1997
In vitro reduction of endotoxin concentrations with the 5S fragment of immunoglobulin G
Xuan D, Nicolau D, Tessier P, Bow L, Quintiliani R, Nightingale C. In vitro reduction of endotoxin concentrations with the 5S fragment of immunoglobulin G. Antimicrobial Agents And Chemotherapy 1997, 41: 1512-1516. PMID: 9210676, PMCID: PMC163950, DOI: 10.1128/aac.41.7.1512.Peer-Reviewed Original ResearchMeSH KeywordsCefotaximeCephalosporinsColony Count, MicrobialEscherichia coliHumansImmunoglobulin FragmentsImmunoglobulin GKineticsLipopolysaccharidesMicrobial Sensitivity TestsConceptsNegative sepsisAntiendotoxin activityEndotoxin releaseTreatment of sepsisEndotoxin concentrationsTime-kill studiesDose-effect relationRapid bactericidal effectBacterial colony countsColony countsAdjuvant therapyMean reductionSepsisE. coli CFUCFU/Further studiesMajor targetTherapyVitro reductionCefotaximeConcentration curveImmunoglobulin G.Bactericidal effectBactericidal actionBacterial proliferation
1995
Activities of Clarithromycin, Azithromycin, and Ofioxacin in Combination with Liposomal or Unencapsulated Granulocyte-Macrophage Colony-Stimulating Factor against Intramacrophage Mycobacterium avium-Mycobacterium intracellulare
Onyeji C, Nightingale C, Tessier P, Nicolau D, Bow L. Activities of Clarithromycin, Azithromycin, and Ofioxacin in Combination with Liposomal or Unencapsulated Granulocyte-Macrophage Colony-Stimulating Factor against Intramacrophage Mycobacterium avium-Mycobacterium intracellulare. The Journal Of Infectious Diseases 1995, 172: 810-816. PMID: 7658075, DOI: 10.1093/infdis/172.3.810.Peer-Reviewed Original ResearchConceptsMycobacterium avium-Mycobacterium intracellulareGranulocyte-macrophage colony-stimulating factorColony-stimulating factorGM-CSFHuman macrophage infection modelMaximal killing effectTherapeutic peak concentrationsTherapeutic trough concentrationsActivity of clarithromycinEffects of ofloxacinMacrophage infection modelMAI infectionTrough concentrationsSerum troughUseful adjunctClarithromycinAzithromycinInfection modelPeak levelsSignificant augmentationKilling effectPeak concentrationOfloxacinAntimycobacterial activityIntracellulare