2024
Artificial intelligence applied to electrocardiographic images for the risk stratification of cancer therapeutics-related cardiac dysfunction
Oikonomou E, Sangha V, Dhingra L, Aminorroaya A, Coppi A, Krumholz H, Baldassarre L, Khera R. Artificial intelligence applied to electrocardiographic images for the risk stratification of cancer therapeutics-related cardiac dysfunction. European Heart Journal 2024, 45: ehae666.3190. DOI: 10.1093/eurheartj/ehae666.3190.Peer-Reviewed Original ResearchCancer therapeutics-related cardiac dysfunctionImmune checkpoint inhibitorsGlobal longitudinal strainLeft ventricular systolic dysfunctionNon-Hodgkin's lymphomaCardiac dysfunctionAI-ECGNegative control analysesAssociated with higher incidenceVentricular systolic dysfunctionCohort of patientsRisk stratification strategiesCheckpoint inhibitorsTrastuzumab exposureSystolic dysfunctionRisk stratificationBreast cancerRisk biomarkersSecondary outcomesLongitudinal strainStratification strategiesTrastuzumabPatientsHigher incidenceAnthracyclinesRetraction notice to Gedatolisib Associated Acute Myocarditis in a Patient With Breast Adenocarcinoma J Am Coll Cardiol. 2024;83(13 Suppl):3575.
Shen M, Khattab M, Akintoye E, Baldassarre L, Kwan J. Retraction notice to Gedatolisib Associated Acute Myocarditis in a Patient With Breast Adenocarcinoma J Am Coll Cardiol. 2024;83(13 Suppl):3575. Journal Of The American College Of Cardiology 2024, 84: 1683. DOI: 10.1016/j.jacc.2024.09.017.Peer-Reviewed Original ResearchKiosk 5R-TA-04 Comprehensive Characterization of Cardiac, Skeletal and Diaphragmatic Myotoxicity Using CMR in Patients with Immune Checkpoint Inhibitor Therapy and Relation to Outcomes
Charpentier E, boussouar S, Bretagne M, Bouazizi K, Kachenoura N, Nguyen L, Pasi N, Edhery S, allenbach Y, Similowski T, Kerneis M, Baldassarre L, Salem J, Redheuil A. Kiosk 5R-TA-04 Comprehensive Characterization of Cardiac, Skeletal and Diaphragmatic Myotoxicity Using CMR in Patients with Immune Checkpoint Inhibitor Therapy and Relation to Outcomes. Journal Of Cardiovascular Magnetic Resonance 2024, 26: 100680. DOI: 10.1016/j.jocmr.2024.100680.Peer-Reviewed Original Research
2023
Multimodality Evaluation of Spontaneous Coronary Artery Dissection in a Patient With Connective Tissue Disease: A Case Report
Shah T, Shah N, Baldassarre L, Freed L, Mojibian H, Shah S. Multimodality Evaluation of Spontaneous Coronary Artery Dissection in a Patient With Connective Tissue Disease: A Case Report. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101125. PMID: 39129904, PMCID: PMC11308843, DOI: 10.1016/j.jscai.2023.101125.Peer-Reviewed Case Reports and Technical NotesMyocardial Injury on CMR in Patients With COVID-19 and Suspected Cardiac Involvement
Vidula M, Rajewska-Tabor J, Cao J, Kang Y, Craft J, Mei W, Chandrasekaran P, Clark D, Poenar A, Gorecka M, Malahfji M, Cowan E, Kwan J, Reinhardt S, Al-Tabatabaee S, Doeblin P, Villa A, Karagodin I, Alvi N, Christia P, Spetko N, Cassar M, Park C, Nambiar L, Turgut A, Azad M, Lambers M, Wong T, Salerno M, Kim J, Elliott M, Raman B, Neubauer S, Tsao C, LaRocca G, Patel A, Chiribiri A, Kelle S, Baldassarre L, Shah D, Hughes S, Tong M, Pyda M, Simonetti O, Plein S, Han Y. Myocardial Injury on CMR in Patients With COVID-19 and Suspected Cardiac Involvement. JACC Cardiovascular Imaging 2023, 16: 609-624. PMID: 36752429, PMCID: PMC9833283, DOI: 10.1016/j.jcmg.2022.10.021.