2024
Persistent Cutaneous Lesions of Darier Disease and Second-Hit Somatic Variants in ATP2A2 Gene
Atzmony L, Zagairy F, Mawassi B, Shehade M, Tatour Y, Danial-Farran N, Khayat M, Warrour N, Dodiuk-Gad R, Cohen-Barak E. Persistent Cutaneous Lesions of Darier Disease and Second-Hit Somatic Variants in ATP2A2 Gene. JAMA Dermatology 2024, 160: 518-524. PMID: 38536168, PMCID: PMC10974685, DOI: 10.1001/jamadermatol.2024.0152.Peer-Reviewed Original ResearchConceptsSomatic variantsATP2A2 geneDeep sequencingResponse to environmental factorsCopy number variantsRestriction fragment length polymorphismLoss of heterozygosityWhole-exome sequencingChromosomal microarray analysisDarier's diseaseFragment length polymorphismPaired whole exome sequencingPathogenic germline variantsHeterozygous pathogenic germline variantsDD lesionsGenomic characteristicsGenetic analysisGenetic skin disordersGermline variantsSanger sequencingLength polymorphismSkin lesionsTransient lesionsHeterozygous variantsMicroarray analysis
2020
Treatment of Bullous Pemphigoid in People Aged 80 Years and Older: A Systematic Review of the Literature
Oren-Shabtai M, Kremer N, Lapidoth M, Sharon E, Atzmony L, Nosrati A, Hodak E, Mimouni D, Levi A. Treatment of Bullous Pemphigoid in People Aged 80 Years and Older: A Systematic Review of the Literature. Drugs & Aging 2020, 38: 125-136. PMID: 33230804, DOI: 10.1007/s40266-020-00823-5.Peer-Reviewed Original ResearchConceptsOlder patientsBullous pemphigoidTopical corticosteroidsCohort studyTreatment of bullous pemphigoidSide effect profileRetrospective cohort studyNational Institutes of Health databaseProspective cohort studySystematic reviewBackgroundBullous pemphigoidRandomized controlled trialsSignificant adverse effectsPartial responseSystemic corticosteroidsCase seriesTherapeutic optionsPatient selectionTreatment modalitiesAdverse eventsOlder adultsConclusionsCurrent dataPrimary outcomeSecondary outcomesUS National InstitutesClues to primary vismodegib resistance lie in histology and genetics
Sun Q, Atzmony L, Zaki T, Peng A, Sugarman J, Choate KA. Clues to primary vismodegib resistance lie in histology and genetics. Journal Of Clinical Pathology 2020, 73: 678-680. PMID: 32217615, PMCID: PMC7513245, DOI: 10.1136/jclinpath-2020-206448.Peer-Reviewed Original ResearchConceptsBasal cell carcinomaCommon human malignant neoplasmInfundibulocystic basal cell carcinomaBasal cell nevus syndromeHuman malignant neoplasmsWhole-exome sequencingClinical featuresBCC subtypesCell carcinomaMalignant neoplasmsHistological resultsHedgehog pathwayBiopsyVismodegibCarcinomaNeoplasmsSyndromeHistologyLesionsSubtypesMutationsBloodMutations in KRT10 in epidermolytic acanthoma
Cheraghlou S, Atzmony L, Roy SF, McNiff JM, Choate KA. Mutations in KRT10 in epidermolytic acanthoma. Journal Of Cutaneous Pathology 2020, 47: 524-529. PMID: 32045015, PMCID: PMC7914398, DOI: 10.1111/cup.13664.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingEpidermolytic acanthomaEpidermolytic hyperkeratosisHotspot mutationsCharacteristic histopathological patternEpidermolytic ichthyosisHistopathological patternsHistopathological analysisDiscovery cohortLesional tissueAdditional casesPolymerase chain reaction amplificationEpidermal degenerationChain reaction amplificationFragment length polymorphism analysisRestriction fragment length polymorphism analysisLength polymorphism analysisDermatosesIchthyosis bullosaAcanthomaKRT10Departmental archivesReaction amplificationIchthyosisPolymorphism analysis
2017
Risk for hepatitis B and C virus reactivation in patients with psoriasis on biologic therapies: A retrospective cohort study and systematic review of the literature
