Featured Publications
Development and validation of a prediction model for persistent functional impairment among older ICU survivors
Ferrante LE, Murphy TE, Leo‐Summers L, O'Leary JR, Vander Wyk B, Pisani MA, Gill TM. Development and validation of a prediction model for persistent functional impairment among older ICU survivors. Journal Of The American Geriatrics Society 2022, 71: 188-197. PMID: 36196998, PMCID: PMC9870848, DOI: 10.1111/jgs.18075.Peer-Reviewed Original ResearchConceptsPersistent functional impairmentICU hospitalizationFunctional impairmentValidation cohortICU admissionDevelopment cohortOlder Intensive Care Unit SurvivorsIntensive care unit survivorsOlder adultsOlder ICU survivorsMonths of dischargeHigh-risk survivorsCommunity-living participantsGood calibrationHospital lengthICU survivorsCritical illnessMedian agePrior hospitalizationFunctional recoveryNational HealthProbable dementiaHospitalizationHigh riskDepressive symptomsAssociation Between Socioeconomic Disadvantage and Decline in Function, Cognition, and Mental Health After Critical Illness Among Older Adults : A Cohort Study.
Jain S, Murphy TE, O'Leary JR, Leo-Summers L, Ferrante LE. Association Between Socioeconomic Disadvantage and Decline in Function, Cognition, and Mental Health After Critical Illness Among Older Adults : A Cohort Study. Annals Of Internal Medicine 2022, 175: 644-655. PMID: 35254879, PMCID: PMC9316386, DOI: 10.7326/m21-3086.Peer-Reviewed Original ResearchConceptsICU hospitalizationIntensive care unitMental healthCohort studyCritical illnessDual eligibilityOlder adultsProbable dementiaSocioeconomic disadvantageOlder personsGreater riskCommunity-dwelling older adultsLongitudinal cohort studySymptoms of depressionAging Trends StudyOutcome of functionMental health outcomesClinical characteristicsLow-income seniorsCare unitNational HealthRetrospective analysisHospitalizationOlder survivorsDaily livingAssociation of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness
Falvey JR, Cohen AB, O’Leary J, Leo-Summers L, Murphy TE, Ferrante LE. Association of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness. JAMA Internal Medicine 2021, 181: 1433-1439. PMID: 34491282, PMCID: PMC8424527, DOI: 10.1001/jamainternmed.2021.5022.Peer-Reviewed Original ResearchConceptsCritical illnessICU hospitalizationSocial isolation scoresOlder adultsICU admissionCohort studyPrimary outcomeDisability burdenSocial isolationCommunity-dwelling older adultsGreater disability burdenIsolation scoresPost-ICU disabilityObservational cohort studyAging Trends StudyICU stayMortality cohortHospital dischargeSecondary outcomesHospital admissionMedian ageIllness severityAdverse outcomesNational HealthHospitalization dataNeighborhood Socioeconomic Disadvantage and Disability After Critical Illness*
Falvey JR, Murphy TE, Leo-Summers L, Gill TM, Ferrante LE. Neighborhood Socioeconomic Disadvantage and Disability After Critical Illness*. Critical Care Medicine 2021, 50: 733-741. PMID: 34636807, PMCID: PMC9001742, DOI: 10.1097/ccm.0000000000005364.Peer-Reviewed Original ResearchConceptsNeighborhood socioeconomic disadvantageDisability burdenHigher disability burdenCritical illnessSocioeconomic disadvantageOlder adultsCritical illness survivorsLongitudinal cohort studyArea Deprivation IndexDisadvantaged neighborhoodsNon-Hispanic whitesDifferent functional tasksICU admissionICU dischargeICU survivorsCohort studyDischarge destinationHospital dischargeFunctional recoveryNeighborhood disadvantageAdjusted modelCare servicesSecondary analysisSecondary objectiveIllnessSociety of Critical Care Medicine's International Consensus Conference on Prediction and Identification of Long-Term Impairments After Critical Illness.
