2011
Anti-Adrenergic Medications and Edema Development after Intracerebral Hemorrhage
Sansing LH, Messe SR, Cucchiara BL, Lyden PD, Kasner SE. Anti-Adrenergic Medications and Edema Development after Intracerebral Hemorrhage. Neurocritical Care 2011, 14: 395-400. PMID: 21264527, DOI: 10.1007/s12028-010-9498-z.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-2 Receptor AgonistsAdrenergic beta-AntagonistsAgedAntihypertensive AgentsAntioxidantsBenzenesulfonatesBlood PressureBrain EdemaCerebral HemorrhageClonidineCohort StudiesCritical CareDouble-Blind MethodDrug Therapy, CombinationFemaleFree Radical ScavengersGlasgow Coma ScaleHumansMaleMiddle AgedMultivariate AnalysisProspective StudiesTreatment OutcomeConceptsIntracerebral hemorrhageClinical outcomesBlood pressure medication useAcute intracerebral hemorrhageSympathetic nervous systemAdrenergic medicationsAntihypertensive medicationsAntihypertensive treatmentMethodsThe patientsPlacebo armBlood pressureMedication useEdema volumePerihematomal edemaEdema developmentInflammatory responseLess edemaHemorrhage volumeAdrenergic activationMedicationsNervous systemMultivariate analysisEdemaHemorrhagePatients
2009
Prior antiplatelet use does not affect hemorrhage growth or outcome after ICHSYMBOL
Sansing LH, Messe SR, Cucchiara BL, Cohen SN, Lyden PD, Kasner SE. Prior antiplatelet use does not affect hemorrhage growth or outcome after ICHSYMBOL. Neurology 2009, 72: 1397-1402. PMID: 19129506, PMCID: PMC2677505, DOI: 10.1212/01.wnl.0000342709.31341.88.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrainBrain EdemaCausalityCerebral HemorrhageDisease ProgressionDrug-Related Side Effects and Adverse ReactionsFemaleHumansIatrogenic DiseaseImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedOutcome Assessment, Health CarePlatelet Aggregation InhibitorsProspective StudiesTomography, X-Ray ComputedTreatment OutcomeConceptsAntiplatelet medication useAntiplatelet medicationsIntracerebral hemorrhageSpontaneous intracerebral hemorrhageHemorrhage expansionMedication useClinical outcomesICH onsetHemorrhage growthTime of ICHVolume of ICHInitial ICH volumeIntracerebral hemorrhage onsetPrior antiplatelet usePlacebo-controlled trialRecent clinical trialsAssociation of useGrowth of ICHAntiplatelet useEdema growthOral anticoagulationRankin scorePlacebo armCerebral hemorrhageMultivariable analysis