-engineered blood vesselsStem cellsAbundant collagenous matrixPluripotent stem cellsInterposition graftAllogeneic graftsVascular remodelingΑ-SMANude ratsMuscle actinMyosin heavy chainClinical useMuscle cellsFunctional vascular smooth muscle cellsPatientsFunctional tissue-engineered blood vesselGraft
2014
Tissue‐Engineered Vascular Grafts Created From Human Induced Pluripotent Stem Cells
Sundaram S, One J, Siewert J, Teodosescu S, Zhao L, Dimitrievska S, Qian H, Huang AH, Niklason L. Tissue‐Engineered Vascular Grafts Created From Human Induced Pluripotent Stem Cells. Stem Cells Translational Medicine 2014, 3: 1535-1543. PMID: 25378654, PMCID: PMC4250208, DOI: 10.5966/sctm.2014-0065.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, DifferentiationBlood Vessel ProsthesisCell LineExtracellular MatrixHumansInduced Pluripotent Stem CellsTissue EngineeringConceptsPluripotent stem cellsMesenchymal lineagesSmooth muscle cell differentiationMuscle cell differentiationStem cellsInduced pluripotent stem cellsNeural crest intermediateHuman induced pluripotent stem cellsMesenchymal progenitor cellsStem cell clonesCollagen-rich matrixCell differentiationVascular developmentHiPSC linesProgenitor cellsSmooth muscle cellsCell apoptosisHiPS cellsLineagesMesenchymal markersGeneration of graftMuscle cellsClonesTissue-engineered vascular graftsCells
2011
Development of Novel Biodegradable Polymer Scaffolds for Vascular Tissue Engineering
Gui L, Zhao L, Spencer RW, Burghouwt A, Taylor MS, Shalaby SW, Niklason LE. Development of Novel Biodegradable Polymer Scaffolds for Vascular Tissue Engineering. Tissue Engineering Part A 2011, 17: 1191-1200. PMID: 21143045, PMCID: PMC3079248, DOI: 10.1089/ten.tea.2010.0508.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAnimalsBlood Vessel ProsthesisMaterials TestingPolymersSwineTissue EngineeringTissue ScaffoldsConceptsTissue engineering approachesTissue-engineered blood vesselsBiodegradable polymer scaffoldsVascular tissue engineeringPolyglycolic acidDegradation profileTissue mechanicsEngineering approachVessel mechanicsPolymers IIIPolymer scaffoldsBiodegradable scaffoldsTissue engineeringPolymeric materialsDegradation characteristicsMatrix-rich tissuesSynthetic polymersPolymer IPolymer IIPolymer fragmentsAqueous conditionsPolymersPotential applicationsSimilar degradation profilesMechanics