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonanceNatriuretic peptide elevationMyocardial injuryIschemic patternTroponin elevationCardiac involvementChest discomfortInjury patternsCOVID-19Cardiac biomarker elevationCOVID-19 infectionAcute myocarditisAcute ischemicBiomarker elevationCardiac symptomsClinical suspicionCoronary diseaseMulticenter cohortAbnormal electrocardiogramMulticenter studyRetrospective studyECG abnormalitiesUnivariate analysisPatientsMultivariate analysis
2022
Advances in Multimodality Imaging in Cardio-Oncology JACC State-of-the-Art Review
Baldassarre LA, Ganatra S, Lopez-Mattei J, Yang EH, Zaha VG, Wong TC, Ayoub C, DeCara JM, Dent S, Deswal A, Ghosh AK, Henry M, Khemka A, Leja M, Rudski L, Villarraga HR, Liu JE, Barac A, Scherrer-Crosbie M, Councils A. Advances in Multimodality Imaging in Cardio-Oncology JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2022, 80: 1560-1578. PMID: 36229093, DOI: 10.1016/j.jacc.2022.08.743.Peer-Reviewed Original ResearchConceptsCardio-oncology patientsAdverse cardiovascular effectsLong-term survivorsPopulation of patientsCardiovascular complicationsPregnant patientsCardiovascular effectsCardiac massAntineoplastic therapyJACC StateVascular toxicityPatientsMultimodality imagingCancerImagingNumerous advancesReviewComplicationsAtherosclerosisTherapyPopulationDiseaseSurvivorsDiagnosisCardiac computed tomographic imaging in cardio-oncology: An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT). Endorsed by the International Cardio-Oncology Society (ICOS)
Lopez-Mattei J, Yang EH, Baldassarre LA, Agha A, Blankstein R, Choi AD, Chen MY, Meyersohn N, Daly R, Slim A, Rochitte C, Blaha M, Whelton S, Dzaye O, Dent S, Milgrom S, Ky B, Iliescu C, Mamas MA, Ferencik M. Cardiac computed tomographic imaging in cardio-oncology: An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT). Endorsed by the International Cardio-Oncology Society (ICOS). Journal Of Cardiovascular Computed Tomography 2022, 17: 66-83. PMID: 36216699, DOI: 10.1016/j.jcct.2022.09.002.Peer-Reviewed Original ResearchConceptsCardio-OncologyCardiac CTCardio-oncology patientsExpert consensus statementCardiovascular Computed TomographyExpert consensus documentConsensus statementComputed tomographyCurrent evidenceConsensus documentMultimodality imagingPractice recommendationsRadiation oncologyCCT applicationMultidisciplinary collaborationOncologyTomographic imagingImagingPatientsLimited guidanceCardiacCliniciansCardiologyCTCareCoronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry
Nowatzke J, Guedeney P, Palaskas N, Lehmann L, Ederhy S, Zhu H, Cautela J, Francis S, Courand PY, Deswal A, Ewer SM, Aras M, Arangalage D, Ghafourian K, Fenioux C, Finke D, Peretto G, Zaha V, Zadok O, Tajiri K, Akhter N, Levenson J, Baldassarre L, Power J, Huang S, Collet JP, Moslehi J, Salem JE, contributors I, Aghel N, Alexandre J, Aonuma K, Asnani A, Behling J, Bilen M, Bottinor W, Cariou E, Chahine J, Chan W, Chauhan A, Cohen M, Crusz S, Fernando S, Florido R, Frigeri M, Fukushima S, Gaughan E, Geisler B, Gilstrap L, Grohe C, Guha A, Habib M, Haegler-Laube E, Haydon A, Hayek S, Hughes A, Imai R, Katsume Y, Kimura H, Lin L, Lenneman C, Leong D, Makker V, Martinez-Calle N, Moey M, Mohri M, Morimoto R, Moritoki Y, Narezkina A, Nicol M, Nooka A, Orimoloye O, Patel M, Perl M, Piriou N, Raikhelkar J, Raza Y, Rao A, Reddy S, Seki N, Stangl K, Stewart A, Stringer B, Tamarappoo B, Tamura Y, Thuny F, Tierney S, Tresorier R, Ullah W, Von Hunolstein J, Warner E, Weppler A. Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry. European Journal Of Cancer 2022, 177: 197-205. PMID: 36030143, PMCID: PMC10165738, DOI: 10.1016/j.ejca.2022.07.018.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseImmune checkpoint blockersCoronary revascularizationArtery diseaseCAD groupInternational registryPrompt clinical diagnosisAcute coronary syndromeCoronary artery stenosisAdjustment of ageCause deathCoronary syndromeIndex hospitalisationSteroid administrationCheckpoint blockersCoronary angiographyArtery stenosisCoronary angiogramPoor outcomeSevere presentationRevascularizationPatientsCardiac pathologyClinical diagnosisMyocarditis
2021
Cardiac Computed Tomography in Cardio-Oncology JACC: CardioOncology Primer
Lopez-Mattei JC, Yang EH, Ferencik M, Baldassarre LA, Dent S, Budoff MJ. Cardiac Computed Tomography in Cardio-Oncology JACC: CardioOncology Primer. JACC CardioOncology 2021, 3: 635-649. PMID: 34988472, PMCID: PMC8702811, DOI: 10.1016/j.jaccao.2021.09.010.Peer-Reviewed Original ResearchAtherosclerotic cardiovascular diseaseSubclinical atherosclerotic cardiovascular diseaseCancer patientsPericardial diseaseCardiac CTCancer treatment-related cardiovascular toxicityValvular heart diseaseCardiac computed tomographyCardiac magnetic resonanceCardiac tumorsCardiovascular complicationsCardiovascular riskCalcium scoreHeart failureNoncancer patientsCardiovascular toxicityHeart diseaseCardiovascular diseaseCT scanComputed tomographyPatientsRadiation therapy treatmentTherapy treatmentDiseaseNew subspecialtyClinical Impact of Cardiovascular Magnetic Resonance in Cancer Patients With Suspected Cardiomyopathy
Heidari-Bateni G, Durand J, Iliescu C, Gladish G, Deswal A, Patel A, Kim P, Song J, Hassan S, Palaskas N, Baldassarre L, Bucciarelli-Ducci C, Lopez-Mattei J. Clinical Impact of Cardiovascular Magnetic Resonance in Cancer Patients With Suspected Cardiomyopathy. Frontiers In Cardiovascular Medicine 2021, 8: 734820. PMID: 34765654, PMCID: PMC8576269, DOI: 10.3389/fcvm.2021.734820.Peer-Reviewed Original ResearchLeft ventricular ejection fractionCardiovascular magnetic resonanceHigher left ventricular ejection fractionTertiary cancer centerCancer patientsClinical impactInfiltrative cardiomyopathyMultiple myelomaCancer CenterPresumptive diagnosisClinical diagnosisCardio-oncology practiceCancer diagnosisVentricular ejection fractionSignificant clinical impactClinical decision makingLogistic regression modelsBaseline characteristicsConsecutive patientsEjection fractionEndomyocardial biopsyDiverse etiologiesCMR resultsMagnetic resonancePatientsAdverse cardiovascular events in patients treated with mogamulizumab
