2024
Artificial intelligence applied to electrocardiographic images for the risk stratification of cancer therapeutics-related cardiac dysfunction
Oikonomou E, Sangha V, Dhingra L, Aminorroaya A, Coppi A, Krumholz H, Baldassarre L, Khera R. Artificial intelligence applied to electrocardiographic images for the risk stratification of cancer therapeutics-related cardiac dysfunction. European Heart Journal 2024, 45: ehae666.3190. DOI: 10.1093/eurheartj/ehae666.3190.Peer-Reviewed Original ResearchCancer therapeutics-related cardiac dysfunctionImmune checkpoint inhibitorsGlobal longitudinal strainLeft ventricular systolic dysfunctionNon-Hodgkin's lymphomaCardiac dysfunctionAI-ECGNegative control analysesAssociated with higher incidenceVentricular systolic dysfunctionCohort of patientsRisk stratification strategiesCheckpoint inhibitorsTrastuzumab exposureSystolic dysfunctionRisk stratificationBreast cancerRisk biomarkersSecondary outcomesLongitudinal strainStratification strategiesTrastuzumabPatientsHigher incidenceAnthracyclines
2021
57884 Fast strain-encoded cardiac magnetic resonance detects immune checkpoint inhibitor associated cardiotoxicity
Cuomo J, Ragheb E, Feher A, Kwan J, Huber S, Mojibian H, Peters D, Sinusas A, Baldassarre L. 57884 Fast strain-encoded cardiac magnetic resonance detects immune checkpoint inhibitor associated cardiotoxicity. Journal Of Clinical And Translational Science 2021, 5: 141-142. PMCID: PMC8827987, DOI: 10.1017/cts.2021.761.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsVentricular ejection fractionLV strainCardiotoxicity groupCheckpoint inhibitorsEjection fractionProspective studyCardiac functionNormal left ventricular ejection fractionLeft ventricular ejection fractionCardiac magnetic resonance imagingCardiac magnetic resonance imaging techniquesGlobal longitudinal LV strainAbnormal troponin valuesEvidence of cardiotoxicityProportion of myocardiumLarge prospective studiesLongitudinal LV strainStudy of patientsSteady-state free precession cine imagesAbnormal cardiac functionCircumferential LV strainT2-weighted imagingMagnetic resonance imagingDysfunctional segmentsLeft ventricular myocardial strain and tissue characterization by cardiac magnetic resonance imaging in immune checkpoint inhibitor associated cardiotoxicity
Higgins AY, Arbune A, Soufer A, Ragheb E, Kwan JM, Lamy J, Henry M, Cuomo JR, Charifa A, Gallegos C, Hull S, Coviello JS, Bader AS, Peters DC, Huber S, Mojibian HR, Sinusas AJ, Kluger H, Baldassarre LA. Left ventricular myocardial strain and tissue characterization by cardiac magnetic resonance imaging in immune checkpoint inhibitor associated cardiotoxicity. PLOS ONE 2021, 16: e0246764. PMID: 33606757, PMCID: PMC7895343, DOI: 10.1371/journal.pone.0246764.Peer-Reviewed Original ResearchConceptsGlobal longitudinal strainImmune checkpoint inhibitorsLate gadolinium enhancementRecovery of LVEFLake Louise criteriaCheckpoint inhibitorsNormal LVEFAverage global longitudinal strainPresence of LGEAbnormal global longitudinal strainCardiac magnetic resonance imagingCorrect clinical contextEvaluation of myocarditisLeft ventricular dysfunctionVentricular ejection fractionDiagnosis of myocarditisLeft ventricular strainCardiac magnetic resonanceLeft ventricular myocardial strainOvert left ventricular dysfunctionVentricular myocardial strainMagnetic resonance imagingAtrial strainVentricular dysfunctionVentricular strain
2020
Clinical and Advanced MRI Techniques for Detection of Checkpoint Inhibitor Associated Myocarditis
Arbune A, Soufer A, Baldassarre L. Clinical and Advanced MRI Techniques for Detection of Checkpoint Inhibitor Associated Myocarditis. Current Cardiovascular Imaging Reports 2020, 13: 3. DOI: 10.1007/s12410-019-9521-5.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsEndomyocardial biopsyAdverse eventsCases of ICIImmune-related adverse eventsCardiac magnetic resonance imagingImmune adverse eventsDiagnosis of myocarditisBiventricular ejection fractionAdvanced MRI techniquesInvasive endomyocardial biopsyMagnetic resonance imagingPurpose of ReviewWithGold standard testAssociated myocarditisCheckpoint inhibitorsCMR findingsMyocardial inflammationEjection fractionSerial monitoringNoninvasive testsPrognostic informationTissue characterization informationCardiac biomarkersParametric mapping techniques
2019
The Role of Cardiac Magnetic Resonance Imaging to Detect Cardiac Toxicity From Cancer Therapeutics
Soufer A, Baldassarre LA. The Role of Cardiac Magnetic Resonance Imaging to Detect Cardiac Toxicity From Cancer Therapeutics. Current Treatment Options In Cardiovascular Medicine 2019, 21: 28. PMID: 31104180, DOI: 10.1007/s11936-019-0732-5.Peer-Reviewed Original ResearchCardiac magnetic resonanceCardiac toxicityCardiac magnetic resonance imagingNon-invasive workupImmune checkpoint inhibitorsSubclinical LV dysfunctionMyocardial tissue characteristicsCancer therapyPurpose of ReviewTheMagnetic resonance imagingCheckpoint inhibitorsLA fibrosisLV dysfunctionMicrocirculatory dysfunctionNon-invasive methodMagnetic resonanceCardiac structureResonance imagingMyocardial strainTissue characteristicsDysfunctionCancer therapeuticsTherapyToxicityFurther researchMyocarditis with checkpoint inhibitor immunotherapy: case report of late gadolinium enhancement on cardiac magnetic resonance with pathology correlate
Gallegos C, Rottmann D, Nguyen VQ, Baldassarre LA. Myocarditis with checkpoint inhibitor immunotherapy: case report of late gadolinium enhancement on cardiac magnetic resonance with pathology correlate. European Heart Journal - Case Reports 2019, 3: yty149. PMID: 31020225, PMCID: PMC6439394, DOI: 10.1093/ehjcr/yty149.Peer-Reviewed Case Reports and Technical NotesLate gadolinium enhancementCardiovascular magnetic resonanceCardiac complicationsGadolinium enhancementAnti-programmed cell death protein 1 monoclonal antibodyCell death protein 1 monoclonal antibodyLeft ventricular ejection fractionNon-ischemic patternAcute heart failureCheckpoint inhibitor therapyRefractory cardiogenic shockCarotid artery dissectionCheckpoint inhibitor immunotherapyVentricular ejection fractionArea of myocardiumCardiac magnetic resonanceDirect histological correlationAreas of LGEArtery dissectionCardiogenic shockCheckpoint inhibitorsImmunosuppressive therapyVentricular dysfunctionEjection fractionHeart failure