1995
1001–23 Localized Intracoronary Delivery of Urokinase with the Channelled Balloon: Pharmacokinetics of Drug Delivery and Washout
Mitchel J, Fram D, Azrin M, Bow L, Alberghini T, Eldin A, Shwedick M, Waters D, McKay R. 1001–23 Localized Intracoronary Delivery of Urokinase with the Channelled Balloon: Pharmacokinetics of Drug Delivery and Washout. Journal Of The American College Of Cardiology 1995, 25: 347a. DOI: 10.1016/0735-1097(95)92897-e.Peer-Reviewed Original ResearchArtery ratioDrug depositionAngioplasty siteLocal drug delivery catheterLocal drug infusionDrug delivery catheterLocal thrombolysisIntracoronary thrombusCoronary arteryIntracoronary deliveryDrug infusionDrug levelsSimultaneous infusionDelivery catheterVessel dilationAnesthetized pigsWashoutDrug deliveryInfusion pressureBalloonHigh balloonInfusionUrokinasePharmacokineticsUrokinase concentrationEnhanced intracoronary thrombolysis with urokinase using a novel, local drug delivery system. In vitro, in vivo, and clinical studies.
Mitchel J, Fram D, Palme D, Foster R, Hirst J, Azrin M, Bow L, Eldin A, Waters D, McKay R. Enhanced intracoronary thrombolysis with urokinase using a novel, local drug delivery system. In vitro, in vivo, and clinical studies. Circulation 1995, 91: 785-93. PMID: 7828307, DOI: 10.1161/01.cir.91.3.785.Peer-Reviewed Original ResearchConceptsDispatch catheterLocal infusionEnd-hole catheterU urokinaseCatheter infusionIntracoronary thrombusAngioplasty siteUrokinase administrationLocal drug delivery systemIntracoronary thrombolysisUrokinase infusionBalloon angioplastySystemic bolusIntramural depositionNew local drug delivery systemDistal coronary flowLocal urokinase deliveryLocal urokinase infusionThrombus-containing stenosesConventional balloon angioplastyInfusion of urokinaseInfusion of salinePorcine coronary arteriesSystemic fibrinolytic stateCardiac catheterization laboratory
1994
Inhibition of platelet deposition and lysis of intracoronary thrombus during balloon angioplasty using urokinase-coated hydrogel balloons.
Mitchel J, Azrin M, Fram D, Hong M, Wong S, Barry J, Bow L, Curley T, Kiernan F, Waters D. Inhibition of platelet deposition and lysis of intracoronary thrombus during balloon angioplasty using urokinase-coated hydrogel balloons. Circulation 1994, 90: 1979-1988. PMID: 7923688, DOI: 10.1161/01.cir.90.4.1979.Peer-Reviewed Original ResearchConceptsLocal urokinase deliveryVivo balloon angioplastyIntracoronary thrombusBalloon angioplastyPlatelet depositionThrombotic closureDistal embolizationAngioplasty siteAbrupt closureArterial wallHydrogel balloonContralateral control arteriesContralateral control vesselsIntramural drug deliveryVivo studiesConventional balloon angioplastyNew Zealand rabbitsU urokinaseConventional angioplastyBalloon dilatationClinical efficacyReflow phenomenonIliac arteryBlood exposureControl arteries