2024
W22. EATING DISORDERS OVER THE WEIGHT SPECTRUM: DISSECTING GENETIC DIFFERENCES OF EATING DISORDERS, THINNESS, AND OBESITY
Xu J, Signer R, Hicks E, Johnston K, Termorshuizen J, Group P, Bulik C, Huckins L. W22. EATING DISORDERS OVER THE WEIGHT SPECTRUM: DISSECTING GENETIC DIFFERENCES OF EATING DISORDERS, THINNESS, AND OBESITY. European Neuropsychopharmacology 2024, 87: 112. DOI: 10.1016/j.euroneuro.2024.08.231.Peer-Reviewed Original ResearchTissue-specific mannerSignificant genesCC-GWASGenetic distanceConstitutional thinnessIdentified multiple risk variantsBonferroni significanceGenome-wide lociGenome-wide significanceMultiple risk variantsConcordant effect directionsBinge eatingClinical differencesEating disordersGTEx v8S-PrediXcanAN-BGene associationsGenetic relationshipsRisk variantsRisk genesWeight-related traitsGenetic etiologyGenesDifferential expression23. GENOME-WIDE ASSOCIATION STUDIES OF BINGE-EATING BEHAVIOUR AND ANOREXIA NERVOSA YIELD INSIGHTS INTO THE UNIQUE AND SHARED BIOLOGY OF EATING DISORDER PHENOTYPES
Huckins L, Termorshuizen J, Davies H, Lee S, Johnson J, Munn-Chernoff M, Thornton L, Källberg J, Bulik C, Breen G, Coleman J. 23. GENOME-WIDE ASSOCIATION STUDIES OF BINGE-EATING BEHAVIOUR AND ANOREXIA NERVOSA YIELD INSIGHTS INTO THE UNIQUE AND SHARED BIOLOGY OF EATING DISORDER PHENOTYPES. European Neuropsychopharmacology 2024, 87: 60. DOI: 10.1016/j.euroneuro.2024.08.137.Peer-Reviewed Original ResearchGenome-wide association studiesIdentification of novel lociGenome-wide association study meta-analysisGenetic correlationsEating Disorders Working GroupBinge-eating behaviorNovel lociGenome-wideGenomic lociAssociation studiesLociGenetic componentEating disorder phenotypesPhenotypeEarly onset obesityBE phenotypeSevere early onset obesityDisorder phenotypesTrans-diagnosticAN subtypesAN-BPAN-RAN-R.Eating disordersBinge-eating/purgingOral Contraceptives and the Risk of Psychiatric Side Effects: A Review
Ciarcia J, Huckins L. Oral Contraceptives and the Risk of Psychiatric Side Effects: A Review. Complex Psychiatry 2024, 10: 36-44. PMID: 39148498, PMCID: PMC11324216, DOI: 10.1159/000539515.Peer-Reviewed Original ResearchMood-related side effectsPsychiatric side effectsPsychiatric riskOral contraceptivesSide effectsSymptoms of depressionPrescription psychotropic medicationsOC usersMood side effectsSide effects of oral contraceptivesEffects of oral contraceptivesMood symptomsRisks of oral contraceptivesOC treatmentPsychotropic medicationsMood improvementPsychiatric disordersEating disordersProgestin-only pillsSubgroups of usersPlacebo usersRandomized controlled trialsCombination pillMoodClinical significanceWhat Next for Eating Disorder Genetics? Replacing Myths With Facts to Sharpen Our Understanding
Huckins L, Signer R, Johnson J, Wu Y, Mitchell K, Bulik C. What Next for Eating Disorder Genetics? Replacing Myths With Facts to Sharpen Our Understanding. FOCUS The Journal Of Lifelong Learning In Psychiatry 2024, 22: 418-429. PMID: 38988461, PMCID: PMC11231467, DOI: 10.1176/appi.focus.24022014.Peer-Reviewed Original ResearchDissecting the biology of feeding and eating disorders
Huckins L, Brennand K, Bulik C. Dissecting the biology of feeding and eating disorders. Trends In Molecular Medicine 2024, 30: 380-391. PMID: 38431502, DOI: 10.1016/j.molmed.2024.01.009.Peer-Reviewed Original ResearchGenome-wide association studiesVariants to genesGenes to pathwaysSignificant lociFunctional genomicsAssociation studiesGenetic relationshipsIntestinal microbiotaGenetic researchGenomeGenetic correlationsGenesMetabolic contributorsAnorexia nervosaEating disordersPathwayBiologyMetabolic outcomesRisk factorsLociMicrobiotaPhenomicsLethal illnessTraitsFeeding
2019
Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches
Yao S, Kuja-Halkola R, Martin J, Lu Y, Lichtenstein P, Norring C, Birgegård A, Yilmaz Z, Hübel C, Watson H, Baker J, Almqvist C, Consortium E, Adan R, Ando T, Baker J, Bergen A, Berrettini W, Birgegård A, Boni C, Perica V, Brandt H, Burghardt R, Cassina M, Cesta C, Clementi M, Coleman J, Cone R, Courtet P, Crawford S, Crow S, Crowley J, Danner U, Davis O, de Zwaan M, Dedoussis G, Degortes D, DeSocio J, Dick D, Dikeos D, Dmitrzak-Weglarz M, Docampo E, Egberts K, Ehrlich S, Escaramís G, Esko T, Estivill X, Favaro A, Fernández-Aranda F, Fichter M, Finan C, Fischer K, Föcker M, Foretova L, Forzan M, Franklin C, Gaspar H, Gonidakis F, Gorwood P, Gratacos M, Guillaume S, Guo Y, Hakonarson H, Halmi K, Hatzikotoulas K, Hauser J, Hebebrand J, Helder S, Hendriks J, Herpertz-Dahlmann B, Herzog W, Hilliard C, Hinney A, Huckins L, Hudson J, Huemer J, Imgart H, Inoko H, Jiménez-Murcia S, Johnson C, Jordan J, Juréus A, Kalsi G, Kaminska D, Kaplan A, Kaprio J, Karhunen L, Karwautz A, Kas M, Kaye W, Kennedy J, Kennedy M, Keski-Rahkonen A, Kiezebrink K, Kim Y, Klump K, Knudsen G, Koeleman B, Koubek D, La Via M, Landén M, Levitan R, Li D, Lichtenstein P, Lilenfeld L, Lissowska J, Magistretti P, Maj M, Mannik K, Martin N, McDevitt S, McGuffin P, Merl E, Metspalu A, Meulenbelt I, Micali N, Mitchell J, Mitchell K, Monteleone P, Monteleone A, Mortensen P, Munn-Chernoff M, Nacmias B, Nilsson I, Norring C, Ntalla I, O’Toole J, Pantel J, Papezova H, Parker R, Rabionet R, Raevuori A, Rajewski A, Ramoz N, Rayner N, Reichborn-Kjennerud T, Ricca V, Ripke S, Ritschel F, Roberts M, Rotondo A, Rybakowski F, Santonastaso P, Scherag A, Schmidt U, Schork N, Schosser A, Seitz J, Slachtova L, Slagboom P, Landt M, Slopien A, Smith T, Sorbi S, Strengman E, Strober M, Sullivan P, Szatkiewicz J, Szeszenia-Dabrowska N, Tachmazidou I, Tenconi E, Thornton L, Tortorella A, Tozzi F, Treasure J, Tsitsika A, Tziouvas K, van Elburg A, van Furth E, Wade T, Wagner G, Walton E, Watson H, Woodside D, Yao S, Yilmaz Z, Zeggini E, Zerwas S, Zipfel S, Alfredsson L, Andreassen O, Aschauer H, Barrett J, Bencko V, Carlberg L, Cichon S, Cohen-Woods S, Dina C, Ding B, Espeseth T, Floyd J, Gallinger S, Gambaro G, Giegling I, Herms S, Janout V, Julià A, Klareskog L, Le Hellard S, Leboyer M, Lundervold A, Marsal S, Mattingsdal M, Navratilova M, Ophoff R, Palotie A, Pinto D, Ripatti S, Rujescu D, Scherer S, Scott L, Sladek R, Soranzo N, Southam L, Steen V, Wichmann H, Widen E, Breen G, Bulik C, Thornton L, Magnusson P, Bulik C, Larsson H. Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches. Biological Psychiatry 2019, 86: 577-586. PMID: 31301758, PMCID: PMC6776821, DOI: 10.1016/j.biopsych.2019.04.036.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresAttention-deficit/hyperactivity disorder polygenic risk scoresAttention-deficit/hyperactivity disorderQuantitative genetic modelRisk scoreGenetic associationGenetic correlationsEating disordersRegister-based informationAnorexia nervosaPopulation-based sampleGenetic modelsDegree of relatednessGenetically informed approachesAttention-deficit/hyperactivityNationwide population studyMaternal half-sistersCorrelates of attention-deficit/hyperactivity disorderFull-sistersAttention-deficit/hyperactivity disorder symptomsFamilial coaggregationNationwide populationGenetically informative designsShared etiologySubscales Drive