1991
Dexamethasone increases potassium channel messenger RNA and activity in clonal pituitary cells.
Levitan E, Hemmick L, Birnberg N, Kaczmarek L. Dexamethasone increases potassium channel messenger RNA and activity in clonal pituitary cells. Endocrinology 1991, 5: 1903-8. PMID: 1791837, DOI: 10.1210/mend-5-12-1903.Peer-Reviewed Original ResearchConceptsPituitary cellsChannel expressionClonal rat pituitary cellsChannel messenger RNAIon channel expressionRat pituitary cellsDose-dependent mannerClonal pituitary cellsAnterior pituitaryLong-term effectsRat hypothalamusSimilar pharmacologyGlucocorticoid agonistGlucocorticoid hormonesChannel mRNAGH3 cellsElectrical activitySecretionSteady-state concentrationsTerm effectsPituitaryExcitable cellsHormoneIon channelsMessenger RNA
1990
Estrogen induction of a small, putative K+ channel mRNA in rat uterus
Pragnell M, Snay K, Trimmer J, MacLusky N, Naftolin F, Kaczmarek L, Boyle M. Estrogen induction of a small, putative K+ channel mRNA in rat uterus. Neuron 1990, 4: 807-812. PMID: 2344412, DOI: 10.1016/0896-6273(90)90207-v.Peer-Reviewed Original ResearchConceptsMRNA speciesAmino acid proteinProkaryotic ion channelsDramatic long-term changesMolecular cloningAcid proteinIon channel expressionMammalian sourcesIon channelsXenopus oocytesVoltage-dependent channelsSpeciesStructural motifsCritical roleChannel expressionMRNAChannel mRNAEstrogen inductionLong-term changesInductionCloningProteinMotifRegulationOocytes