2020
Risk Factors and Precipitants of Severe Disability Among Community-Living Older Persons
Gill TM, Han L, Gahbauer EA, Leo-Summers L, Murphy TE. Risk Factors and Precipitants of Severe Disability Among Community-Living Older Persons. JAMA Network Open 2020, 3: e206021. PMID: 32484551, PMCID: PMC7267844, DOI: 10.1001/jamanetworkopen.2020.6021.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overConnecticutDisability EvaluationDisabled PersonsEmergency Service, HospitalFemaleGlobal Burden of DiseaseHospitalizationHumansMaleProspective StudiesQuality of LifeRecovery of FunctionRisk FactorsSeverity of Illness IndexWounds and InjuriesConceptsEmergency department visitsRisk factorsCatastrophic disabilitySevere disabilityDepartment visitsProgressive disabilityOlder community-living adultsCommunity-living older personsIndependent risk factorProspective cohort studyCommunity-living personsGreater New HavenCommunity-living adultsPotential risk factorsCandidate risk factorsNon-Hispanic white participantsQuality of lifeLong-term careCohort studyMultivariable analysisMean ageFunctional statusMAIN OUTCOMEPotential precipitantsDaily livingDisability and Recovery After Hospitalization for Medical Illness Among Community‐Living Older Persons: A Prospective Cohort Study
Dharmarajan K, Han L, Gahbauer EA, Leo‐Summers L, Gill TM. Disability and Recovery After Hospitalization for Medical Illness Among Community‐Living Older Persons: A Prospective Cohort Study. Journal Of The American Geriatrics Society 2020, 68: 486-495. PMID: 32083319, PMCID: PMC7735402, DOI: 10.1111/jgs.16350.Peer-Reviewed Original ResearchConceptsAcute medical illnessProspective cohort studyMedical illnessNew disabilityCohort studySelf-managing health conditionsCommunity-living older personsHealth conditionsImmediate transitional periodCommunity-living personsPost-discharge careChronic health conditionsMean recovery timeSubgroup of personsMobility activitiesIncident disabilityHospital dischargePeriod of vulnerabilityMonth 2Follow-up interviewHospitalizationDisability prevalenceOlder personsPrior monthIllness
2019
Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfection
2018
Prognostic Effect of Changes in Physical Function Over Prior Year on Subsequent Mortality and Long‐Term Nursing Home Admission
Gill TM, Han L, Gahbauer EA, Leo‐Summers L, Allore HG. Prognostic Effect of Changes in Physical Function Over Prior Year on Subsequent Mortality and Long‐Term Nursing Home Admission. Journal Of The American Geriatrics Society 2018, 66: 1587-1591. PMID: 29719039, PMCID: PMC6133765, DOI: 10.1111/jgs.15399.Peer-Reviewed Original ResearchConceptsLong-term nursing home admissionNursing home admissionHome admissionPhysical functionDisability scoresPrognostic effectDaily livingPrior yearCommunity-living personsRisk of deathUseful prognostic informationProspective longitudinal studyAdverse outcomesPrognostic informationMultivariable modelInstrumental activitiesSubsequent mortalityAdmissionBivariate predictorsSubsequent outcomesMonthsDifferent intervalsComprehensive assessmentDeathLongitudinal study
2017
Distressing Symptoms, Disability, and Hospice Services at the End of Life: Prospective Cohort Study
Gill TM, Han L, Leo‐Summers L, Gahbauer EA, Allore HG. Distressing Symptoms, Disability, and Hospice Services at the End of Life: Prospective Cohort Study. Journal Of The American Geriatrics Society 2017, 66: 41-47. PMID: 28895118, PMCID: PMC5777867, DOI: 10.1111/jgs.15041.Peer-Reviewed Original ResearchConceptsProspective cohort studyEnd of lifeHospice admissionCohort studyDistressing symptomsHospice servicesMonths of lifeNumber of disabilitiesMedian durationSubsequent admissionHigh burdenMedicare claimsAdditional disabilitiesAdmissionAdditional monthsSymptomsOlder personsHospiceMonthly interviewsMonthsDisabilityShort durationAdditional strategiesDurationNew Haven
2015
The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people
