2014
Human Slack Potassium Channel Mutations Increase Positive Cooperativity between Individual Channels
Kim GE, Kronengold J, Barcia G, Quraishi IH, Martin HC, Blair E, Taylor JC, Dulac O, Colleaux L, Nabbout R, Kaczmarek LK. Human Slack Potassium Channel Mutations Increase Positive Cooperativity between Individual Channels. Cell Reports 2014, 9: 1661-1672. PMID: 25482562, PMCID: PMC4294418, DOI: 10.1016/j.celrep.2014.11.015.Peer-Reviewed Original Research
2003
Compensatory Anion Currents in Kv1.3 Channel-deficient Thymocytes*
Koni PA, Khanna R, Chang MC, Tang MD, Kaczmarek LK, Schlichter LC, Flavell R. Compensatory Anion Currents in Kv1.3 Channel-deficient Thymocytes*. Journal Of Biological Chemistry 2003, 278: 39443-39451. PMID: 12878608, DOI: 10.1074/jbc.m304879200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBase SequenceCell DivisionChloride ChannelsDNAFemaleGene ExpressionIon TransportKv1.3 Potassium ChannelLymphocyte ActivationMaleMembrane PotentialsMiceMice, Inbred C57BLMice, KnockoutPatch-Clamp TechniquesPotassium ChannelsPotassium Channels, Voltage-GatedRNA, MessengerT-LymphocytesConceptsWild-type cellsKv1.3-/- micePotassium channel subunitsVoltage-gated potassium channelsMouse thymocyte subsetsChloride currentsChannel subunitsAnion currentsT-cell activation/proliferationVoltage-dependent potassium currentsVolume regulationCell proliferationThymocyte apoptosisT cell responsesCell-mediated cytotoxicityObvious defectsCell activation/proliferationImmune system defectsT cell proliferationActivation/proliferationPotassium channelsLymph nodesCompensatory effectLymphocyte typeKv1.3
2001
Localization of two high‐threshold potassium channel subunits in the rat central auditory system
Li W, Kaczmarek L, Perney T. Localization of two high‐threshold potassium channel subunits in the rat central auditory system. The Journal Of Comparative Neurology 2001, 437: 196-218. PMID: 11494252, DOI: 10.1002/cne.1279.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAuditory PathwaysCochlear NucleusFemaleGene ExpressionGeniculate BodiesImmunohistochemistryIn Situ HybridizationInferior ColliculiNeuronsNeuropeptidesOligonucleotide ProbesOlivary NucleusPotassium ChannelsPotassium Channels, Voltage-GatedRatsRats, Sprague-DawleyRNA, MessengerShaw Potassium ChannelsConceptsAuditory neuronsKv3.1 mRNAPotassium channelsMost auditory neuronsBrainstem auditory neuronsRat central auditory systemAction potential thresholdSubpopulation of neuronsCentral auditory systemLateral superior oliveRat auditory systemAuditory systemVoltage-sensitive potassium channelsRapid deactivation kineticsPotassium channel subunitsTrapezoid bodyRat brainstemMedial nucleusVentral nucleusLateral lemniscusTerminal arborizationsSynaptic inputsAuditory nucleiSuperior oliveChannel expression
1998
Heterologous Expression of the Kv3.1 Potassium Channel Eliminates Spike Broadening and the Induction of a Depolarizing Afterpotential in the Peptidergic Bag Cell Neurons
Whim M, Kaczmarek L. Heterologous Expression of the Kv3.1 Potassium Channel Eliminates Spike Broadening and the Induction of a Depolarizing Afterpotential in the Peptidergic Bag Cell Neurons. Journal Of Neuroscience 1998, 18: 9171-9180. PMID: 9801357, PMCID: PMC6792887, DOI: 10.1523/jneurosci.18-22-09171.1998.Peer-Reviewed Original ResearchConceptsBag cell neuronsCell neuronsAction potentialsCalcium entryUse-dependent inactivationExpression of Kv3.1Kv3.1 potassium channelPeptidergic bag cell neuronsControl neuronsSpontaneous firingBrief synaptic stimulationCalcium currentNeuronal excitabilityIntracellular calciumCalcium influxSynaptic stimulationDepolarizing afterpotentialsBAPTA-AMAfterpotentialsNeuronsPotassium channelsClusters of cellsKv3.1InductionPhysiological role
