2024
42. STRESS EXPOSURE DYNAMICALLY REGULATES EQTL ACTIVITY IN THE POST-MORTEM BRAIN AND IN HIPSC-DERIVED NEURONS
Seah C, Signer R, Young H, Hicks E, Rusielewicz T, Bader H, Xu C, Breen M, Paull D, Yehuda R, Girgenti M, Brennand K, Huckins L. 42. STRESS EXPOSURE DYNAMICALLY REGULATES EQTL ACTIVITY IN THE POST-MORTEM BRAIN AND IN HIPSC-DERIVED NEURONS. European Neuropsychopharmacology 2024, 87: 71-72. DOI: 10.1016/j.euroneuro.2024.08.156.Peer-Reviewed Original ResearchPost-mortem brainsTranscription factor binding sitesAbsence of cellular stressCombat-exposed veteransFactor binding sitesImpact gene expressionBinding sitesGR binding sitesPositive regulatory activityMotif enrichmentSequence readsCRISPRi screenOpen chromatinFunctional annotationBrain regionsTraumatic stressCRISPR screensEQTLTraumatic experiencesLeading locusPTSDPerturbed genesRegulatory architectureTranscriptomic activityTranscriptomic responseComorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome
Hicks E, Niarchou M, Goleva S, Kabir D, Johnson J, Johnston K, Ciarcia J, Pathak G, Smoller J, Davis L, Nievergelt C, Koenen K, Huckins L, Choi K, Group P. Comorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome. Biological Psychiatry Global Open Science 2024, 4: 100337. PMID: 39050781, PMCID: PMC11268109, DOI: 10.1016/j.bpsgos.2024.100337.Peer-Reviewed Original ResearchElectronic health recordsClinical knowledge gapsPhysical health problemsPhenome-wide associationPheWAS analysisBiobank participantsHealth recordsEpidemiological researchHealthcare systemTest associationsMedical phenomeAssociated with osteoporosisPulmonary heart diseasePhecodesHealth problemsLogistic regressionPosttraumatic stress disorderSex differencesPheWASComorbidity profilesHeart diseaseStress disorderInteraction termsAssociationPTSD
2022
EPIGENOME-WIDE PREDICTORS OF RESPONSE TO INTERNET-BASED COGNITIVE-BEHAVIORAL THERAPY FOR PTSD IN WORLD TRADE CENTER TRAUMA SURVIVORS
Kozik E, Kowalchyk M, Brinkman H, Desarnaud F, Yehuda R, Pietrzak R, Huckins L, Feder A. EPIGENOME-WIDE PREDICTORS OF RESPONSE TO INTERNET-BASED COGNITIVE-BEHAVIORAL THERAPY FOR PTSD IN WORLD TRADE CENTER TRAUMA SURVIVORS. European Neuropsychopharmacology 2022, 63: e130. DOI: 10.1016/j.euroneuro.2022.07.242.Peer-Reviewed Original ResearchSex-Stratified Relationships Between PTSD Phenotypes and the Medical Phenome Using Electronic Health Records
Choi K, Goleva S, Huckins L, Kozak E, Smoller J, Nievergelt C, Koenen K, Davis L. Sex-Stratified Relationships Between PTSD Phenotypes and the Medical Phenome Using Electronic Health Records. Biological Psychiatry 2022, 91: s3. DOI: 10.1016/j.biopsych.2022.02.026.Peer-Reviewed Original Research