Mikkelsen ME, Still M, Anderson BJ, Bienvenu OJ, Brodsky MB, Brummel N, Butcher B, Clay AS, Felt H, Ferrante LE, Haines KJ, Harhay MO, Hope AA, Hopkins RO, Hosey M, Hough CTL, Jackson JC, Johnson A, Khan B, Lone NI, MacTavish P, McPeake J, Montgomery-Yates A, Needham DM, Netzer G, Schorr C, Skidmore B, Stollings JL, Umberger R, Andrews A, Iwashyna TJ, Sevin CM. Society of Critical Care Medicine's International Consensus Conference on Prediction and Identification of Long-Term Impairments After Critical Illness. Critical Care Medicine 2020, 48: 1670-1679. PMID: 32947467, DOI: 10.1097/ccm.0000000000004586.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCritical illnessLong-term impairmentInternational Consensus ConferenceHospital dischargeSerial assessmentConsensus conferenceFunctional abilityCritical Care Medicine Consensus ConferenceSystematic reviewPost-intensive care syndromeCare coordination strategiesMontreal Cognitive Assessment (MoCA) testHigh-risk patientsHealth-related qualityMental health functionCognitive Assessment testOriginal systematic reviewAssessment of survivorsEvent Scale-RevisedICU admissionEuroQol-5DCochrane LibraryHospital AnxietyDepression ScaleLife measuresThe Association of Frailty With Post-ICU Disability, Nursing Home Admission, and Mortality A Longitudinal Study
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. The Association of Frailty With Post-ICU Disability, Nursing Home Admission, and Mortality A Longitudinal Study. CHEST Journal 2018, 153: 1378-1386. PMID: 29559308, PMCID: PMC6026287, DOI: 10.1016/j.chest.2018.03.007.Peer-Reviewed Original ResearchConceptsNursing home admissionPost-ICU disabilityHome admissionCritical illnessFrailty statusGreater disabilityNew nursing home admissionsAssociation of frailtyLikelihood of deathOne-point increaseICU admissionICU survivorsICU outcomesMean agePrognostic informationPrefrailtyFried indexAdmissionFrailtyOlder personsParent cohortAnalytic sampleFunctional activityNonfrailtyDisabilityPre–Intensive Care Unit Cognitive Status, Subsequent Disability, and New Nursing Home Admission among Critically Ill Older Adults
Ferrante LE, Murphy TE, Gahbauer EA, Leo-Summers LS, Pisani MA, Gill TM. Pre–Intensive Care Unit Cognitive Status, Subsequent Disability, and New Nursing Home Admission among Critically Ill Older Adults. Annals Of The American Thoracic Society 2018, 15: 622-629. PMID: 29446993, PMCID: PMC5949607, DOI: 10.1513/annalsats.201709-702oc.Peer-Reviewed Original ResearchConceptsIntensive care unit admissionNew nursing home admissionsNursing home admissionCare unit admissionHome admissionCritical illnessUnit admissionModerate impairmentCognitive statusCognitive impairmentOlder adultsMinimal impairmentMultivariable analysisIntensive care unit stayMini-Mental State ExaminationProspective cohort studyIll Older AdultsModerate cognitive impairmentUnit stayCohort studySecondary outcomesSubsequent disabilityPrimary outcomeMean agePrognostic informationFactors Associated with Functional Recovery among Older Intensive Care Unit Survivors
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Factors Associated with Functional Recovery among Older Intensive Care Unit Survivors. American Journal Of Respiratory And Critical Care Medicine 2016, 194: 299-307. PMID: 26840348, PMCID: PMC4970594, DOI: 10.1164/rccm.201506-1256oc.Peer-Reviewed Original ResearchConceptsHigher body mass indexOlder ICU survivorsIntensive care unitBody mass indexFunctional recoveryICU survivorsICU admissionMass indexOlder Intensive Care Unit SurvivorsIntensive care unit survivorsOlder adultsPoor functional recoveryCritical illnessIndependent predictorsCare unitMultivariable analysisFunctional outcomePremorbid functionPotential predictorsVision impairmentAdmissionSurvivorsAnalytic sampleFunctional activityMonthsFunctional Trajectories Among Older Persons Before and After Critical Illness
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Functional Trajectories Among Older Persons Before and After Critical Illness. JAMA Internal Medicine 2015, 175: 523-529. PMID: 25665067, PMCID: PMC4467795, DOI: 10.1001/jamainternmed.2014.7889.Peer-Reviewed Original ResearchConceptsIntensive care unitLong-term mortalityCritical illnessICU admissionModerate disabilityOlder personsMinimal disabilitySevere disabilityFunctional trajectoriesFunctional declineEarly deathProspective cohort studyDay of admissionPersons 70 yearsGoals of careRisk of deathShort-term mortalityGreater New HavenSignificant functional declineICU lengthCohort studyHospital dischargePremorbid disabilityCare unitMechanical ventilationFeasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study
Stevenson J, Murphy T, Tessier-Sherman B, Pisani M, Gill T, Ferrante L. Feasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study. CHEST Critical Care 2024, 2: 100093. DOI: 10.1016/j.chstcc.2024.100093.Peer-Reviewed Original ResearchRisk prediction toolsICU survivorsIn-hospital administrationOlder adultsFunctional impairmentPilot studyIn-hospital mobilityOlder ICU survivorsDevelopment of risk prediction modelsHospital-related factorsIn-hospital factorsPresence of deliriumRisk prediction modelModel discriminationPersistent functional impairmentStatistical significanceHospital settingStudy designFeasibility thresholdDaily activitiesIncreased riskInternational Consensus ConferenceConsensus conferenceSurvivorsCritical illness
2024
Association Between Restricting Symptoms and Disability After Critical Illness Among Older Adults.
