1997
Local urokinase delivery with the Channel balloon: Device safety, pharmacokinetics of intracoronary drug delivery, and efficacy of thrombolysis
Mitchel J, Barry J, Bow L, Alberghini T, Abbas S, McKay R. Local urokinase delivery with the Channel balloon: Device safety, pharmacokinetics of intracoronary drug delivery, and efficacy of thrombolysis. Catheterization And Cardiovascular Interventions 1997, 41: 254-260. PMID: 9213023, DOI: 10.1002/(sici)1097-0304(199707)41:3<254::aid-ccd5>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryAnimalsCell DivisionDrug Delivery SystemsEquipment DesignEquipment SafetyFeasibility StudiesFemaleFibrinolytic AgentsIliac ArteryMaleMuscle, Smooth, VascularProliferating Cell Nuclear AntigenSwineThrombolytic TherapyTreatment OutcomeTunica MediaUrokinase-Type Plasminogen ActivatorConceptsLocal urokinase deliveryConventional balloon angioplastyBalloon angioplastyDrug infusionDrug depositionPorcine modelLocal drug delivery catheterLocal deliveryDrug delivery catheterEfficacy of thrombolysisComparative histologic studyCatheter infusionBalloon useVessel traumaCoronary arteryLocal infusionThrombolytic techniquesIntracoronary useHistologic changesBalloon inflationIntramural depositionHistologic studyArtery ratioCoronary vesselsAnesthetized swineLocal delivery of c‐myb antisense oligonucleotides during balloon angioplasty
Azrin M, Mitchel J, Bow L, Pedersen C, Cartun R, Aretz T, Waters D, McKay R. Local delivery of c‐myb antisense oligonucleotides during balloon angioplasty. Catheterization And Cardiovascular Interventions 1997, 41: 232-240. PMID: 9213020, DOI: 10.1002/(sici)1097-0304(199707)41:3<232::aid-ccd2>3.0.co;2-7.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryAnimalsAutoradiographyCell DivisionCoronary DiseaseCoronary VesselsDrug Delivery SystemsFeasibility StudiesFemaleLymphocyte ActivationMiceMicroscopy, FluorescenceMuscle, Smooth, VascularOligonucleotides, AntisenseProliferating Cell Nuclear AntigenProto-Oncogene ProteinsProto-Oncogene Proteins c-mybSwineTrans-ActivatorsConceptsSmooth muscle cell proliferationMuscle cell proliferationIntraluminal deliveryBalloon angioplastyCell proliferationLess cellular proliferationQuantitative immunohistochemical stainingCatheter-based systemC-MybC-myb antisenseCell nuclear antigenArterial injuryPeripheral arteriesLymphocyte proliferationContralateral vesselCarotid arteryImmunohistochemical stainingAngioplastyArterial mediaArterial segmentsNuclear antigenLocal deliveryCellular proliferationArteryProliferationLocalized delivery of heparin to angioplasty sites with iontophoresis
Mitchel J, Azrin M, Fram D, Bow L, McKay R. Localized delivery of heparin to angioplasty sites with iontophoresis. Catheterization And Cardiovascular Interventions 1997, 41: 315-323. PMID: 9213031, DOI: 10.1002/(sici)1097-0304(199707)41:3<315::aid-ccd13>3.0.co;2-m.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAngioplasty, Balloon, CoronaryAnimalsAnticoagulantsAortaCoronary VesselsDose-Response Relationship, DrugDrug Delivery SystemsElastic TissueEquipment DesignHeparinIontophoresisMaleMuscle, Smooth, VascularPlatelet AggregationRatsRats, Sprague-DawleySwineTunica IntimaTunica MediaConceptsPorcine coronary arteriesBalloon injuryPlatelet depositionDrug depositionCoronary arteryIontophoretic catheterHeparin deliveryControl vesselsLocal deliveryContralateral control vesselsIontophoresis of salineEarly platelet depositionFluorescent heparinBalloon inflation pressureInternal elastic laminaIntramural localizationAngioplasty siteBalloon angioplastyCoronary studiesHemodynamic sequelaeIliac vesselsIntramural depositionImmediate drug deliveryPlatelet studiesArtery
1995
Enhanced intracoronary thrombolysis with urokinase using a novel, local drug delivery system. In vitro, in vivo, and clinical studies.
Mitchel J, Fram D, Palme D, Foster R, Hirst J, Azrin M, Bow L, Eldin A, Waters D, McKay R. Enhanced intracoronary thrombolysis with urokinase using a novel, local drug delivery system. In vitro, in vivo, and clinical studies. Circulation 1995, 91: 785-93. PMID: 7828307, DOI: 10.1161/01.cir.91.3.785.Peer-Reviewed Original ResearchConceptsDispatch catheterLocal infusionEnd-hole catheterU urokinaseCatheter infusionIntracoronary thrombusAngioplasty siteUrokinase administrationLocal drug delivery systemIntracoronary thrombolysisUrokinase infusionBalloon angioplastySystemic bolusIntramural depositionNew local drug delivery systemDistal coronary flowLocal urokinase deliveryLocal urokinase infusionThrombus-containing stenosesConventional balloon angioplastyInfusion of urokinaseInfusion of salinePorcine coronary arteriesSystemic fibrinolytic stateCardiac catheterization laboratory