Gill TM, Gahbauer EA, Han L, Allore HG. The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people. The BMJ 2015, 350: h2361. PMID: 25995357, PMCID: PMC4443433, DOI: 10.1136/bmj.h2361.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedCohort StudiesConnecticutDementiaDisability EvaluationDisabled PersonsDisease ProgressionFemaleFrail ElderlyGeriatric AssessmentHospitalizationHumansMaleMultiple Organ FailureNeoplasmsPrognosisProspective StudiesSeverity of Illness IndexTerminal CareUnited StatesConceptsCourse of disabilityProspective cohort studyHospital admissionTrajectories of disabilitySeverity of disabilityCatastrophic disabilitySevere disabilityCohort studyAcute hospital admissionPalliative care approachMultiple hospital admissionsAdvance care planningPersonal care needsEnd of lifeDisability scoresOlder patientsPotential confoundersOccurrence of admissionMultivariable modelCare planningMAIN OUTCOMECare approachDaily livingCare needsAdmissionA Longitudinal, Observational Study with Many Repeated Measures Demonstrated Improved Precision of Individual Survival Curves Using Bayesian Joint Modeling of Disability and Survival
Murphy TE, Allore HG, Han L, Peduzzi PN, Gill TM, Xu X, Lin H. A Longitudinal, Observational Study with Many Repeated Measures Demonstrated Improved Precision of Individual Survival Curves Using Bayesian Joint Modeling of Disability and Survival. Experimental Aging Research 2015, 41: 221-239. PMID: 25978444, PMCID: PMC4452025, DOI: 10.1080/0361073x.2015.1021640.Peer-Reviewed Original Research
2014
Restricting Back Pain and Subsequent Mobility Disability in Community‐Living Older Persons
Makris UE, Fraenkel L, Han L, Leo‐Summers L, Gill TM. Restricting Back Pain and Subsequent Mobility Disability in Community‐Living Older Persons. Journal Of The American Geriatrics Society 2014, 62: 2142-2147. PMID: 25366926, PMCID: PMC4241131, DOI: 10.1111/jgs.13089.Peer-Reviewed Original ResearchConceptsBaseline mobility disabilityBack painMobility disabilityOlder personsCommunity-living older personsPersistent mobility disabilityProspective cohort studyCox regression analysisMonthly telephone interviewsCommunity-living menDisability episodeCohort studyPainCox modelSecondary analysisEvent ratesTelephone interviewsMonthsDisabilityConsecutive monthsRegression analysisAssociationNew HavenPersonsParticipantsEpidemiology of Restricting Fatigue in Older Adults: The Precipitating Events Project
de Rekeneire N, Leo‐Summers L, Han L, Gill TM. Epidemiology of Restricting Fatigue in Older Adults: The Precipitating Events Project. Journal Of The American Geriatrics Society 2014, 62: 476-481. PMID: 24512073, PMCID: PMC4103720, DOI: 10.1111/jgs.12685.Peer-Reviewed Original ResearchConceptsCommunity-living older adultsPhysical frailtyOlder adultsCommunity-living older menEpidemiologic Studies Depression ScaleProspective cohort studySlow gait speedOverall incidence ratePrecipitating Events ProjectCohort studyCumulative incidenceMedian durationGait speedIncidence rateDepression ScaleUsual activitiesOlder menFrailtyDepressionMonthsWomenConsecutive monthsAdultsHigh rateRespective counterparts
2013
Risk Factors for Restricting Back Pain in Older Persons
Makris UE, Fraenkel L, Han L, Leo-Summers L, Gill TM. Risk Factors for Restricting Back Pain in Older Persons. Journal Of The American Medical Directors Association 2013, 15: 62-67. PMID: 24239445, PMCID: PMC3872215, DOI: 10.1016/j.jamda.2013.09.013.Peer-Reviewed Original ResearchConceptsPersistent/recurrentCandidate risk factorsRisk factorsBack painOlder personsFemale sexComprehensive home-based assessmentsMultivariable Cox modelProspective cohort studyMonthly telephone interviewsMore chronic conditionsWeak grip strengthHome-based assessmentHip weaknessCohort studyCumulative incidenceIncident episodesMultivariable analysisProspective studyGrip strengthChronic conditionsPainCox modelDepressive symptomsRestricted activity
2011
Antidepressant Use and Cognitive Deficits in Older Men: Addressing Confounding by Indications with Different Methods
Han L, Kim N, Brandt C, Allore HG. Antidepressant Use and Cognitive Deficits in Older Men: Addressing Confounding by Indications with Different Methods. Annals Of Epidemiology 2011, 22: 9-16. PMID: 22037381, PMCID: PMC4054866, DOI: 10.1016/j.annepidem.2011.10.004.Peer-Reviewed Original ResearchConceptsDepression-related diagnosisAntidepressant useDepression symptomsOlder personsPropensity scoreHopkins Verbal Learning TestHypertensive menAntidepressant medicationIndication biasVerbal Learning TestMedical recordsPotential confoundingCumulative exposureOlder menCognitive impairmentMemory deficitsCognitive deficitsMultiple linear regressionLinear regressionLearning TestApparent associationScoresSymptomsDiagnosisIndicationsEpidemiology of Restricting Back Pain in Community‐Living Older Persons
