2023
W22. DISENTANGLING THE ROLES OF GENETICS AND BODY MASS INDEX ACROSS PSYCHIATRIC DISORDERS
Signer R, Seah C, Young H, de Pins A, Johnson J, Cote A, Huckins L. W22. DISENTANGLING THE ROLES OF GENETICS AND BODY MASS INDEX ACROSS PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2023, 75: s116. DOI: 10.1016/j.euroneuro.2023.08.213.Peer-Reviewed Original ResearchExpression quantitative trait lociBody mass indexGenome-wide association studiesEffect of body mass indexAssociation studiesAvailability of genome-wide association studyGenetic riskPhenome-wide association studyIndirect effect of body mass indexPsychiatric disordersBody mass index spectrumStatistical fine-mappingQuantitative trait lociGenetic risk modelsCell-type specific mannerTissue enrichmentImpact of body mass indexGWAS lociTranscriptome imputationGenomic lociWhole genomeFine-mappingTrait lociGenomic underpinningsPhenotypic consequences
2017
Novel Bipolar And Schizophrenia Risk Genes Identified Through Genic Associations In Transcriptome Imputation
Huckins L, Dobbyn A, Ruderfer D, Fromer M, Consortium C, Cox N, Im H, Sieberts S, Devlin B, Roussos P, Purcell S, Sklar P, Stahl E. Novel Bipolar And Schizophrenia Risk Genes Identified Through Genic Associations In Transcriptome Imputation. European Neuropsychopharmacology 2017, 27: s487. DOI: 10.1016/j.euroneuro.2016.09.577.Peer-Reviewed Original ResearchPsychiatric Genomics ConsortiumGenome-wide significanceGenic associationsGene expressionAssociation studiesPsychiatric Genomics Consortium schizophreniaRisk genesLarge-scale transcriptome datasetsVariants regulate gene expressionBackgroundGenome-wide association studiesTissue-specific gene expression levelsGWAS sample sizeNovel risk genesRNA-seq dataBipolar disorderSchizophrenia risk genesBiologically relevant dataCase-control sampleGWAS lociGene expression levelsGenome-wideGWAS datasetDisease architectureGenomic regionsTop loci