Modeling neuro-immune interactions during Zika virus infection
Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, de A. Zanotto PM, Beltrão-Braga PCB, Nizet V, Muotri AR. Modeling neuro-immune interactions during Zika virus infection. Human Molecular Genetics 2017, 27: 41-52. PMID: 29048558, PMCID: PMC5886060, DOI: 10.1093/hmg/ddx382.Peer-Reviewed Original ResearchMeSH KeywordsCell LineHumansInduced Pluripotent Stem CellsMicrogliaModels, BiologicalNeural Stem CellsSofosbuvirZika VirusZika Virus InfectionConceptsNeuro-immune interactionsZika virus infectionVirus infectionSerious neurologic complicationsAntiviral immune responsePro-inflammatory responseSimilar pro-inflammatory responsesNeural precursor cellsNew therapeutic drugsZIKV pathologyHepatitis CNeurologic complicationsMicroglia interactionsHuman microgliaImmune responseViral infectionBrazilian ZIKVMicrogliaInfectionNeural cellsTherapeutic drugsBirth defectsPrecursor cellsDrugsHuman tissuesModeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation
Thomas CA, Tejwani L, Trujillo CA, Negraes PD, Herai RH, Mesci P, Macia A, Crow YJ, Muotri AR. Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation. Cell Stem Cell 2017, 21: 319-331.e8. PMID: 28803918, PMCID: PMC5591075, DOI: 10.1016/j.stem.2017.07.009.Peer-Reviewed Original ResearchMeSH KeywordsAstrocytesAutoimmune DiseasesBase SequenceCell ExtractsChildCytosolDNAExodeoxyribonucleasesHumansInfantInfant, NewbornInflammationInterferonsLong Interspersed Nucleotide ElementsMaleMicrocephalyNervous SystemNeural Stem CellsNeuronsOrganoidsPhenotypePhosphoproteinsStem CellsUp-RegulationConceptsThree-prime repair exonuclease 1Aicardi-Goutières syndromeAutoimmune diseasesSource of neuroinflammationType I interferon secretionSystemic lupus erythematosusRepair exonuclease 1Reverse transcriptase inhibitorStem cellsDisease-relevant phenotypesNeuroinflammatory disordersLupus erythematosusTherapeutic regimensCortical organoidsInflammatory responseInterferon secretionRelated disordersObserved neurotoxicityNeural cellsNeurotoxicityDiseaseNeuronsPluripotent stem cellsDisordersHuman stem cells