Kwan J, Henry M, Cook K, Higgins A, Cuomo J, Foss F, Baldassarre L. Adverse cardiovascular events in patients treated with mogamulizumab. American Heart Journal Plus Cardiology Research And Practice 2021, 9: 100049. PMID: 38559371, PMCID: PMC10978139, DOI: 10.1016/j.ahjo.2021.100049.Peer-Reviewed Original ResearchAdverse cardiovascular eventsMogamulizumab therapyCardiovascular eventsHeart failureAdverse outcomesNon-cardiovascular eventsWorld Health Organization databaseFatal adverse outcomesT-cell leukemiaACE occurrenceMogamulizumab treatmentNew hypertensionAdverse eventsCardiac deathVentricular arrhythmiasFatal outcomeUnique patientsCardiovascular toxicityMyocardial infarctionImportant treatmentHigh mortalityPatientsMogamulizumabTherapyOrganization databaseRationale and proposed framework for shared decision making in cardio-oncology
Hull SC, Soufer A, Spatz ES, Baldassarre LA. Rationale and proposed framework for shared decision making in cardio-oncology. Cardio-Oncology 2021, 7: 30. PMID: 34425913, PMCID: PMC8380868, DOI: 10.1186/s40959-021-00118-7.Peer-Reviewed Original ResearchMogamulizumab-Associated Acute Myocarditis in a Patient With T-Cell Lymphoma
Kwan JM, Odanovic N, Arbune A, Higgins A, Henry M, Greif D, Foss F, Baldassarre LA. Mogamulizumab-Associated Acute Myocarditis in a Patient With T-Cell Lymphoma. JACC Case Reports 2021, 3: 1018-1023. PMID: 34317676, PMCID: PMC8311348, DOI: 10.1016/j.jaccas.2021.04.001.Peer-Reviewed Original ResearchAortic Delamination—A Possible Precursor of Impending Catastrophe
Saeyeldin A, Zafar MA, Baldassarre LA, Mojibian H, Ziganshin BA, Mukherjee SK, Elefteriades JA. Aortic Delamination—A Possible Precursor of Impending Catastrophe. International Journal Of Angiology 2021, 30: 160-164. PMID: 34054275, PMCID: PMC8159620, DOI: 10.1055/s-0040-1718546.Peer-Reviewed Original ResearchAortic wall thicknessAdverse aortic eventsAortic eventsChest painDeep hypothermic circulatory arrestHypothermic circulatory arrestAortic repairAortic ruptureCirculatory arrestOpen repairAortic catastropheAortic diameterSurgical pathologyLimited evidencePowerful predictorPainPatientsDissectionSurgical videosRepairWall thicknessPathology
2020
Cardiovascular Care of the Oncology Patient During COVID-19: An Expert Consensus Document From the ACC Cardio-Oncology and Imaging Councils
Baldassarre LA, Yang EH, Cheng RK, DeCara JM, Dent S, Liu JE, Rudski LG, Strom JB, Thavendiranathan P, Barac A, Zaha VG, Bucciarelli-Ducci C, Ellahham S, Deswal A, Lenneman C, Villarraga HR, Blaes AH, Ismail-Khan R, Ky B, Leja MJ, Scherrer-Crosbie M. Cardiovascular Care of the Oncology Patient During COVID-19: An Expert Consensus Document From the ACC Cardio-Oncology and Imaging Councils. Journal Of The National Cancer Institute 2020, 113: 513-522. PMID: 33179744, PMCID: PMC7717327, DOI: 10.1093/jnci/djaa177.Peer-Reviewed Original ResearchConceptsCardio-OncologyCardiovascular careCOVID-19Cardio-oncology patientsPrior cancer historyExpert consensus statementCoronavirus disease 2019 (COVID-19) pandemicExpert consensus documentRisk of infectionDisease 2019 pandemicCardiotoxicity surveillanceCardiovascular complicationsPericardial involvementLethal complicationCardiac dysfunctionOncology patientsRisk of exposureCancer historyCancer patientsCardiovascular diseaseConsensus statementAmerican CollegeCardiovascular treatmentConsensus documentPatients
2019
Valvular imaging in the era of feature‐tracking: A slice‐following cardiac MR sequence to measure mitral flow
