Featured Publications
Development and validation of a prediction model for persistent functional impairment among older ICU survivors
Ferrante LE, Murphy TE, Leo‐Summers L, O'Leary JR, Vander Wyk B, Pisani MA, Gill TM. Development and validation of a prediction model for persistent functional impairment among older ICU survivors. Journal Of The American Geriatrics Society 2022, 71: 188-197. PMID: 36196998, PMCID: PMC9870848, DOI: 10.1111/jgs.18075.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBayes TheoremCritical IllnessFemaleHospitalizationHumansIntensive Care UnitsMalePatient DischargeSurvivorsConceptsPersistent functional impairmentICU hospitalizationFunctional impairmentValidation cohortICU admissionDevelopment cohortOlder Intensive Care Unit SurvivorsIntensive care unit survivorsOlder adultsOlder ICU survivorsMonths of dischargeHigh-risk survivorsCommunity-living participantsGood calibrationHospital lengthICU survivorsCritical illnessMedian agePrior hospitalizationFunctional recoveryNational HealthProbable dementiaHospitalizationHigh riskDepressive symptomsPre–Intensive Care Unit Cognitive Status, Subsequent Disability, and New Nursing Home Admission among Critically Ill Older Adults
Ferrante LE, Murphy TE, Gahbauer EA, Leo-Summers LS, Pisani MA, Gill TM. Pre–Intensive Care Unit Cognitive Status, Subsequent Disability, and New Nursing Home Admission among Critically Ill Older Adults. Annals Of The American Thoracic Society 2018, 15: 622-629. PMID: 29446993, PMCID: PMC5949607, DOI: 10.1513/annalsats.201709-702oc.Peer-Reviewed Original ResearchConceptsIntensive care unit admissionNew nursing home admissionsNursing home admissionCare unit admissionHome admissionCritical illnessUnit admissionModerate impairmentCognitive statusCognitive impairmentOlder adultsMinimal impairmentMultivariable analysisIntensive care unit stayMini-Mental State ExaminationProspective cohort studyIll Older AdultsModerate cognitive impairmentUnit stayCohort studySecondary outcomesSubsequent disabilityPrimary outcomeMean agePrognostic informationFunctional Trajectories Among Older Persons Before and After Critical Illness
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Functional Trajectories Among Older Persons Before and After Critical Illness. JAMA Internal Medicine 2015, 175: 523-529. PMID: 25665067, PMCID: PMC4467795, DOI: 10.1001/jamainternmed.2014.7889.Peer-Reviewed Original ResearchConceptsIntensive care unitLong-term mortalityCritical illnessICU admissionModerate disabilityOlder personsMinimal disabilitySevere disabilityFunctional trajectoriesFunctional declineEarly deathProspective cohort studyDay of admissionPersons 70 yearsGoals of careRisk of deathShort-term mortalityGreater New HavenSignificant functional declineICU lengthCohort studyHospital dischargePremorbid disabilityCare unitMechanical ventilationIn-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcomeSocial Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization
Jain S, Murphy T, Falvey J, Leo-Summers L, O’Leary J, Zang E, Gill T, Krumholz H, Ferrante L. Social Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization. JAMA Network Open 2024, 7: e2410713. PMID: 38728030, PMCID: PMC11087837, DOI: 10.1001/jamanetworkopen.2024.10713.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthOccupational therapyPhysical therapyOlder adultsRural residentsIntensive care unit hospitalizationRehabilitation deliveryIntensive care unitSocial determinantsSocioeconomic disadvantageNational Health and Aging Trends StudyDelivery of physical therapyIllness hospitalizationFactors associated with lower oddsDelivery of rehabilitationIn-hospital rehabilitationMitigate functional declineMedicaid eligibilityBurden of disabilityHigh school educationDual MedicareTrends StudyMedicare claimsLength of stay
2024
Associations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults
Lee S, McAvay G, Geda M, Chattopadhyay S, Acampora D, Araujo K, Charpentier P, Gill T, Hajduk A, Cohen A, Ferrante L. Associations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults. The Journals Of Gerontology Series A 2024, 79: glae092. PMID: 38558166, PMCID: PMC11059296, DOI: 10.1093/gerona/glae092.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCOVID-19FemaleHospitalizationHumansMaleMental HealthMiddle AgedProspective StudiesSARS-CoV-2Social SupportConceptsLow social supportMental health symptomsSocial supportSymptom burdenHealth symptomsFollow-up assessmentCOVID-19 hospitalizationMedical Outcomes Study Social Support SurveyPhysical symptomsAssociation of social supportEdmonton Symptom Assessment SystemPatient Health Questionnaire-4Burden of physical symptomsMental health symptom burdenModified Edmonton Symptom Assessment SystemSocial Support SurveyParticipants' mean ageAssociated with higher burdenSupport SurveyOlder survivorsSymptom managementOlder AdultsMental healthHispanic ethnicityLongitudinal associations
2022
Rationale, Design, and Characteristics of the VALIANT (COVID‐19 in Older Adults: A Longitudinal Assessment) Cohort
Cohen A, McAvay G, Geda M, Chattopadhyay S, Lee S, Acampora D, Araujo K, Charpentier P, Gill T, Hajduk A, Ferrante L. Rationale, Design, and Characteristics of the VALIANT (COVID‐19 in Older Adults: A Longitudinal Assessment) Cohort. Journal Of The American Geriatrics Society 2022, 71: 832-844. PMID: 36544250, PMCID: PMC9877652, DOI: 10.1111/jgs.18146.Peer-Reviewed Original ResearchMeSH KeywordsAftercareAgedCOVID-19FemaleHospitalizationHumansMalePatient DischargeProspective StudiesConceptsPatient-centered outcomesCOVID-19 hospitalizationCognitive impairmentPhysical functionOlder COVID-19 survivorsCOVID-19-related symptomsCOVID-19Older adultsIntensive care unitCOVID-19 survivorsPersistent cognitive impairmentSix-month followMost older adultsThird of participantsElectronic health recordsStepdown unitAcute illnessBurdensome symptomsCare unitSupplemental oxygenMedian lengthProspective studyMean ageBlack raceBaseline interview
2021
Functional Effects of Intervening Illnesses and Injuries After Critical Illness in Older Persons
Gill TM, Han L, Gahbauer EA, Leo-Summers L, Murphy TE, Ferrante LE. Functional Effects of Intervening Illnesses and Injuries After Critical Illness in Older Persons. Critical Care Medicine 2021, 49: 956-966. PMID: 33497167, PMCID: PMC8140984, DOI: 10.1097/ccm.0000000000004829.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overBody Mass IndexCognitionCritical IllnessEmergency Service, HospitalFemaleFrail ElderlyHealth StatusHospitalizationHumansLongitudinal StudiesMaleMental HealthPhysical Functional PerformanceProspective StudiesSelf EfficacySocioeconomic FactorsWounds and InjuriesConceptsEmergency department visitsCritical illnessDepartment visitsICU admissionFunctional outcomeFunctional statusFunctional declineOlder personsAdjusted hazard ratioAdverse functional outcomesCommunity-living personsTraditional risk factorsCommunity-living participantsCorresponding odds ratiosFunctional effectsProspective longitudinal studyHazard ratioRisk factorsOdds ratioHospitalizationPremorbid functionInjuryIllnessRestricted activityAnalytic sample
2020
Home Health Rehabilitation Utilization Among Medicare Beneficiaries Following Critical Illness
Falvey JR, Murphy TE, Gill TM, Stevens‐Lapsley J, Ferrante LE. Home Health Rehabilitation Utilization Among Medicare Beneficiaries Following Critical Illness. Journal Of The American Geriatrics Society 2020, 68: 1512-1519. PMID: 32187664, PMCID: PMC7712590, DOI: 10.1111/jgs.16412.Peer-Reviewed Original ResearchConceptsRehabilitation visitsCritical illnessMedicare beneficiariesICU survivorsHome healthPost-acute care facilitiesIntensive care unit survivorsDays of dischargeHigher baseline disabilityAssessment Information SetPost-hospitalization periodRural settingsHome-based rehabilitationHH careHH servicesHH settingHospice transferLeast disabilityMore comorbiditiesBaseline disabilityICU stayElixhauser scoreHighest tertileRehabilitation utilizationDischarge planning
2018
The Competing Risk of Death in Longitudinal Geriatric Outcomes
Murphy TE, Gill TM, Leo‐Summers L, Gahbauer EA, Pisani MA, Ferrante LE. The Competing Risk of Death in Longitudinal Geriatric Outcomes. Journal Of The American Geriatrics Society 2018, 67: 357-362. PMID: 30537050, PMCID: PMC6367003, DOI: 10.1111/jgs.15697.Peer-Reviewed Original ResearchConceptsFall-related hospitalizationsRisk of deathProspective cohort studyPersons 70 yearsLong-term followPrecipitating Events ProjectCommunity-based dataLongitudinal studyGeriatric outcomesCohort studyFried phenotypeFunctional recoveryTotal disabilityOutcome eventsDaily livingClinical scenariosSecondary analysisOlder personsVision impairmentDeathBasic activitiesOutcomesDisabilityDecedentsRisk