1996
Cloning and Characterization of the Promoter for a Potassium Channel Expressed in High Frequency Firing Neurons (∗)
Gan L, Perney T, Kaczmarek L. Cloning and Characterization of the Promoter for a Potassium Channel Expressed in High Frequency Firing Neurons (∗). Journal Of Biological Chemistry 1996, 271: 5859-5865. PMID: 8621457, DOI: 10.1074/jbc.271.10.5859.Peer-Reviewed Original Research3T3 Cells8-Bromo Cyclic Adenosine MonophosphateAnimalsBase SequenceBinding SitesBucladesineCell DifferentiationChloramphenicol O-AcetyltransferaseCloning, MolecularCyclic AMPDNA PrimersDNA, ComplementaryFibroblastsGene ExpressionGenomic LibraryIonomycinKineticsMiceMolecular Sequence DataNeuronsNeuropeptidesPC12 CellsPlasmidsPodophyllinPodophyllotoxinPotassium ChannelsPotassium Channels, Voltage-GatedPromoter Regions, GeneticRatsRecombinant ProteinsRegulatory Sequences, Nucleic AcidRestriction MappingSequence DeletionShaw Potassium ChannelsTransfection
1995
Elimination of potassium channel expression by antisense oligonucleotides in a pituitary cell line.
Chung S, Saal D, Kaczmarek L. Elimination of potassium channel expression by antisense oligonucleotides in a pituitary cell line. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 5955-5959. PMID: 7597060, PMCID: PMC41620, DOI: 10.1073/pnas.92.13.5955.Peer-Reviewed Original ResearchAnimalsBase SequenceCell MembraneClone CellsDexamethasoneEgtazic AcidGene ExpressionKv1.4 Potassium ChannelKv1.5 Potassium ChannelMembrane PotentialsMolecular Sequence DataOligonucleotides, AntisensePatch-Clamp TechniquesPituitary GlandPotassium Channel BlockersPotassium ChannelsPotassium Channels, Voltage-GatedRatsRNA, MessengerTetraethylammoniumTetraethylammonium CompoundsThionucleotides
1992
Expression of the H-ras oncogene induces potassium conductance and neuron-specific potassium channel mRNAs in the AtT20 cell line
Hemmick L, Perney T, Flamm R, Kaczmarek L, Birnberg N. Expression of the H-ras oncogene induces potassium conductance and neuron-specific potassium channel mRNAs in the AtT20 cell line. Journal Of Neuroscience 1992, 12: 2007-2014. PMID: 1607925, PMCID: PMC6575920, DOI: 10.1523/jneurosci.12-06-02007.1992.Peer-Reviewed Original ResearchConceptsRas-transfected cellsAtT20 cell lineAtT20 cellsEJ-ras oncogeneCell linesPotassium channelsVoltage-dependent potassium channelsRas proteinsPituitary-derived cellsMRNA speciesPlasma membraneSpliced productsPotassium channel mRNASame geneChannel mRNADifferential expressionPotassium currentExcitable cellsVoltage-dependent potassium currentsTwo- to threefold increaseMRNAOncogeneSpeciesExpressionPhenotypeModulation by cAMP of a slowly activating potassium channel expressed in Xenopus oocytes
Blumenthal E, Kaczmarek L. Modulation by cAMP of a slowly activating potassium channel expressed in Xenopus oocytes. Journal Of Neuroscience 1992, 12: 290-296. PMID: 1370322, PMCID: PMC6575684, DOI: 10.1523/jneurosci.12-01-00290.1992.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAmino Acid SequenceAnimalsCell MembraneCyclic AMPFemaleGene ExpressionHumansMembrane PotentialsMembrane ProteinsMolecular Sequence DataMutagenesis, Site-DirectedOocytesPhosphorylationPotassium ChannelsPotassium Channels, Voltage-GatedProgesteroneProtein Kinase InhibitorsProtein KinasesRatsRNATransfectionXenopus laevisConceptsMinK proteinCAMP-dependent protein kinasePotential phosphorylation sitesXenopus oocytesCAMP levelsPhosphorylation sitesProtein kinasePlasma membraneKinase activityChannel proteinsIntracellular cAMP levelsProtein inhibitorProteinKinasePotassium channelsOocytesVoltage-dependent potassium currentsIsK