2024
Comorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome
Hicks E, Niarchou M, Goleva S, Kabir D, Johnson J, Johnston K, Ciarcia J, Pathak G, Smoller J, Davis L, Nievergelt C, Koenen K, Huckins L, Choi K, Group P. Comorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome. Biological Psychiatry Global Open Science 2024, 4: 100337. PMID: 39050781, PMCID: PMC11268109, DOI: 10.1016/j.bpsgos.2024.100337.Peer-Reviewed Original ResearchElectronic health recordsClinical knowledge gapsPhysical health problemsPhenome-wide associationPheWAS analysisBiobank participantsHealth recordsEpidemiological researchHealthcare systemTest associationsMedical phenomeAssociated with osteoporosisPulmonary heart diseasePhecodesHealth problemsLogistic regressionPosttraumatic stress disorderSex differencesPheWASComorbidity profilesHeart diseaseStress disorderInteraction termsAssociationPTSD
2022
Trauma Matters: Integrating Genetic and Environmental Components of PTSD
Marchese S, Huckins L. Trauma Matters: Integrating Genetic and Environmental Components of PTSD. Advanced Genetics 2022, 4: 2200017. PMID: 37766803, PMCID: PMC10520418, DOI: 10.1002/ggn2.202200017.Peer-Reviewed Original ResearchAltered gene expression and PTSD symptom dimensions in World Trade Center responders
Marchese S, Cancelmo L, Diab O, Cahn L, Aaronson C, Daskalakis NP, Schaffer J, Horn SR, Johnson JS, Schechter C, Desarnaud F, Bierer LM, Makotkine I, Flory JD, Crane M, Moline JM, Udasin IG, Harrison DJ, Roussos P, Charney DS, Koenen KC, Southwick SM, Yehuda R, Pietrzak RH, Huckins LM, Feder A. Altered gene expression and PTSD symptom dimensions in World Trade Center responders. Molecular Psychiatry 2022, 27: 2225-2246. PMID: 35177824, DOI: 10.1038/s41380-022-01457-2.Peer-Reviewed Original ResearchConceptsPTSD symptom dimensionsPosttraumatic stress disorderCAPS scoresAnxious arousal symptomsSymptom dimensionsWorld Trade Center rescueClinician-Administered PTSD Scale scoresBiomarker of PTSDArousal symptomsCD4 T cellsWorld Trade Center respondersDevelopment of PTSDTotal CAPS scoresCase/control statusTherapeutic target developmentIdentification of biomarkersClinical interview dataResponder cohortPTSD symptom severityPotential biological differencesWTC respondersT cellsGene expressionPTSD studiesPsychiatric disorders
2021
Internet-based cognitive behavioral therapy versus internet-based modified present-centered therapy for world trade center responders and survivors with posttraumatic stress disorder: rationale and design of a randomized controlled trial
Brinkman H, Kowalchyk M, Cahn L, Aaronson C, Böttche M, Presseau C, Markowitz J, Litz B, Huckins L, Yehuda R, Knaevelsrud C, Pietrzak R, Feder A. Internet-based cognitive behavioral therapy versus internet-based modified present-centered therapy for world trade center responders and survivors with posttraumatic stress disorder: rationale and design of a randomized controlled trial. International Journal Of Clinical Trials 2021, 8: 202-210. DOI: 10.18203/2349-3259.ijct20212843.Peer-Reviewed Original ResearchInternet-based cognitive behavioral therapyCognitive behavioral therapyBehavioral therapyActive comparison treatmentsWorld Trade Center respondersPosttraumatic stress disorder (PTSD) symptomsEvidence-based treatmentsDesign of trialsQuality of lifeTrauma-affected populationsPost-traumatic growthPosttraumatic stress disorderWTC rescueThird variable explanationsActive treatmentWTC workersComorbid depressiveWTC respondersTreatment responseCBT trialsCBT interventionTherapyPTSD symptomsRecovery workersCBT studies
2018
Recent Genetics and Epigenetics Approaches to PTSD
Daskalakis N, Rijal C, King C, Huckins L, Ressler K. Recent Genetics and Epigenetics Approaches to PTSD. Current Psychiatry Reports 2018, 20: 30. PMID: 29623448, PMCID: PMC6486832, DOI: 10.1007/s11920-018-0898-7.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderTrauma exposureGenome-wide association studiesEpigenetic approachesTargeted genetic studiesEpigenome-wide studiesInduce epigenetic changesResponse to trauma exposureAssociation studiesAdult trauma exposureGenetic studiesNegative emotional symptomsEpigenetic alterationsEpigenetic changesFunctional regulationEpigenetic riskIntrusive memoriesStress disorderTraumatic exposureImpaired cognitionEmotional symptomsAvoidance behaviorDisability syndromeBiological riskElectronic medical records