2024
Chronic Overlapping Pain Conditions and Nociplastic Pain
Johnston K, Signer R, Huckins L. Chronic Overlapping Pain Conditions and Nociplastic Pain. Human Genetics And Genomics Advances 2024, 100381. PMID: 39497418, DOI: 10.1016/j.xhgg.2024.100381.Peer-Reviewed Original ResearchGenome wide association studiesTranscriptome-wide associationChronic overlapping pain conditionsTissue enrichment analysisSingle nucleotide polymorphismsEnrichment analysisNociplastic painPain conditionsIndependent single nucleotide polymorphismsMultisite chronic painGene set enrichment analysisSNP heritabilityUnique genesNeuropathic pain phenotypesAssociation studiesPolygenic traitChronic pain conditionsGene setsNucleotide polymorphismsMetabolic traitsHeritable traitGenetic overlapPain phenotypesPain descriptorsPain experience
2023
T70. A COMPUTATIONAL TRANSCRIPTOMICS APPROACH TO DRUG REPURPOSING IDENTIFIES NEW THERAPEUTIC CANDIDATES FOR TREATMENT OF CHRONIC PAIN
Cote A, Johnston K, Seah C, Young H, Charney A, Huckins L. T70. A COMPUTATIONAL TRANSCRIPTOMICS APPROACH TO DRUG REPURPOSING IDENTIFIES NEW THERAPEUTIC CANDIDATES FOR TREATMENT OF CHRONIC PAIN. European Neuropsychopharmacology 2023, 75: s199. DOI: 10.1016/j.euroneuro.2023.08.354.Peer-Reviewed Original ResearchResolution of acute painSeverity of chronic painChronic painAcute painExpression signaturesTreatment of chronic pain conditionsAcute low back painPresence of chronic painTreatment of chronic painChronic pain developmentChronic pain phenotypeChronic pain prevalenceChronic pain conditionsLow back painLong-term treatmentTherapeutic candidatePain symptom severityAnti-diabetic medicationsGene expression signaturesPain phenotypesDrug candidatesPain developmentBack painPain prevalencePain conditions
2022
Chronic Pain and Psychiatric Conditions
Johnston K, Huckins L. Chronic Pain and Psychiatric Conditions. Complex Psychiatry 2022, 9: 24-43. PMID: 37034825, PMCID: PMC10080192, DOI: 10.1159/000527041.Peer-Reviewed Original ResearchChronic painLinkage disequilibrium score regression analysisPsychiatric conditionsPain comorbidityDSM-5 psychiatric diagnosisRates of chronic painGenetic overlapPublic health burdenDSM-5Chronic pain conditionsAssociated with increased ratesPotential mechanismsHealth burdenPsychiatric diagnosisPain conditionsTreatment strategiesDepressive disorderPainOverview of relationshipsComorbidityRegression analysisADHDDepressionImpact understandingDisorders