Snast I, Atzmony L, Braun M, Hodak E, Pavlovsky L. Risk for hepatitis B and C virus reactivation in patients with psoriasis on biologic therapies: A retrospective cohort study and systematic review of the literature. Journal Of The American Academy Of Dermatology 2017, 77: 88-97.e5. PMID: 28495497, DOI: 10.1016/j.jaad.2017.01.037.Peer-Reviewed Original ResearchConceptsChronic HBV infectionBiologic therapyHBV infectionViral reactivationAntiviral prophylaxisCore antibodyHCV infectionHepatitis BSafety of biologic therapiesHistory of viral hepatitisSystematic reviewIsolated core antibodyHBV core antibodyLow-risk patientsRetrospective cohort study designRetrospective cohort studyReactivated HBV infectionCohort study designPsoriasis patientsViral hepatitisEvaluate safetyFollow-upCohort studyPrimary outcomeTreatment durationVenous thromboembolism in patients with pemphigus: A cohort study
Leshem Y, Atzmony L, Dudkiewicz I, Hodak E, Mimouni D. Venous thromboembolism in patients with pemphigus: A cohort study. Journal Of The American Academy Of Dermatology 2017, 77: 256-260. PMID: 28495498, DOI: 10.1016/j.jaad.2017.01.059.Peer-Reviewed Original ResearchConceptsVenous thromboembolism riskDevelopment of venous thromboembolismVenous thromboembolism risk factorsVenous thromboembolismCharacteristics of venous thromboembolismRisk factorsAsymptomatic venous thromboembolismDeep vein thrombosesFollow-up timeVenous thromboembolic eventsPemphigus diagnosisPemphigus treatmentPatient yearsPulmonary embolismVein thrombosesCause of deathRetrospective studyThrombo-prophylaxisHealth recordsPatientsHigh riskPemphigusDiagnosed pemphigusControl populationThromboembolism
2016
New insights into folliculotropic mycosis fungoides (FMF): A single-center experience
Hodak E, Amitay-Laish I, Atzmony L, Prag-Naveh H, Yanichkin N, Barzilai A, Kershenovich R, Feinmesser M. New insights into folliculotropic mycosis fungoides (FMF): A single-center experience. Journal Of The American Academy Of Dermatology 2016, 75: 347-355. PMID: 27245278, DOI: 10.1016/j.jaad.2016.03.009.Peer-Reviewed Original ResearchConceptsFolliculotropic mycosis fungoidesMycosis fungoidesPattern of clinicopathological featuresAdvanced stageLong-term follow-upLack of long-term follow-upTertiary medical centerEarly-stage lesionsEarly-stage groupPresence of eosinophilsAggressive courseTumor stageClinicopathological presentationHistopathological discriminationPerifollicular infiltratePrognostic implicationsClinicopathological featuresInfiltration densityAcneiform lesionsClinical manifestationsIndurated plaquesFollow-upMultivariate analysisTumorMedical Center
2015
Cutaneous Polyarteritis Nodosa Associated with Destructive Arthritis.
Atzmony L, Feuerman H, Molad Y, Didkovsky Y, Hodak E. Cutaneous Polyarteritis Nodosa Associated with Destructive Arthritis. Israel Medical Association Journal 2015, 17: 587-8. PMID: 26625555.Peer-Reviewed Original ResearchErythrodermic mycosis fungoides and Sézary syndrome treated with extracorporeal photopheresis as part of a multimodality regimen: A single‐centre experience
Atzmony L, Amitay-Laish I, Gurion R, Shahal-Zimra Y, Hodak E. Erythrodermic mycosis fungoides and Sézary syndrome treated with extracorporeal photopheresis as part of a multimodality regimen: A single‐centre experience. Journal Of The European Academy Of Dermatology And Venereology 2015, 29: 2382-2389. PMID: 26299651, DOI: 10.1111/jdv.13243.Peer-Reviewed Original ResearchConceptsExtracorporeal photopheresisErythrodermic mycosis fungoidesSezary syndromeLeukaemic involvementMycosis fungoidesErythrodermic MFTreated with extracorporeal photopheresisBlood responseNarrow-band ultraviolet BSkin responsePatch-stage MFClinical response rateElectron beam radiotherapyTopical nitrogen mustardTertiary medical centreMultimodal approachBeam radiotherapyMultimodality regimenClinical responseAdjunctive therapyInterferon-aSurvival advantageMedical filesPhotopheresisPatients
2012
