2012
Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy
Bockenstedt LK, Gonzalez DG, Haberman AM, Belperron AA. Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy. Journal Of Clinical Investigation 2012, 122: 2652-2660. PMID: 22728937, PMCID: PMC3386809, DOI: 10.1172/jci58813.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsAntigens, BacterialArthritis, InfectiousBacterial LoadBorrelia burgdorferiCartilageCeftriaxoneDoxycyclineEar, ExternalFemaleFluorescence Recovery After PhotobleachingGreen Fluorescent ProteinsJoint CapsuleLyme DiseaseMiceMice, Inbred C3HMice, Inbred C57BLMice, KnockoutMicroscopy, Fluorescence, MultiphotonMyeloid Differentiation Factor 88PatellaRecombinant ProteinsConceptsNaive miceAntibiotic treatmentIntravital microscopyAntibiotic-refractory Lyme arthritisLyme diseaseTNF-α productionBorrelia burgdorferi antigensB. burgdorferi antigensSpirochete antigenTLR responsivenessInflammatory arthritisAntibiotic therapyLyme arthritisWT miceMusculoskeletal symptomsAntigens persistSlow resolutionImmunodeficient miceMouse modelTissue transplantsPathogen burdenSpirochete DNAInfectious spirochetesLyme borreliosisMice
1998
Modulation of Murine Lyme Borreliosis by Interruption of the B7/CD28 T-Cell Costimulatory Pathway
Shanafelt M, Kang I, Barthold S, Bockenstedt L. Modulation of Murine Lyme Borreliosis by Interruption of the B7/CD28 T-Cell Costimulatory Pathway. Infection And Immunity 1998, 66: 266-271. PMID: 9423867, PMCID: PMC107886, DOI: 10.1128/iai.66.1.266-271.1998.Peer-Reviewed Original ResearchAbataceptAnimalsAntibodies, BacterialAntibodies, BlockingAntigens, CDAntigens, DifferentiationArthritis, InfectiousB7-1 AntigenB7-2 AntigenCD28 AntigensCTLA-4 AntigenFemaleImmunoconjugatesImmunoglobulin GInterferon-gammaInterleukin-4Lyme DiseaseLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CSpecific Pathogen-Free OrganismsTh1 CellsTh2 CellsUp-Regulation