Featured Publications
The association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis
Scierka LE, Mena-Hurtado C, Ahmed ZV, Yousef S, Arham A, Grimshaw AA, Harris KM, Burg M, Vriens PW, Heyligers J, Lee M, Yazgan I, Smolderen KG. The association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis. Journal Of Affective Disorders 2022, 320: 169-177. PMID: 36179780, DOI: 10.1016/j.jad.2022.09.098.Peer-Reviewed Original ResearchConceptsMajor adverse limb eventsPeripheral artery diseaseAssociation of depressionCause mortalityArtery diseaseDepressive symptomsSystematic reviewAdverse limb eventsAdverse prognostic outcomeCoronary artery diseaseRisk of biasImportant comorbidityPoor outcomeAdverse outcomesPrognostic outcomesPooled resultsRisk factorsObservational studyTreatment statusLimb eventsDepression severityPatientsLarger sample sizeMortalityRisk estimatesThe shifting care and outcomes for patients with endangered limbs – Critical limb ischemia (SCOPE-CLI) registry overview of study design and rationale
Scierka LE, Mena-Hurtado C, Shishehbor MH, Spertus JA, Nagpal S, Babrowski T, Bunte MC, Politano A, Humphries M, Chung J, Kirksey L, Alabi O, Soukas P, Parikh S, Faizer R, Fitridge R, Provance J, Romain G, McMillan N, Stone N, Scott K, Fuss C, Pacheco CM, Gosch K, Harper-Brooks A, Smolderen KG, Consortium O. The shifting care and outcomes for patients with endangered limbs – Critical limb ischemia (SCOPE-CLI) registry overview of study design and rationale. IJC Heart & Vasculature 2022, 39: 100971. PMID: 35198727, PMCID: PMC8850321, DOI: 10.1016/j.ijcha.2022.100971.Peer-Reviewed Original ResearchCritical limb ischemiaTreatment preferencesPeripheral artery diseaseProspective observational registryPatient-centered outcomesPatterns of carePoor wound healingHealth status outcomesProcess of careCLI careObservational registryLimb ischemiaPatient characteristicsArtery diseaseVascular centersVital statusMean agePatient preferencesPatient's perspectiveSevere formPatientsPsychosocial factorsStatus outcomesHealth statusCare experiences
2024
Association of health status and hospitalization risk for peripheral artery disease in the PORTRAIT registry.
Cleman J, Romain G, Scierka L, Labrosciano C, Bradley B, Fitridge R, Beltrame J, Shishehbor M, Spertus J, Mena-Hurtado C, Smolderen K. Association of health status and hospitalization risk for peripheral artery disease in the PORTRAIT registry. Vascular Medicine 2024, 1358863x241274758. PMID: 39319857, DOI: 10.1177/1358863x241274758.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral arterial diseaseED visitsHealth statusHospital admissionHealthcare utilizationPAD-specific health statusEmergency departmentCause-specific hospital admissionsAssociation of health statusPatient-reported outcome measuresPatient's risk of hospitalizationBaseline health statusAll-cause hospital admissionsCox proportional hazards modelsRisk of hospitalizationOverall summary scorePAQ scoresProportional hazards modelSummary scoreOutcome measuresHospitalization riskArtery diseaseVisitsHazards modelASSOCIATION BETWEEN DEPRESSIVE SYMPTOMS AND HEALTH STATUS OUTCOMES IN PATIENTS WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE
Jacque F, Romain G, Peri-Okonny P, Sinusas A, Callegari S, Cleman J, Scierka L, Mares A, Hurtado C, Smolderen K. ASSOCIATION BETWEEN DEPRESSIVE SYMPTOMS AND HEALTH STATUS OUTCOMES IN PATIENTS WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE. Journal Of The American College Of Cardiology 2024, 83: 2308. DOI: 10.1016/s0735-1097(24)04298-0.Peer-Reviewed Original ResearchExamining Outcomes in Patients Admitted With Comorbid Peripheral Artery Disease and Microvascular Disease
Grubman S, Algara M, Smolderen K, Luna P, Walenczyk K, Scierka L, Cleman J, Siddiqui W, Romain G, Mena‐Hurtado C. Examining Outcomes in Patients Admitted With Comorbid Peripheral Artery Disease and Microvascular Disease. Journal Of The American Heart Association 2024, 13: e030710. PMID: 38166496, PMCID: PMC10863818, DOI: 10.1161/jaha.123.030710.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseMajor adverse cardiac eventsAdverse cardiac eventsMicrovascular diseaseMinor amputationHospital mortalityCardiac eventsArtery diseaseNational Readmission DatabaseFurther prospective researchNumber of patientsCommon risk factorsMultiple logistic regressionMajor amputationBaseline factorsFinal cohortCox regressionAdverse outcomesPAD groupSecondary diagnosisRisk factorsAnnual admissionsObservational studyPrevalent conditionHigh risk
2023
