2022
8 Mechanisms of Damage After Cerebral Hemorrhage
Aronowski J, Sansing L, Xi G, Zhang J. 8 Mechanisms of Damage After Cerebral Hemorrhage. 2022, 92-102.e9. DOI: 10.1016/b978-0-323-69424-7.00008-9.ChaptersIntracerebral hemorrhageBrain damageTreatment of ICHPathogenesis of ICHPre-clinical animal modelsIschemic brain injuryNeurovascular unitCerebral hemorrhageSecondary injuryBrain injuryAnimal modelsTherapeutic interventionsOxidative stressPromising targetHemorrhageInjuryMechanisms of damageNoxious componentsDamageInflammationPathogenesisPathobiologyBlood
2021
Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu
Goods BA, Askenase MH, Markarian E, Beatty HE, Drake RS, Fleming I, DeLong JH, Philip NH, Matouk CC, Awad IA, Zuccarello M, Hanley DF, Love JC, Shalek AK, Sansing LH, Investigators T. Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu. JCI Insight 2021, 6: e145857. PMID: 33749664, PMCID: PMC8026179, DOI: 10.1172/jci.insight.145857.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageAcute brain injurySystemic immune responsesBrain tissue injuryHigh mortality rateLocal cellular responseAcute injuryTreatment optionsIntracerebral eventsBrain injuryCerebral hematomaLeukocyte responseTissue injuryT cellsImmune responseCT scanMortality rateDevastating formImmune dynamicsTherapeutic interventionsLeukocyte dynamicsBrain tissuePatientsInvasive surgeryInjury