Jain S, Han L, Gahbauer E, Leo-Summers L, Feder S, Ferrante L, Gill T. Association Between Restricting Symptoms and Disability After Critical Illness Among Older Adults. Critical Care Medicine 2024 PMID: 39298623, DOI: 10.1097/ccm.0000000000006427.Peer-Reviewed Original ResearchActivities of daily livingAssociated with increased disabilityDaily livingOlder adultsRestricting symptomsInstrumental activities of daily livingCommunity-living older adultsICU hospitalizationMultivariable Poisson regression modelsCommunity-living adultsOlder ICU survivorsAge of participantsPoisson regression modelsSurvive critical illnessCritical illnessQuality of lifeInstrumental activitiesICU survivorsProspective longitudinal studyLength of stayPost-ICUIncreased disabilityMonthly interviewsICU length of stayPre-ICU
2023
Changes in Restricting Symptoms after Critical Illness among Community-Living Older Adults.
Jain S, Han L, Gahbauer E, Leo-Summers L, Feder S, Ferrante L, Gill T. Changes in Restricting Symptoms after Critical Illness among Community-Living Older Adults. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 1206-1215. PMID: 37769149, PMCID: PMC10868351, DOI: 10.1164/rccm.202304-0693oc.Peer-Reviewed Original ResearchConceptsNeighborhood-level socioeconomic disadvantageCritical illnessIntensive care unitHospital dischargeCommunity-living older adultsOlder adultsOlder ICU survivorsPost-ICU careSocioeconomic disadvantageProspective longitudinal studyQuality of lifeICU admissionICU survivorsCare unitFunctional recoverySymptom managementMultiple symptomsThird monthThree monthsSymptomsIllnessRestricted activityVulnerable subgroupsFirst monthMonthsBetter but Not Well: Disability, Frailty, and Cognitive Impairment One Year after COVID-19 Critical Illness
Auriemma C, Ferrante L. Better but Not Well: Disability, Frailty, and Cognitive Impairment One Year after COVID-19 Critical Illness. Annals Of The American Thoracic Society 2023, 20: 202-203. PMID: 36723478, PMCID: PMC9989858, DOI: 10.1513/annalsats.202211-929ed.Commentaries, Editorials and Letters
2022
Clin‐STAR corner: Recent practice‐changing studies at the interface of pulmonary and critical care medicine and geriatrics
Jain S, Witt L, Ferrante L. Clin‐STAR corner: Recent practice‐changing studies at the interface of pulmonary and critical care medicine and geriatrics. Journal Of The American Geriatrics Society 2022, 71: 705-710. PMID: 36536494, PMCID: PMC10023292, DOI: 10.1111/jgs.18196.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCritical care medicineCritical illnessPulmonary diseaseLung diseaseCare medicineRecent practice-changing clinical trialsChronic obstructive pulmonary diseaseOlder adultsAcute respiratory failurePractice-changing clinical trialsChronic lung diseaseChronic pulmonary diseaseObstructive pulmonary diseaseInterstitial lung diseasePractice-changing studiesGreater side effectsRespiratory failureAdverse outcomesClinical trialsObservational studySide effectsDiseaseIllnessAdultsMedicineLong-term recovery after critical illness in older adults
Kaushik R, Ferrante LE. Long-term recovery after critical illness in older adults. Current Opinion In Critical Care 2022, 28: 572-580. PMID: 35950731, PMCID: PMC9458622, DOI: 10.1097/mcc.0000000000000981.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOlder ICU patientsPost-ICU recoveryCritical illnessGeriatric syndromesLong-term recoveryOlder adultsICU patientsRisk factorsIncidence of frailtyOlder ICU survivorsTransitional care programLong-term outcomesContinuum of careSocial isolationRecent epidemiologic workSocial risk factorsICU survivorsRecent literature pertainingUnique needsRecent longitudinal studiesNew disabilityWorse outcomesFunctional declineCare programSyndrome
2021
Functional Effects of Intervening Illnesses and Injuries After Critical Illness in Older Persons
