2023
29. GENE EXPRESSION ASSOCIATIONS WITH TRAUMA IN HUMAN POSTMORTEM BRAIN
Hicks E, Seah C, Cote A, Ciarcia J, Chakka A, Group T, Brennand K, Nestler E, Girgenti M, Huckins L. 29. GENE EXPRESSION ASSOCIATIONS WITH TRAUMA IN HUMAN POSTMORTEM BRAIN. European Neuropsychopharmacology 2023, 75: s72. DOI: 10.1016/j.euroneuro.2023.08.139.Peer-Reviewed Original ResearchMajor depressive disorderPost-traumatic stress disorderHuman postmortem brainPostmortem brainsPsychiatric disordersNeurobiological consequencesTranscriptional signatureMajor precipitating factorEarly life stressCase/control statusGene expression associationsType of traumaStress-related disordersTrauma measuresTrauma-exposed individualsTraumatic Stress DisorderExpression associationsBrain donorsDepressive disorderMale miceFrontal cortexPrecipitating factorsMouse modelAnimal modelsPsychosocial stress
2022
Altered gene expression and PTSD symptom dimensions in World Trade Center responders
Marchese S, Cancelmo L, Diab O, Cahn L, Aaronson C, Daskalakis NP, Schaffer J, Horn SR, Johnson JS, Schechter C, Desarnaud F, Bierer LM, Makotkine I, Flory JD, Crane M, Moline JM, Udasin IG, Harrison DJ, Roussos P, Charney DS, Koenen KC, Southwick SM, Yehuda R, Pietrzak RH, Huckins LM, Feder A. Altered gene expression and PTSD symptom dimensions in World Trade Center responders. Molecular Psychiatry 2022, 27: 2225-2246. PMID: 35177824, DOI: 10.1038/s41380-022-01457-2.Peer-Reviewed Original ResearchConceptsPTSD symptom dimensionsPosttraumatic stress disorderCAPS scoresAnxious arousal symptomsSymptom dimensionsWorld Trade Center rescueClinician-Administered PTSD Scale scoresBiomarker of PTSDArousal symptomsCD4 T cellsWorld Trade Center respondersDevelopment of PTSDTotal CAPS scoresCase/control statusTherapeutic target developmentIdentification of biomarkersClinical interview dataResponder cohortPTSD symptom severityPotential biological differencesWTC respondersT cellsGene expressionPTSD studiesPsychiatric disorders