2023
W22. DISENTANGLING THE ROLES OF GENETICS AND BODY MASS INDEX ACROSS PSYCHIATRIC DISORDERS
Signer R, Seah C, Young H, de Pins A, Johnson J, Cote A, Huckins L. W22. DISENTANGLING THE ROLES OF GENETICS AND BODY MASS INDEX ACROSS PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2023, 75: s116. DOI: 10.1016/j.euroneuro.2023.08.213.Peer-Reviewed Original ResearchExpression quantitative trait lociBody mass indexGenome-wide association studiesEffect of body mass indexAssociation studiesAvailability of genome-wide association studyGenetic riskPhenome-wide association studyIndirect effect of body mass indexPsychiatric disordersBody mass index spectrumStatistical fine-mappingQuantitative trait lociGenetic risk modelsCell-type specific mannerTissue enrichmentImpact of body mass indexGWAS lociTranscriptome imputationGenomic lociWhole genomeFine-mappingTrait lociGenomic underpinningsPhenotypic consequences
2022
Mapping anorexia nervosa genes to clinical phenotypes
Johnson J, Cote A, Dobbyn A, Sloofman L, Xu J, Cotter L, Charney A, Consortium E, Birgegård A, Jordan J, Kennedy M, Landén M, Maguire S, Martin N, Mortensen P, Thornton L, Bulik C, Huckins L. Mapping anorexia nervosa genes to clinical phenotypes. Psychological Medicine 2022, 53: 2619-2633. PMID: 35379376, PMCID: PMC10123844, DOI: 10.1017/s0033291721004554.Peer-Reviewed Original ResearchConceptsBody mass indexGenome-wide association studiesTranscriptome imputationElectronic health record phenotypingAssociation studiesPhenome-wide association studyS-PrediXcan analysisMeasurement of cholesterolTraditional genome-wide association studiesGenes associated with ANAssociation of genetic variantsSubstance useGenetically regulated gene expressionImpact of body mass indexConsequences of aberrant expressionBiobank cohortBiobank populationAssociated with measuresAssociation of ANGWAS findingsSecondary analysisS-PrediXcanDisease riskMass indexSignificant genes