“Zoom”ing to the Kitchen: A Novel Approach to Virtual Nutrition Education for Medical Trainees
Charles J, Wood N, Neary S, Moreno J, Scierka L, Brink B, Zhao X, Gielissen K. “Zoom”ing to the Kitchen: A Novel Approach to Virtual Nutrition Education for Medical Trainees. Nutrients 2023, 15: 4166. PMID: 37836450, PMCID: PMC10574391, DOI: 10.3390/nu15194166.Peer-Reviewed Original ResearchConceptsNutrition educationFirst-line therapyCoronary artery diseaseType 2 diabetesNutrition-related knowledgeMedical traineesPlant-based nutritionArtery diseaseNutrition counselingNutritional interventionChronic diseasesCulinary medicineDietary behaviorsKnowledge scoreNutritional issuesDietary changesPhysician assistant studentsTeaching kitchenNutrition curriculumAssistant studentsDiseaseWeeksCounselingPA studentsTraineesObesity prevalence and variability in management practices for patients with symptomatic peripheral artery disease
Scierka L, Peri-Okonny P, Romain G, Mena-Hurtado C, Smolderen K. Obesity prevalence and variability in management practices for patients with symptomatic peripheral artery disease. Obesity Research & Clinical Practice 2023, 17: 264-268. PMID: 37225553, DOI: 10.1016/j.orcp.2023.05.002.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseWeight loss medicationsObesity management strategiesMedian odds ratioDietary counselingLower extremity peripheral arterial diseaseSymptomatic peripheral artery diseaseDietary management strategiesSymptomatic PAD patientsPeripheral artery diseaseObesity prevalence ratesPrevalence of obesityPoor disease outcomeModifiable comorbiditiesPORTRAIT registryPAD patientsArtery diseaseArterial diseaseTreatment modalitiesObesity prevalenceOdds ratioDisease outcomePrevalence ratesPAD managementObesity
2022
Real‐world VASCADE closure device versus manual compression use and outcomes in patients with severe common femoral artery disease
Nagpal S, Scierka LE, Castro‐Dominguez Y, Kansal D, Kunnirickal S, Hussain Y, Love K, Aboian E, Smolderen KG, Mena‐Hurtado C. Real‐world VASCADE closure device versus manual compression use and outcomes in patients with severe common femoral artery disease. Catheterization And Cardiovascular Interventions 2022, 100: 776-784. PMID: 36129818, DOI: 10.1002/ccd.30405.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsManual compressionClosure deviceCommon femoral artery diseaseVascular Quality Initiative databaseFemoral artery diseasePropensity-matched cohortPseudoaneurysm rateRetroperitoneal bleedingArtery diseaseRetrospective reviewMean ageBaseline variablesInstitutional databaseNonsignificant reductionNonsignificant decreaseVascular interventionsMortality ratePatientsCompression useCollagen plugDiseaseInitiative databaseProcedural metricsDevice use
2021
Patient representativeness of a peripheral artery disease cohort in a randomized control trial versus a real-world cohort: The CLEVER trial versus the PORTRAIT registry
Scierka LE, Jelani QU, Smolderen KG, Gosch K, Spertus JA, Mena-Hurtado C, Jones P, Dreyer RP. Patient representativeness of a peripheral artery disease cohort in a randomized control trial versus a real-world cohort: The CLEVER trial versus the PORTRAIT registry. Contemporary Clinical Trials 2021, 112: 106624. PMID: 34793986, DOI: 10.1016/j.cct.2021.106624.Peer-Reviewed Original ResearchConceptsOptimal medical therapyPeripheral artery diseasePatient characteristicsBaseline patient characteristicsPAD cohortPAD populationPORTRAIT registryExercise therapyPAD patientsPAD symptomsArtery diseaseFinal cohortMedical therapyProspective studyBurdensome diseaseControl trialHealth statusPatientsTherapyCohortCLEVER studyDiseaseMulticenterRevascularizationRCTsAssociation of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study
Jelani QU, Mena-Hurtado C, Gosch K, Mohammed M, Labrosciano C, Regan C, Scierka LE, Spertus JA, Nagpal S, Smolderen KG. Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study. PLOS ONE 2021, 16: e0256933. PMID: 34506511, PMCID: PMC8432750, DOI: 10.1371/journal.pone.0256933.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePeripheral Artery QuestionnaireSleep apneaHealth statusArtery diseaseSummary scoresDisease-specific Peripheral Artery QuestionnaireFive-year survival curvesHigh ankle-brachial indexPAQ summary scoreVascular specialty clinicsAnkle-brachial indexLog-rank testSleep apnea statusHealth status outcomesWorse health statusQuality of lifeBetter health statusCause mortalityMultivariable adjustmentPAD symptomsCoronary diseasePeripheral interventionsUS patientsMean age