2014
Epicutaneous Immunization with TNP-Ig and Zymosan Induces TCRαβ+ CD4+ Contrasuppressor Cells That Reverse Skin-Induced Suppression via IL-17A
Majewska-Szczepanik M, Strzepa A, Marcińska K, Wen L, Szczepanik M. Epicutaneous Immunization with TNP-Ig and Zymosan Induces TCRαβ+ CD4+ Contrasuppressor Cells That Reverse Skin-Induced Suppression via IL-17A. International Archives Of Allergy And Immunology 2014, 164: 122-136. PMID: 24993442, PMCID: PMC4141016, DOI: 10.1159/000363446.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAnimalsAntigensCD4-Positive T-LymphocytesDermatitis, ContactHaptensImmunity, InnateImmunizationImmunoglobulinsImmunosuppression TherapyInterleukin-17Lymph NodesMiceMice, Inbred C57BLMice, Inbred CBAMyeloid Differentiation Factor 88Receptors, Antigen, T-Cell, alpha-betaSkinToll-Like Receptor 2Transforming Growth Factor betaTrinitrobenzenesVaccinationZymosanConceptsSkin-induced suppressionSuppression of CHSContact hypersensitivityEC immunizationEpicutaneous immunizationTNP-IgAdoptive cell transfer experimentsProtein antigensT contrasuppressor cellsT suppressor cellsLymph node cellsCell transfer experimentsCHS responseContrasuppressor cellsIL-17ASuppressor cellsCytokine productionNode cellsImmunogenic antigensPresence of zymosanAntigen E.ImmunizationInnate immunityCD4Gauze patches
2010
Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens
Burton O, Gibbs S, Miller N, Jones F, Wen L, Dunne D, Cooke A, Zaccone P. Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens. European Journal Of Immunology 2010, 40: 2221-2229. PMID: 20480503, DOI: 10.1002/eji.200939998.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, HelminthCD4-Positive T-LymphocytesCells, CulturedFemaleForkhead Transcription FactorsGalectin 3Helminth ProteinsHost-Pathogen InteractionsImmunomodulationLectins, C-TypeMiceMice, Inbred C57BLMice, Inbred NODMice, KnockoutMinor Histocompatibility AntigensReceptors, Cell SurfaceSchistosoma mansoniToll-Like Receptor 2Transforming Growth Factor betaConceptsS. mansoni soluble egg antigenSchistosoma mansoni antigensT cellsFoxp3 expressionImportance of TLR2S. mansoni antigensSurface-bound TGFTLR2 ligand stimulationT cell secretionAccessory cell interactionsNOD miceTh2 responsesEgg antigenImmunomodulatory effectsT lymphocytesAbsence of APCC-type lectinBioactive TGFGalectin-3AntigenTGFTLR2Cell interactionsCellsLigand stimulation
2006
TGF-β signaling is required for the function of insulin-reactive T regulatory cells
Du W, Wong FS, Li MO, Peng J, Qi H, Flavell RA, Sherwin R, Wen L. TGF-β signaling is required for the function of insulin-reactive T regulatory cells. Journal Of Clinical Investigation 2006, 116: 1360-1370. PMID: 16670772, PMCID: PMC1451206, DOI: 10.1172/jci27030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCytokinesGenes, DominantInsulinIslets of LangerhansMiceMice, Inbred NODMice, SCIDMice, TransgenicSignal TransductionT-Lymphocytes, RegulatoryTransforming Growth Factor betaTransgenesConceptsT cellsNOD miceRegulatory cellsDominant negative TGF-beta receptor type IITransgenic miceTCR transgenic T cellsTGF-beta receptor type IIDiabetic NOD miceDiabetogenic spleen cellsDiabetogenic T cellsTCR transgenic miceTransgenic T cellsReceptor type IIBDC2.5 miceAdoptive transferTGF-beta signalingSpleen cellsParacrine mannerGranule antigensAutocrine mannerSuppressive propertiesDiabetesMiceTarget cellsSpontaneous development