Seemann F, Heiberg E, Carlsson M, Gonzales RA, Baldassarre LA, Qiu M, Peters DC. Valvular imaging in the era of feature‐tracking: A slice‐following cardiac MR sequence to measure mitral flow. Journal Of Magnetic Resonance Imaging 2019, 51: 1412-1421. PMID: 31654470, PMCID: PMC7217167, DOI: 10.1002/jmri.26971.Peer-Reviewed Original ResearchConceptsMitral valve dysfunctionAortic stroke volumeStroke volumeHealthy subjectsValve dysfunctionMitral flowMitral valveMitral flow patternTransmitral blood flowMitral stroke volumeStage 2 J. MagnDiastolic functionMitral regurgitationTransmitral flowCine phase contrastDysfunction patientsClinical examinationBland-Altman analysisPhase-contrast sequenceBlood flowJ. MagnImportant clinical examinationTechnical efficacyPatientsT-testNuclear cardiology in the context of multimodality imaging to detect cardiac toxicity from cancer therapeutics: Established and emerging methods
Soufer A, Liu C, Henry ML, Baldassarre LA. Nuclear cardiology in the context of multimodality imaging to detect cardiac toxicity from cancer therapeutics: Established and emerging methods. Journal Of Nuclear Cardiology 2019, 27: 1210-1224. PMID: 30868378, DOI: 10.1007/s12350-019-01671-6.Peer-Reviewed Original ResearchConceptsCardiac toxicityPre-clinical cardiotoxicityCardiac magnetic resonanceNuclear cardiologyCardiovascular outcomesNon-invasive imagingCardiovascular toxicityChemotherapeutic agentsCancer treatmentEarly detectionCardiac imagingCancer therapyCancer therapeuticsCardiologyToxicityMagnetic resonanceTreatmentImagingEchocardiographyPatientsCardiotoxicityTherapyCancerSeverityCareCARDIAC MAGNETIC RESONANCE IMAGING FEATURE TRACKING STRAIN AS A SENSITIVE MARKER OF CARDIOTOXICITY IN BREAST CANCER PATIENTS COMPARED WITH LEFT VENTRICULAR EJECTION FRACTION
Kwan J, Arbune A, Henry M, Dupee D, Soufer A, Baldassarre L. CARDIAC MAGNETIC RESONANCE IMAGING FEATURE TRACKING STRAIN AS A SENSITIVE MARKER OF CARDIOTOXICITY IN BREAST CANCER PATIENTS COMPARED WITH LEFT VENTRICULAR EJECTION FRACTION. Journal Of The American College Of Cardiology 2019, 73: 1666. DOI: 10.1016/s0735-1097(19)32272-7.Peer-Reviewed Original ResearchUsing FDG-PET to guide targeted cardiac magnetic resonance imaging in patients with suspected cardiac sarcoidosis
Sharp MB, Soufer A, Abdelmessih M, Rosenfeld LE, Baldassarre LA, Miller EJ. Using FDG-PET to guide targeted cardiac magnetic resonance imaging in patients with suspected cardiac sarcoidosis. Journal Of Nuclear Cardiology 2019, 27: 688-690. PMID: 30737635, DOI: 10.1007/s12350-019-01640-z.Peer-Reviewed Original Research
2016
Noninvasive Imaging to Evaluate Women With Stable Ischemic Heart Disease
Baldassarre LA, Raman SV, Min JK, Mieres JH, Gulati M, Wenger NK, Marwick TH, Bucciarelli-Ducci C, Merz C, Itchhaporia D, Ferdinand KC, Pepine CJ, Walsh MN, Narula J, Shaw LJ, Committee A. Noninvasive Imaging to Evaluate Women With Stable Ischemic Heart Disease. JACC Cardiovascular Imaging 2016, 9: 421-435. PMID: 27056162, PMCID: PMC5486953, DOI: 10.1016/j.jcmg.2016.01.004.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseHeart diseaseSymptoms of IHDSymptomatic ischemic heart diseaseStable ischemic heart diseasePotential therapeutic strategyCardiovascular deathSymptomatic womenIHD riskWorse outcomesContemporary imagingTherapeutic strategiesNoninvasive imagingRisk predictionWomenImaging targetsDiseaseMajor determinantFunctional differencesImagingMale counterpartsPatientsSymptoms