2023
Provider Perceptions of Oxygenation Strategies for Critically Ill Trauma Patients With and Without Moderate-to-Severe Traumatic Brain Injury
Dylla L, Douin D, Cwik J, Steinwand A, Rice J, Jackson C, Anderson E, Higgins H, Monte A, Ginde A. Provider Perceptions of Oxygenation Strategies for Critically Ill Trauma Patients With and Without Moderate-to-Severe Traumatic Brain Injury. Military Medicine 2023, 188: 166-175. PMID: 37948260, PMCID: PMC11022338, DOI: 10.1093/milmed/usad076.Peer-Reviewed Original ResearchConceptsCritically ill trauma patientsCritical care providersTraumatic brain injuryCare providersTrauma patientsSupplemental oxygenNon-TBI patientsCross-sectional surveyUniversity of Colorado HospitalCase-based scenariosProviders' perceptionsProvider practicesCritically ill TBI patientsProviders' viewsOxygen useProvider typeAdministration of supplemental oxygenTargeted educationAssociated with increased mortalityBrain injuryOxygen saturation thresholdsModerate-to-severeSupplemental oxygen useFisher's exact testCritically ill patientsHyperoxia is associated with a greater risk for mortality in critically ill traumatic brain injury patients than in critically ill trauma patients without brain injury
Douin D, Dylla L, Anderson E, Rice J, Jackson C, Bebarta V, Neumann R, Schauer S, Ginde A. Hyperoxia is associated with a greater risk for mortality in critically ill traumatic brain injury patients than in critically ill trauma patients without brain injury. Science Progress 2023, 106: 00368504231160416. PMID: 36879502, PMCID: PMC10450323, DOI: 10.1177/00368504231160416.Peer-Reviewed Original ResearchConceptsTraumatic brain injury statusTraumatic brain injuryIntensive care unitTraumatic brain injury patientsIn-hospital mortalityCritically ill trauma patientsTrauma patientsState Trauma RegistryNon-TBI patientsRisk of mortalityIntensive care unit daysCritically ill TBI patientsRegional trauma centerRetrospective cohort studyIntensive care unit length of stayLength of stayBrain injuryIntensive care unit lengthTrauma registryInjured adultsSecondary analysisBrain injury patientsCohort studyPatient observationSecondary outcomes
2021
A multicenter cluster randomized, stepped wedge implementation trial for targeted normoxia in critically ill trauma patients: study protocol and statistical analysis plan for the Strategy to Avoid Excessive Oxygen (SAVE-O2) trial
Dylla L, Douin D, Anderson E, Rice J, Jackson C, Bebarta V, Lindsell C, Cheng A, Schauer S, Ginde A. A multicenter cluster randomized, stepped wedge implementation trial for targeted normoxia in critically ill trauma patients: study protocol and statistical analysis plan for the Strategy to Avoid Excessive Oxygen (SAVE-O2) trial. Trials 2021, 22: 784. PMID: 34749762, PMCID: PMC8574946, DOI: 10.1186/s13063-021-05688-6.Peer-Reviewed Original ResearchConceptsCritically ill trauma patientsImplementation trialStatistical analysis planMultimodal interventionTrauma patientsTraining periodStudy protocolTargeted normoxiaVentilator-free daysOne-month training periodGlasgow Outcome ScoreAnalysis planLevel 1 trauma centerCombat casualty careUsual carePre-implementationInjured trauma patientsSupplemental oxygenPost-implementationReduced logistical burdensIntervention phaseOutcome measuresCasualty careMulticenter clusterOutcome scoresAssociation Between Hyperoxia, Supplemental Oxygen, and Mortality in Critically Injured Patients
Douin D, Anderson E, Dylla L, Rice J, Jackson C, Wright F, Bebarta V, Schauer S, Ginde A. Association Between Hyperoxia, Supplemental Oxygen, and Mortality in Critically Injured Patients. Critical Care Explorations 2021, 3: e0418. PMID: 34036272, PMCID: PMC8133168, DOI: 10.1097/cce.0000000000000418.Peer-Reviewed Original ResearchIn-hospital mortalityAdult trauma patientsInjured patientsCohort studyRisk scoreTrauma patientsEmergency department arrivalLevel I trauma centerOutcome of in-hospital mortalityICU admissionMechanism of injuryRisk of mortalityRetrospective cohort studyBlunt trauma mechanismHigh oxygen administrationOxygen administrationSecondary outcomesPrimary outcomeOxygen saturationLevel IIIVentilator-free daysHospital-free daysDays of hospitalizationCritically ill patientsPeriod of hyperoxiaA quasiexperimental study of targeted normoxia in critically ill trauma patients
Dylla L, Anderson E, Douin D, Jackson C, Rice J, Schauer S, Neumann R, Bebarta V, Wright F, Ginde A. A quasiexperimental study of targeted normoxia in critically ill trauma patients. Journal Of Trauma And Acute Care Surgery 2021, 91: s169-s175. PMID: 33797494, PMCID: PMC9709909, DOI: 10.1097/ta.0000000000003177.Peer-Reviewed Original ResearchConceptsCritically ill trauma patientsPostintervention subjectsPostintervention periodTrauma patientsTargeted normoxiaIntervention increased adherenceSupplemental oxygenChronic Health Evaluation II scoreEmergency department arrivalNeurosurgical intensive care unitMilitary trauma patientsIntensive care unitCOnsensus-basedQuasiexperimental studyPostinterventionLevels of FiO2Acute PhysiologyPatient timeII scoreClinical outcomesMm HgTherapeutic/care managementAvoidance of hypoxiaReduce morbidityPrimary outcome