Makris UE, Fraenkel L, Han L, Leo‐Summers L, Gill TM. Epidemiology of Restricting Back Pain in Community‐Living Older Persons. Journal Of The American Geriatrics Society 2011, 59: 610-614. PMID: 21410444, PMCID: PMC3098613, DOI: 10.1111/j.1532-5415.2011.03329.x.Peer-Reviewed Original ResearchConceptsCommunity-living older personsCumulative incidenceBack painIncidence rateOlder personsFirst episodeBaseline age groupProspective cohort studyKaplan-Meier methodCommunity-living menPoisson regression modelsCohort studyMedian durationMedian timeDescriptive epidemiologyTotal episodesOlder womenPainOlder menAge groupsRestricted activityIncidenceWomenMenConsecutive months
2007
Bath Aids and the Subsequent Development of Bathing Disability in Community‐Living Older Persons
Gill TM, Han L, Allore HG. Bath Aids and the Subsequent Development of Bathing Disability in Community‐Living Older Persons. Journal Of The American Geriatrics Society 2007, 55: 1757-1763. PMID: 17916117, PMCID: PMC2778072, DOI: 10.1111/j.1532-5415.2007.01421.x.Peer-Reviewed Original ResearchEffects of Statin Use on Muscle Strength, Cognition, and Depressive Symptoms in Older Adults
Agostini JV, Tinetti ME, Han L, McAvay G, Foody JM, Concato J. Effects of Statin Use on Muscle Strength, Cognition, and Depressive Symptoms in Older Adults. Journal Of The American Geriatrics Society 2007, 55: 420-425. PMID: 17341246, DOI: 10.1111/j.1532-5415.2007.01071.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCognitionCohort StudiesComorbidityConnecticutDepressionDrug Therapy, CombinationDrug UtilizationFemaleGeriatric AssessmentHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLongitudinal StudiesMaleMuscle StrengthNeuropsychological TestsPrimary Health CareProspective StudiesRisk AssessmentVeteransConceptsStatin usersMuscle strengthTest Part BStatin useDepression scoresEpidemiologic Studies Depression Scale scoreOutpatient primary care clinicsOlder adultsConcomitant medication useProximal muscle strengthObservational cohort studyPeripheral vascular diseasePrimary care clinicsDepression Scale scoresHigh-risk participantsHydroxymethyl glutaryl coenzymeCommunity-dwelling veteransCommunity-dwelling male participantsGreater comorbidityStatin therapyCohort studyMedian durationStatin prescriptionMedication useCare clinicsPredisposing Factors and Precipitants for Bathing Disability in Older Persons
Gill TM, Han L, Allore HG. Predisposing Factors and Precipitants for Bathing Disability in Older Persons. Journal Of The American Geriatrics Society 2007, 55: 534-540. PMID: 17397431, DOI: 10.1111/j.1532-5415.2007.01099.x.Peer-Reviewed Original ResearchConceptsBathing disabilityPersistent disabilityPredisposing factorsPotential precipitantsComprehensive home-based assessmentsOlder personsCommunity-living older personsCommunity-living residentsMultivariable hazard ratiosProspective cohort studyLow physical activityMonthly telephone interviewsPotential predisposing factorsHome-based assessmentCohort studyHazard ratioPhysical activityRestricted activityTelephone interviewsStrong associationDisabilityHospitalizationInjuryIllnessSuitable target
2004
The Relationship Between Number of Medications and Weight Loss or Impaired Balance in Older Adults
Agostini JV, Han L, Tinetti ME. The Relationship Between Number of Medications and Weight Loss or Impaired Balance in Older Adults. Journal Of The American Geriatrics Society 2004, 52: 1719-1723. PMID: 15450051, DOI: 10.1111/j.1532-5415.2004.52467.x.Peer-Reviewed Original ResearchConceptsImpaired balanceOdds ratioWeight lossCumulative medication exposureNumber of medicationsAdjusted odds ratioNumber of hospitalizationsAdverse drug effectsCommunity-dwelling residentsAdverse drug outcomesTotal drug useMedication exposureMore medicationsIndividual medicationsCommon manifestationChronic diseasesChronic illnessLongitudinal cohortMedicationsDepressive symptomsDrug effectsCognitive impairmentDrug useHearing impairmentExtensive adjustment