2023
Transcriptional signatures of heroin intake and relapse throughout the brain reward circuitry in male mice
Browne C, Futamura R, Minier-Toribio A, Hicks E, Ramakrishnan A, Martínez-Rivera F, Estill M, Godino A, Parise E, Torres-Berrío A, Cunningham A, Hamilton P, Walker D, Huckins L, Hurd Y, Shen L, Nestler E. Transcriptional signatures of heroin intake and relapse throughout the brain reward circuitry in male mice. Science Advances 2023, 9: eadg8558. PMID: 37294757, PMCID: PMC10256172, DOI: 10.1126/sciadv.adg8558.Peer-Reviewed Original ResearchConceptsOpioid use disorderHeroin intakeContext-induced drug-seekingBrain reward circuitryHeroin self-administrationRNA-seqDrug seekingReward circuitryGenome-wide association study dataSelf-administrationHeroin exposureDrug-takingIntegration of RNA-seq dataUse disorderPatterns of transcriptional regulationRNA-seq dataBehavioral outcomesMale miceMolecular changesTranscriptional regulationRegion-specificGene candidatesRNA sequencingHeroinBioinformatics analysis
2017
Novel Bipolar And Schizophrenia Risk Genes Identified Through Genic Associations In Transcriptome Imputation
Huckins L, Dobbyn A, Ruderfer D, Fromer M, Consortium C, Cox N, Im H, Sieberts S, Devlin B, Roussos P, Purcell S, Sklar P, Stahl E. Novel Bipolar And Schizophrenia Risk Genes Identified Through Genic Associations In Transcriptome Imputation. European Neuropsychopharmacology 2017, 27: s487. DOI: 10.1016/j.euroneuro.2016.09.577.Peer-Reviewed Original ResearchPsychiatric Genomics ConsortiumGenome-wide significanceGenic associationsGene expressionAssociation studiesPsychiatric Genomics Consortium schizophreniaRisk genesLarge-scale transcriptome datasetsVariants regulate gene expressionBackgroundGenome-wide association studiesTissue-specific gene expression levelsGWAS sample sizeNovel risk genesRNA-seq dataBipolar disorderSchizophrenia risk genesBiologically relevant dataCase-control sampleGWAS lociGene expression levelsGenome-wideGWAS datasetDisease architectureGenomic regionsTop loci