Gill TM, Han L, Gahbauer EA, Leo-Summers L, Murphy TE, Ferrante LE. Functional Effects of Intervening Illnesses and Injuries After Critical Illness in Older Persons. Critical Care Medicine 2021, 49: 956-966. PMID: 33497167, PMCID: PMC8140984, DOI: 10.1097/ccm.0000000000004829.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overBody Mass IndexCognitionCritical IllnessEmergency Service, HospitalFemaleFrail ElderlyHealth StatusHospitalizationHumansLongitudinal StudiesMaleMental HealthPhysical Functional PerformanceProspective StudiesSelf EfficacySocioeconomic FactorsWounds and InjuriesConceptsEmergency department visitsCritical illnessDepartment visitsICU admissionFunctional outcomeFunctional statusFunctional declineOlder personsAdjusted hazard ratioAdverse functional outcomesCommunity-living personsTraditional risk factorsCommunity-living participantsCorresponding odds ratiosFunctional effectsProspective longitudinal studyHazard ratioRisk factorsOdds ratioHospitalizationPremorbid functionInjuryIllnessRestricted activityAnalytic sample
2020
Prediction Models for Physical, Cognitive, and Mental Health Impairments After Critical Illness: A Systematic Review and Critical Appraisal
Haines KJ, Hibbert E, McPeake J, Anderson BJ, Bienvenu OJ, Andrews A, Brummel NE, Ferrante LE, Hopkins RO, Hough CL, Jackson J, Mikkelsen ME, Leggett N, Montgomery-Yates A, Needham DM, Sevin CM, Skidmore B, Still M, van Smeden M, Collins GS, Harhay MO. Prediction Models for Physical, Cognitive, and Mental Health Impairments After Critical Illness: A Systematic Review and Critical Appraisal. Critical Care Medicine 2020, 48: 1871-1880. PMID: 33060502, PMCID: PMC7673641, DOI: 10.1097/ccm.0000000000004659.Peer-Reviewed Original ResearchConceptsCritical illnessMental health impairmentSystematic reviewHealth impairmentBias assessment toolRisk of biasStudy eligibility criteriaPrediction model RiskComposite outcomeAdult patientsTrial enrollmentCochrane LibraryPatient recoveryIndependent reviewersHigh riskEligibility criteriaOutcome measurementsStandardized outcomesAdult survivorsStudy characteristicsIllnessStudy designSystematic searchImpairmentCandidate predictorsHome Health Rehabilitation Utilization Among Medicare Beneficiaries Following Critical Illness
Falvey JR, Murphy TE, Gill TM, Stevens‐Lapsley J, Ferrante LE. Home Health Rehabilitation Utilization Among Medicare Beneficiaries Following Critical Illness. Journal Of The American Geriatrics Society 2020, 68: 1512-1519. PMID: 32187664, PMCID: PMC7712590, DOI: 10.1111/jgs.16412.Peer-Reviewed Original ResearchConceptsRehabilitation visitsCritical illnessMedicare beneficiariesICU survivorsHome healthPost-acute care facilitiesIntensive care unit survivorsDays of dischargeHigher baseline disabilityAssessment Information SetPost-hospitalization periodRural settingsHome-based rehabilitationHH careHH servicesHH settingHospice transferLeast disabilityMore comorbiditiesBaseline disabilityICU stayElixhauser scoreHighest tertileRehabilitation utilizationDischarge planning
2019
Factors Associated With Discharge Home Among Medical ICU Patients in an Early Mobilization Program
Kim RY, Murphy TE, Doyle M, Pulaski C, Singh M, Tsang S, Wicker D, Pisani MA, Connors GR, Ferrante LE. Factors Associated With Discharge Home Among Medical ICU Patients in an Early Mobilization Program. Critical Care Explorations 2019, 1: e0060. PMID: 32166241, PMCID: PMC7063960, DOI: 10.1097/cce.0000000000000060.Peer-Reviewed Original ResearchMedical ICU patientsEarly mobilization programICU patientsDischarge homeMobilization programMedical ICUChronic Health Evaluation II scoreGreater hospital lengthMean Acute PhysiologyRetrospective cohort studyMultivariable logistic regressionAcute PhysiologyICU stayAmbulatory statusHospital lengthICU admissionICU hospitalizationII scoreAnalytic cohortCohort studyCritical illnessEarly mobilizationWard transferMultivariable analysisMean agePatient-Centered Outcomes in Critical Illness: Will My Patient Be Functionally and Cognitively Intact?
Geer JH, Qi W, Ferrante LE. Patient-Centered Outcomes in Critical Illness: Will My Patient Be Functionally and Cognitively Intact? Seminars In Respiratory And Critical Care Medicine 2019, 40: 638-647. PMID: 31826264, DOI: 10.1055/s-0039-1698379.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements