STRESS IN A DISH: MODELING THE IMPACT OF COMMON GENETIC VARIATION ON STRESS RESPONSE IN HIPSC-DERIVED NEURONS IN PTSD
Seah C, Signer R, Young H, Kozik E, Rusielewicz T, Bader H, Xu C, de Pins A, Breen M, Paull D, Yehuda R, Girgenti M, Brennand K, Huckins L. STRESS IN A DISH: MODELING THE IMPACT OF COMMON GENETIC VARIATION ON STRESS RESPONSE IN HIPSC-DERIVED NEURONS IN PTSD. European Neuropsychopharmacology 2023, 75: s40. DOI: 10.1016/j.euroneuro.2023.08.081.Peer-Reviewed Original ResearchCommon genetic variationGenetic variationStress responseCell typesEQTL associationsTranscriptional stress responseGenomic risk lociTissue-specific mannerChIP-seq datasetsCell type deconvolutionCommon genetic variantsPost-mortem brainsGene expression signaturesHiPSC-derived neuronsTranscription factorsSuch lociCatalog genesRisk lociGenetic studiesExpression signaturesGenetic variantsRegulatory activityGenesEQTLsMechanistic understandingT70. A COMPUTATIONAL TRANSCRIPTOMICS APPROACH TO DRUG REPURPOSING IDENTIFIES NEW THERAPEUTIC CANDIDATES FOR TREATMENT OF CHRONIC PAIN
Cote A, Johnston K, Seah C, Young H, Charney A, Huckins L. T70. A COMPUTATIONAL TRANSCRIPTOMICS APPROACH TO DRUG REPURPOSING IDENTIFIES NEW THERAPEUTIC CANDIDATES FOR TREATMENT OF CHRONIC PAIN. European Neuropsychopharmacology 2023, 75: s199. DOI: 10.1016/j.euroneuro.2023.08.354.Peer-Reviewed Original ResearchResolution of acute painSeverity of chronic painChronic painAcute painExpression signaturesTreatment of chronic pain conditionsAcute low back painPresence of chronic painTreatment of chronic painChronic pain developmentChronic pain phenotypeChronic pain prevalenceChronic pain conditionsLow back painLong-term treatmentTherapeutic candidatePain symptom severityAnti-diabetic medicationsGene expression signaturesPain phenotypesDrug candidatesPain developmentBack painPain prevalencePain conditions