1997
Effects of low dose methotrexate on the bone mineral density of patients with rheumatoid arthritis.
Buckley L, Leib E, Cartularo K, Vacek P, Cooper S. Effects of low dose methotrexate on the bone mineral density of patients with rheumatoid arthritis. The Journal Of Rheumatology 1997, 24: 1489-94. PMID: 9263140.Peer-Reviewed Original ResearchConceptsBone mineral densityLow-dose methotrexateRheumatoid arthritisLumbar spineFemoral neckDose methotrexateMineral densityBMD of patientsFemoral neck bone mineral densityNeck bone mineral densitySpine bone mineral densityMeasurement of BMDAntirheumatic drug useVitamin D3 supplementationYears of followupGreater bone lossDMARD useD3 supplementationFollowup visitMTX useBone lossPrednisoneSimilar dosePatientsMethotrexate
1996
Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. A randomized, double-blind, placebo-controlled trial.
Buckley L, Leib E, Cartularo K, Vacek P, Cooper S. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. A randomized, double-blind, placebo-controlled trial. Annals Of Internal Medicine 1996, 125: 961-8. PMID: 8967706, DOI: 10.7326/0003-4819-125-12-199612150-00004.Peer-Reviewed Original ResearchConceptsBone mineral densityLow-dose corticosteroidsPlacebo-controlled trialVitamin D3 supplementationMineral densityRheumatoid arthritisVitamin D3Prednisone therapyLumbar spineD3 supplementationBone lossOutpatient care facilitiesLong-term useCorticosteroid useVertebral fracturesWard's triangleAutoimmune diseasesFemoral neckCorticosteroidsHigh riskSupplemental calciumRational therapyPatientsArthritisTherapy