2024
Genomic insights into the comorbidity between type 2 diabetes and schizophrenia
Arruda A, Khandaker G, Morris A, Smith G, Huckins L, Zeggini E. Genomic insights into the comorbidity between type 2 diabetes and schizophrenia. Schizophrenia 2024, 10: 22. PMID: 38383672, PMCID: PMC10881980, DOI: 10.1038/s41537-024-00445-5.Peer-Reviewed Original ResearchBody mass indexType 2 diabetesType 2 diabetes riskEffect of body mass indexPutative effector genesN-methyl-D-aspartatePublic health challengeIncreased body mass indexLipid-related pathwaysRisk-increasing effectMulti-omics dataMendelian randomizationPotential causal relationshipGene expression studiesDirection of effectMental healthDrug repurposing opportunitiesAssociation signalsGenomic lociGenomic insightsHealth challengesEffector genesGenetic liabilityMass indexExpression studies
2023
Genetically Regulated Gene Expression in the Brain Associated With Chronic Pain: Relationships With Clinical Traits and Potential for Drug Repurposing
Johnston K, Cote A, Hicks E, Johnson J, Huckins L. Genetically Regulated Gene Expression in the Brain Associated With Chronic Pain: Relationships With Clinical Traits and Potential for Drug Repurposing. Biological Psychiatry 2023, 95: 745-761. PMID: 37678542, PMCID: PMC10924073, DOI: 10.1016/j.biopsych.2023.08.023.Peer-Reviewed Original ResearchConceptsGenetically regulated gene expressionMultisite chronic painGene-tissue associationsMean pain scoreUnique genesChronic painAssociation studiesS-PrediXcanGene expressionPain scoresTranscriptome-wide association studyPhenome-wide association studyCardiac dysrhythmiasMetabolic syndromeGenome-wide association studiesAssociated with cardiac dysrhythmiasDrug targetsGenotype-phenotype gapChronic pain developmentAssociation study resultsGene expression changesJoint/ligament sprainsDirection of effectTranscriptome imputationPain traits