2024
What Next for Eating Disorder Genetics? Replacing Myths With Facts to Sharpen Our Understanding
Huckins L, Signer R, Johnson J, Wu Y, Mitchell K, Bulik C. What Next for Eating Disorder Genetics? Replacing Myths With Facts to Sharpen Our Understanding. FOCUS The Journal Of Lifelong Learning In Psychiatry 2024, 22: 418-429. PMID: 38988461, PMCID: PMC11231467, DOI: 10.1176/appi.focus.24022014.Peer-Reviewed Original Research
2023
Open Science Practices in Psychiatric Genetics: A Primer
Kępińska A, Johnson J, Huckins L. Open Science Practices in Psychiatric Genetics: A Primer. Biological Psychiatry Global Open Science 2023, 4: 110-119. PMID: 38298792, PMCID: PMC10829621, DOI: 10.1016/j.bpsgos.2023.08.007.Peer-Reviewed Original ResearchIntegrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings
Hicks E, Seah C, Cote A, Marchese S, Brennand K, Nestler E, Girgenti M, Huckins L. Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings. Translational Psychiatry 2023, 13: 129. PMID: 37076454, PMCID: PMC10115809, DOI: 10.1038/s41398-023-02412-7.Peer-Reviewed Original ResearchConceptsBioinformatics approachTranscriptomic dataBrain transcriptomeGenome-wide analysisDynamic transcriptional landscapeBrain gene expression dataGene expression dataTranscriptional landscapeTranscriptomic studiesIntegrating GeneticExpression dataPhenotypic signaturesGenomic driversTranscriptomeMajor depressive disorderValuable resourceRecent findingsEnvironmental influencesTranscriptomicsDepressive disorderGeneticsMultiple approachesPathophysiology of depressionSignaturesDysregulationSchizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations
Liu D, Meyer D, Fennessy B, Feng C, Cheng E, Johnson J, Park Y, Rieder M, Ascolillo S, de Pins A, Dobbyn A, Lebovitch D, Moya E, Nguyen T, Wilkins L, Hassan A, Burdick K, Buxbaum J, Domenici E, Frangou S, Hartmann A, Laurent-Levinson C, Malhotra D, Pato C, Pato M, Ressler K, Roussos P, Rujescu D, Arango C, Bertolino A, Blasi G, Bocchio-Chiavetto L, Campion D, Carr V, Fullerton J, Gennarelli M, González-Peñas J, Levinson D, Mowry B, Nimgaokar V, Pergola G, Rampino A, Cervilla J, Rivera M, Schwab S, Wildenauer D, Daly M, Neale B, Singh T, O’Donovan M, Owen M, Walters J, Ayub M, Malhotra A, Lencz T, Sullivan P, Sklar P, Stahl E, Huckins L, Charney A. Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations. Nature Genetics 2023, 55: 369-376. PMID: 36914870, PMCID: PMC10011128, DOI: 10.1038/s41588-023-01305-1.Peer-Reviewed Original ResearchConceptsProtein-truncating variantsRare protein-truncating variantsControls of diverse ancestryGenetic architecture of schizophreniaRare variant signalsProtein-coding regionsSchizophrenia risk genesCustom sequencing panelAncestral populationsAllelic spectrumGenetic architectureHuman populationDiverse ancestryHuman geneticsRisk genesVariant signalsGenesSequencing panelSchizophrenia casesSchizophrenia riskChronic mental illnessAncestryGeneticsMental illnessVariants
2022
What next for eating disorder genetics? Replacing myths with facts to sharpen our understanding
Huckins LM, Signer R, Johnson J, Wu YK, Mitchell KS, Bulik CM. What next for eating disorder genetics? Replacing myths with facts to sharpen our understanding. Molecular Psychiatry 2022, 27: 3929-3938. PMID: 35595976, PMCID: PMC9718676, DOI: 10.1038/s41380-022-01601-y.Peer-Reviewed Original Research
2019
International Society of Psychiatric Genetics Ethics Committee: Issues facing us
Lázaro‐Muñoz G, Sabatello M, Huckins L, Peay H, Degenhardt F, Meiser B, Lencz T, Soda T, Docherty A, Crepaz‐Keay D, Austin J, Peterson R, Davis L, Committee O. International Society of Psychiatric Genetics Ethics Committee: Issues facing us. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2019, 180: 543-554. PMID: 31124312, PMCID: PMC6861601, DOI: 10.1002/ajmg.b.32736.Peer-Reviewed Original ResearchConceptsInternational Society of Psychiatric GeneticsPsychiatric geneticsPsychiatric genetic researchGenetic researchELSI challengesGenetic counselorsClinical geneticistsEthics CommitteeGeneticsELSI issuesMental health professionalsLegal proceedingsClinical settingPatientsInternational organizationsEthical translationMental illnessInternational reachInternational SocietyBiological underpinningsGeneticistsELSIIncreased awarenessPsychiatric researchHealth professionals