2023
29. GENE EXPRESSION ASSOCIATIONS WITH TRAUMA IN HUMAN POSTMORTEM BRAIN
Hicks E, Seah C, Cote A, Ciarcia J, Chakka A, Group T, Brennand K, Nestler E, Girgenti M, Huckins L. 29. GENE EXPRESSION ASSOCIATIONS WITH TRAUMA IN HUMAN POSTMORTEM BRAIN. European Neuropsychopharmacology 2023, 75: s72. DOI: 10.1016/j.euroneuro.2023.08.139.Peer-Reviewed Original ResearchMajor depressive disorderPost-traumatic stress disorderHuman postmortem brainPostmortem brainsPsychiatric disordersNeurobiological consequencesTranscriptional signatureMajor precipitating factorEarly life stressCase/control statusGene expression associationsType of traumaStress-related disordersTrauma measuresTrauma-exposed individualsTraumatic Stress DisorderExpression associationsBrain donorsDepressive disorderMale miceFrontal cortexPrecipitating factorsMouse modelAnimal modelsPsychosocial stress
2022
Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Seah C, Breen M, Rusielewicz T, Bader H, Xu C, Hunter C, McCarthy B, Deans P, Chattopadhyay M, Goldberg J, Desarnaud F, Makotkine I, Flory J, Bierer L, Staniskyte M, Noggle S, Huckins L, Paull D, Brennand K, Yehuda R. Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression. Nature Neuroscience 2022, 25: 1434-1445. PMID: 36266471, PMCID: PMC9630117, DOI: 10.1038/s41593-022-01161-y.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderPeripheral blood mononuclear cellsGlucocorticoid-induced changesGlucocorticoid-induced gene expressionBlood mononuclear cellsIndividual clinical outcomesEnvironmental risk factorsHuman postmortem brainGlucocorticoid hypersensitivityClinical outcomesGlutamatergic neuronsMononuclear cellsRisk factorsHydrocortisone exposureSevere traumaPostmortem brainsHuman neuronsGlucocorticoid responseInduced neuronsStress disorderNeuronsNew therapeuticsGene expressionGene × environment interactionsCombat veterans