2005
Heart Failure and Cardiac Dysfunction in Diabetes
Young L, Russell R, Chyun D. Heart Failure and Cardiac Dysfunction in Diabetes. Contemporary Cardiology 2005, 555-578. DOI: 10.1385/1-59259-908-7:555.Peer-Reviewed Original ResearchType 2 diabetesHeart failureHigh cardiovascular morbidityPresence of diabetesOral hypoglycemic agentsAge-adjusted riskImpact of diabetesFramingham Heart StudyNondiabetic patientsCardiovascular morbidityNondiabetic menPatient yearsOlder patientsSuch patientsCardiac dysfunctionHypoglycemic agentsHeart StudyClinical problemPatientsDiabetesType 1IncidenceRiskFailureMorbidity
2004
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
Russell RR, Li J, Coven DL, Pypaert M, Zechner C, Palmeri M, Giordano FJ, Mu J, Birnbaum MJ, Young LH. AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. Journal Of Clinical Investigation 2004, 114: 495-503. PMID: 15314686, PMCID: PMC503766, DOI: 10.1172/jci19297.Peer-Reviewed Original ResearchConceptsLow-flow ischemiaGlucose uptakePostischemic reperfusionWT heartsLeft ventricular dPNormal fractional shorteningLV contractile functionPostischemic cardiac dysfunctionInsulin-stimulated glucose uptakeImportant protective roleLong-term inhibitionFatty acid oxidationFractional shorteningHeart failureVentricular dPCardiac consequencesCardiac dysfunctionCaspase-3 activityMyocardial ischemiaContractile functionReperfusionCardiac hypertrophyIschemiaTransgenic miceProtective role