2024
Chronic Overlapping Pain Conditions and Nociplastic Pain
Johnston K, Signer R, Huckins L. Chronic Overlapping Pain Conditions and Nociplastic Pain. Human Genetics And Genomics Advances 2024, 100381. PMID: 39497418, DOI: 10.1016/j.xhgg.2024.100381.Peer-Reviewed Original ResearchGenome wide association studiesTranscriptome-wide associationChronic overlapping pain conditionsTissue enrichment analysisSingle nucleotide polymorphismsEnrichment analysisNociplastic painPain conditionsIndependent single nucleotide polymorphismsMultisite chronic painGene set enrichment analysisSNP heritabilityUnique genesNeuropathic pain phenotypesAssociation studiesPolygenic traitChronic pain conditionsGene setsNucleotide polymorphismsMetabolic traitsHeritable traitGenetic overlapPain phenotypesPain descriptorsPain experience
2023
Genetically Regulated Gene Expression in the Brain Associated With Chronic Pain: Relationships With Clinical Traits and Potential for Drug Repurposing
Johnston K, Cote A, Hicks E, Johnson J, Huckins L. Genetically Regulated Gene Expression in the Brain Associated With Chronic Pain: Relationships With Clinical Traits and Potential for Drug Repurposing. Biological Psychiatry 2023, 95: 745-761. PMID: 37678542, PMCID: PMC10924073, DOI: 10.1016/j.biopsych.2023.08.023.Peer-Reviewed Original ResearchConceptsGenetically regulated gene expressionMultisite chronic painGene-tissue associationsMean pain scoreUnique genesChronic painAssociation studiesS-PrediXcanGene expressionPain scoresTranscriptome-wide association studyPhenome-wide association studyCardiac dysrhythmiasMetabolic syndromeGenome-wide association studiesAssociated with cardiac dysrhythmiasDrug targetsGenotype-phenotype gapChronic pain developmentAssociation study resultsGene expression changesJoint/ligament sprainsDirection of effectTranscriptome imputationPain traits