Symptomatic venous thromboembolism in elderly patients following major orthopedic surgery of the lower limb is associated with elevated vitamin B12 serum levels
Grossfeld A, Dekel S, Lerman Y, Sherman S, Atzmony L, Salai M, Justo D. Symptomatic venous thromboembolism in elderly patients following major orthopedic surgery of the lower limb is associated with elevated vitamin B12 serum levels. Clinical Biochemistry 2012, 46: 54-58. PMID: 23000313, DOI: 10.1016/j.clinbiochem.2012.09.011.Peer-Reviewed Original ResearchConceptsVitamin B12 serum levelsB12 serum levelsAssociated with systemic inflammationVenous thromboembolism risk factorsSymptomatic venous thromboembolismSerum levelsVenous thromboembolismElderly patientsStudy groupOrthopedic surgerySystemic inflammationControl groupCo-morbiditiesRisk factorsAssociated with venous thromboembolismPatients venous thromboembolismLower limbsRetrospective studyVTE patientsMedical chartsSurgeryPatientsIndependent of demographicsMortalityThromboembolism
2010
Incidence of Cytomegalovirus-associated thrombosis and its risk factors: A case-control study
Atzmony L, Halutz O, Avidor B, Finn T, Zimmerman O, Steinvil A, Zeltser D, Giladi M, Justo D. Incidence of Cytomegalovirus-associated thrombosis and its risk factors: A case-control study. Thrombosis Research 2010, 126: e439-e443. PMID: 20926120, DOI: 10.1016/j.thromres.2010.09.006.Peer-Reviewed Original ResearchConceptsAcute CMV infectionAssociated with thrombosisCMV infectionConsecutive patientsRisk factorsControl groupSex-matched consecutive patientsStudy groupCohort of patientsTertiary medical centerConsecutive matched patientsBinary logistic regression analysisLogistic regression analysisVenous thrombosesVenous thrombosisMatched patientsThrombosis incidenceInherited predispositionMedical chartsArterial thrombosisPhysician awarenessThrombosisAge-matchedPatientsMedical Center
2009
Inherited and acquired predispositions for thrombosis in immunocompetent patients with cytomegalovirus-associated thrombosis
Atzmony L, Grosfeld A, Saar N, Justo D. Inherited and acquired predispositions for thrombosis in immunocompetent patients with cytomegalovirus-associated thrombosis. European Journal Of Internal Medicine 2009, 21: 2-5. PMID: 20122604, DOI: 10.1016/j.ejim.2009.10.002.Peer-Reviewed Original ResearchConceptsImmunocompetent adultsInherited predispositionImmunocompetent patientsFactor V Leiden mutationV Leiden mutationThrombosis risk factorsImmunocompromised patientsInherited thrombophiliaOral contraceptivesCase seriesCase reportElderly patientsClinical circumstancesThrombosisClinical importanceRisk factorsPatientsPredispositionComplicationsCMVAdultsReportsThrombophiliaContraceptionInfantsC-reactive protein velocity following antibiotics in patients with chronic obstructive pulmonary disease exacerbation and community acquired pneumonia
Justo D, Lachmi S, Saar N, Joffe E, Atzmony L, Mashav N, Henis O, Sade B, Chundadze T, Steinvil A, Paran Y. C-reactive protein velocity following antibiotics in patients with chronic obstructive pulmonary disease exacerbation and community acquired pneumonia. European Journal Of Internal Medicine 2009, 20: 518-521. PMID: 19712857, DOI: 10.1016/j.ejim.2009.03.008.Peer-Reviewed Original ResearchConceptsCAP patientsChronic obstructive pulmonary disease exacerbationsCommunity acquired pneumoniaChronic obstructive pulmonary diseaseInitiation of antibacterial treatmentChronic obstructive pulmonary disease exacerbation patientsCRP levelsExacerbation patientsC-reactive protein velocityAntibacterial treatmentTreated with cephalosporinsChronic obstructive pulmonary disease patientsDays of hospitalizationChest X-rayInternal medicine departmentObstructive pulmonary diseaseProductive coughAntibiotic administrationDisease exacerbationStudy groupPulmonary diseaseCRPPatientsExacerbationMedicine department