2024
23. GENOME-WIDE ASSOCIATION STUDIES OF BINGE-EATING BEHAVIOUR AND ANOREXIA NERVOSA YIELD INSIGHTS INTO THE UNIQUE AND SHARED BIOLOGY OF EATING DISORDER PHENOTYPES
Huckins L, Termorshuizen J, Davies H, Lee S, Johnson J, Munn-Chernoff M, Thornton L, Källberg J, Bulik C, Breen G, Coleman J. 23. GENOME-WIDE ASSOCIATION STUDIES OF BINGE-EATING BEHAVIOUR AND ANOREXIA NERVOSA YIELD INSIGHTS INTO THE UNIQUE AND SHARED BIOLOGY OF EATING DISORDER PHENOTYPES. European Neuropsychopharmacology 2024, 87: 60. DOI: 10.1016/j.euroneuro.2024.08.137.Peer-Reviewed Original ResearchGenome-wide association studiesIdentification of novel lociGenome-wide association study meta-analysisGenetic correlationsEating Disorders Working GroupBinge-eating behaviorNovel lociGenome-wideGenomic lociAssociation studiesLociGenetic componentEating disorder phenotypesPhenotypeEarly onset obesityBE phenotypeSevere early onset obesityDisorder phenotypesTrans-diagnosticAN subtypesAN-BPAN-RAN-R.Eating disordersBinge-eating/purging
2017
Novel Bipolar And Schizophrenia Risk Genes Identified Through Genic Associations In Transcriptome Imputation
Huckins L, Dobbyn A, Ruderfer D, Fromer M, Consortium C, Cox N, Im H, Sieberts S, Devlin B, Roussos P, Purcell S, Sklar P, Stahl E. Novel Bipolar And Schizophrenia Risk Genes Identified Through Genic Associations In Transcriptome Imputation. European Neuropsychopharmacology 2017, 27: s487. DOI: 10.1016/j.euroneuro.2016.09.577.Peer-Reviewed Original ResearchPsychiatric Genomics ConsortiumGenome-wide significanceGenic associationsGene expressionAssociation studiesPsychiatric Genomics Consortium schizophreniaRisk genesLarge-scale transcriptome datasetsVariants regulate gene expressionBackgroundGenome-wide association studiesTissue-specific gene expression levelsGWAS sample sizeNovel risk genesRNA-seq dataBipolar disorderSchizophrenia risk genesBiologically relevant dataCase-control sampleGWAS lociGene expression levelsGenome-wideGWAS datasetDisease architectureGenomic regionsTop loci