2024
Nanoparticle-Binding Immunoglobulins Predict Variable Complement Responses in Healthy and Diseased Cohorts
Li Y, Saba L, Scheinman R, Banda N, Holers M, Monte A, Dylla L, Moghimi S, Simberg D. Nanoparticle-Binding Immunoglobulins Predict Variable Complement Responses in Healthy and Diseased Cohorts. ACS Nano 2024, 18: 28649-28658. PMID: 39395006, DOI: 10.1021/acsnano.4c05087.Peer-Reviewed Original ResearchConceptsPegylated liposomal doxorubicinComplement activationPredictive valuePlasma concentrationsC-reactive protein levelsAnti-PEG IgGTriggers proinflammatory responsesAnti-PEG IgMEfficacy of nanomedicinesPoor predictive valueAnti-PEG antibodiesLiposomal doxorubicinIron oxide nanowormsHealthy donorsHigher complement activationAcute infectionInflammatory disease conditionsChronic inflammationProinflammatory responseSystemic administrationComplement cascadeComplement factorsComplement responseIgMProtein levels
2021
Association Between Chronic Inflammatory Diseases and Stroke-Associated Pneumonia – An Epidemiological Study
Dylla L, Herson P, Poisson S, Rice J, Ginde A. Association Between Chronic Inflammatory Diseases and Stroke-Associated Pneumonia – An Epidemiological Study. Journal Of Stroke And Cerebrovascular Diseases 2021, 30: 105605. PMID: 33482567, PMCID: PMC7946738, DOI: 10.1016/j.jstrokecerebrovasdis.2021.105605.Peer-Reviewed Original ResearchConceptsAssociated with reduced in-hospital mortalityRisk of stroke-associated pneumoniaIn-hospital mortalityStroke-associated pneumoniaIn-hospital stroke-associated pneumoniaAssociated with increased risk of strokePost-acute ischemic strokeAssociated with increased riskMultivariate logistic regressionNational Inpatient SampleAssociated with reduced ratesRisk of strokeStroke morbidityRheumatoid arthritisDecreased riskHospital dischargeInpatient SampleLogistic regressionEpidemiological studiesChronic inflammatory diseaseStrokeIschemic strokeMultiple chronic inflammatory diseasesInflammatory bowel diseaseMortality